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Research unit director
* These authors contributed equally to this work.
$ Both these authors act as corresponding authors


Robert F. (2018) Bidirectional terminators: an underestimated aspect of gene regulation. Curr Genet. 2018 Apr;64(2):389-391. doi: 10.1007/s00294-017-0763-y.


Robert F. (2017) Spt6 Gets in the Way of Polycomb to Promote ESC Pluripotency. Mol Cell. 2017 Oct 19;68(2):263-264. doi: 10.1016/j.molcel.2017.10.005.

Jeronimo C, Robert F. (2017) The Mediator Complex: At the Nexus of RNA Polymerase II Transcription. Trends Cell Biol. 2017 Aug 1. pii: S0962-8924(17)30116-2. doi: 10.1016/j.tcb.2017.07.001.

Uwimana N, Collin P, Jeronimo C, Haibe-Kains B, Robert F. (2017) Bidirectional terminators in Saccharomyces cerevisiae prevent cryptic transcription from invading neighboring genes. Nucleic Acids Res. 2017 Apr 5. doi: 10.1093/nar/gkx242.

Reddy BA, Jeronimo C, Robert F. (2017) Recent Perspectives on the Roles of Histone Chaperones in Transcription Regulation. Current Molecular Biology Reports. 2017;3(1):1–10.

Jeronimo C, Robert F. (2017) A Spiking Strategy for ChIP-chip Data Normalization in S. cerevisiae. Methods Mol Biol. 2017;1528:211-227.


Jeronimo C, Langelier M-F, Bataille AR, Pascal JM, Pugh BF, Robert F. (2016) Tail and Kinase modules differently regulate core Mediator recruitment and function in vivo. Mol. Cell. 2016 Oct 18. pii: S1097-2765(16)30519-6. doi: 10.1016/j.molcel.2016.09.002.

Steunou AL, Cramet M, Rossetto D, Aristizabal MJ, Lacoste N, Drouin S, Côté V, Paquet E, Utley RT, Krogan N, Robert F, Kobor MS, Côté J. (2016) Combined action of histone reader modules regulates NuA4 local acetyltransferase function but not its recruitment on the genome. Mol Cell Biol. 2016 Oct 28;36(22):2768-2781

Fraszczak J, Helness A, Chen R, Vadnais C, Robert F, Khandanpour C, Möröy T. (2016) Threshold Levels of Gfi1 Maintain E2A Activity for B Cell Commitment via Repression of Id1. PLoS One. 2016 Jul 28;11(7):e0160344. doi: 10.1371/journal.pone.0160344. eCollection 2016.

Gaudreau MC, Grapton D, Helness A, Vadnais C, Fraszczak J, Shooshtarizadeh P, Wilhelm B, Robert F, Heyd F, Möröy T. (2016) Heterogeneous Nuclear Ribonucleoprotein L is required for the survival and functional integrity of murine hematopoietic stem cells. Sci Rep. 2016 Jun 7;6:27379. doi: 10.1038/srep27379.

Botezatu L, Michel LC, Helness A, Vadnais C, Makishima H, Hönes JM, Robert F, Vassen L, Thivakaran A, Al-Matary Y, Lams RF, Schütte J, Giebel B, Görgens A, Heuser M, Medyouf H, Maciejewski J, Dührsen U, Möröy T, Khandanpour C. (2016) Epigenetic therapy as a novel approach for GFI136N-associated murine/human AML. Exp Hematol. 2016 Aug;44(8):713-726.e14. doi: 10.1016/j.exphem.2016.05.004. Epub 2016 May 20.

Jeronimo, C. and Robert, F. (2016) Histone chaperones FACT and Spt6 prevent histone variants from turning into histone deviants. Bioessays. 2016 Mar 15. doi: 10.1002/bies.201500122. [Epub ahead of print]

Jeronimo, C., Collin, P., Robert, F. (2016) The RNA Polymerase II CTD : The Increasing Complexity of a Low-Complexity Protein Domain. J Mol Biol.  2016 Feb 12. pii: S0022-2836(16)00111-X. doi: 10.1016/j.jmb.2016.02.006. [Epub ahead of print]

Hönes, J.M., Botezatu, L., Helness, A., Vadnais, C., Vassen, L., Robert, F., Hergenhan, S.M., Thivakaran, A., Schütte, J., Fraszscak, J., Makishima, H., Radivoyevitch, T., Przychodzen, B., Vitoriano da Conceição Castro, S., Görgens, A., Giebel, B., Klein-Hitpass, L. Lennartz, K., Heuser, M., Thiede, C., Ehninger, G., Dührsen, U. Maciejewski, J., Möröy, T. and Khandanpour, C. (2016) GFI1 as a novel prognostic and therapeutic factorLeukemia. 2016  Feb 5. doi: 10.1038/leu.2016.11. [Epub ahead of print]


Jeronimo, C., Watanabe, S., Kaplan, C.D., Peterson, C.L., Robert, F. (2015) The Histone Chaperones FACT and Spt6 Restrict H2A.Z from Intragenic Locations. Mol. Cell 2015 Jun 18;58(6):1113-23. doi: 10.1016/j.molcel.2015.03.030. Epub 2015 May 7.

Cheng, X., Auger, A., Altaf, M., Drouin, S., Paquet, E., Utley, R.T., Robert, F., Côté, J. (2015) Eaf1 Links the NuA4 Histone Acetyltransferase Complex to Htz1 Incorporation and Regulation of Purine Biosynthesis. Eukaryot Cell. 2015 Jun;14(6):535-44. doi: 10.1128/EC.00004-15. Epub 2015 Apr 3.


Burugula, B.B., Jeronimo, C., Pathak, R., Jones, J.W., Robert, F., Govind, C.K. (2014) Histone deacetylases and Phosphorylated Pol II CTD recruit Spt6 for cotranscriptional histone reassembly. Mol Cell Biol. 2014 Nov 15;34(22):4115-29. doi: 10.1128/MCB.00695-14. Epub 2014 Sep 2.

Gasmi, N., Jacques, P.E., Klimova, N., Guo, X., Ricciardi, A., Robert, F., Turcotte, B. (2014) The Switch from Fermentation to Respiration in Saccharomyces cerevisiae Is Regulated by the Ert1 Transcriptional Activator/RepressorGenetics. 2014 Oct;198(2):547-60. doi: 10.1534/genetics.114.168609. Epub 2014 Aug 13.

Shahbabian, K., Jeronimo, C., Forget, A., Robert F. and Chartrand, P. (2014) Co-transcriptional recruitment of Puf6 by She2 couples translational repression to mRNA localization. Nucleic Acids Res. Jul 10. (Epub ahead of Print)

Coulombe, C., Poitras, C., Nordell-Markovits, A., Brunelle, M., Lavoie, M.A., Robert, F$. and Jacques, P.E.$ (2014) VAP : a versatile aggregate profiler for efficient genome-wide data representation and discovery. Nucleic Acids Res. 42 (Web Server issue):W485-93.

Jeronimo, C. and Robert, F (2014) Kin28 regulates the transient association of Mediator with core promoters. Nat Struct Mol Biol., 21 (5):449-55.


Praktiknjo, S.D., Llamas, B., Scott-Boyer, M.P., Picard, S., Robert, F., Langlais, D., Haibe-Kains, B., Faubert, D., Silversides, D.W. and Deschepper, C.F. (2013) Novel effects of chromosome Y on cardiac regulation, chromatin remodeling, and neonatal programming in male mice. Endocrinology, 154(12):4746-56.

Jeronimo, C., Bataille, A.R. and Robert, F (2013) The Writers, Readers, and Functions of the RNA Polymerase II C-Terminal Domain Code. Chem. Rev., 113(11):8491-522.

Woo, S., Zhang, X., Sauteraud, R., Robert, F. and Gottardo R. (2013) PING 2.0: An R/Bioconductor package for nucleosome positioning using next-generation sequencing data. Bioinformatics, 29(16):2049-50.


Sansó, M., Lee, K.M., Viladevall, L., Jacques, P.É., Pagé, V., Nagy, S., Racine, A., St Amour, C.V., Zhang, C., Shokat, K.M., Schwer, B., Robert, F., Fisher, R.P., Tanny, J.C. (2012) A Positive Feedback Loop Links Opposing Functions of P-TEFb/Cdk9 and Histone H2B Ubiquitylation to Regulate Transcript Elongation in Fission Yeast. PLoS Genet., 8(8):e1002822.

Soontorngun, N., Baramee, S., Tangsombatvichit, C., Thepnok, P., Cheevadhanarak, S., Robert, F., Turcotte, B. (2012) Genome-wide location analysis reveals an important overlap between the targets of the yeast transcriptional regulators Rds2 and Adr1. Biochem. Biophys. Res. Commun. 423(4):632-7.

Bataille, A.R.*, Jeronimo, C.*, Jacques, P.E., Laramée, L., Fortin, M.-E., Forest, A., Bergeron, M., Hanes, S.D. and Robert, F. (2012) A Universal RNA Polymerase II CTD Cycle Is Orchestrated by Complex Interplays between Kinase, Phosphatase, and Isomerase Enzymes along Genes. Mol. Cell, 45:158-170.


Poschmann, J., Drouin, S., Jacques, P.E., El Fadili, K., Newmarch, M., Robert, F., Ramotar, D. (2011) The Peptidyl Prolyl Isomerase Rrd1 Regulates the Elongation of RNA Polymerase II during Transcriptional Stresses. PLoS One, 6(8):e23159.

Gonsalves, S.E., Moses, A.M., Razak, Z., Robert, F., Westwood, J.T. (2011) Whole-Genome analysis reveals that active heat shock factor binding sites are mostly associated with non-heat shock genes in Drosophila melanogaster. PLoS One, 6(1):e15934.

Ivanovska, I., Jacques, P.É., Rando, O.J., Robert, F., Winston, F. (2011) Control of chromatin structure by spt6: different consequences in coding and regulatory regions. Mol Cell Biol, 31(3):531-541.


Drouin, S., Laramée, L.*, Jacques, P.E.*, Forest, A., Bergeron, M., Robert, F. (2010) DSIF and RNA polymerase II CTD phosphorylation coordinate the recruitment of Rpd3S to actively transcribed genes. PLoS Genet, 6(10):e1001173, 1-12.

Hardy, S., Robert, F. (2010) Random deposition of histone variants: A cellular mistake or a novel regulatory mechanism? Epigenetics. 5(5).


Szilard, R.K.*, Jacques, P.E.*, Laramée, L., Cheng, B., Galicia, S., Bataille, A.R., Yeung, M., Mendez, M., Bergeron, M., Robert, F$. and Durocher, D$. (2009) Systematic identification of fragile sites via genome-wide location analysis of gamma-H2AX. Nat Struct Mol Biol. 17(3):299-305.

Hardy, S.*, Jacques, P.-E.*, Gévry, N., Forest, A., Fortin, M.-È., Laflamme, L., Gaudreau, L. and Robert, F. (2009) The Euchromatic and Heterochromatic Landscapes Are Shaped by Antagonizing Effects of Transcription on H2A.Z Deposition. PLoS Genetics 5(10), e1000687.

Ghazal, G., Gagnon, J., Jacques, P.-E., Landry, J.-R., Robert, F. and Abou Elela, S. (2009) Yeast RNase III Triggers Polyadenylation-Independent Transcription Termination. Mol. Cell 36, 99-109.

Turcotte, B., Liang, X.B., Robert, F. and Soontorngun, N. (2009) Transcriptional regulation of nonfermentable carbon utilization in budding yeast. FEMS Yeast Res. Epub ahead of print.

Gévry, N., Hardy, S., Jacques, P.E., Laflamme, L., Svotelis, A., Robert, F., Gaudreau, L. (2009) Histone H2A.Z is essential for estrogen receptor signaling. Genes Dev 23:1522-1533.

Bataille, A.R. and Robert, F. (2009) Profiling genome-wide histone modifications and variants by ChIP-chip on tiling microarrays in S. cerevisiae. Methods Mol Biol 543, 267-279.


Znaidi, S., Weber, S., Al-Abdin, O.Z., Bomme, P., Saidane, S., Drouin, S., Lemieux, S., De Deken, X., Robert, F. and Raymond, M. (2008) Genomewide Location Analysis of Candida albicans Upc2p, a Regulator of Sterol Metabolism and Azole Drug Resistance. Eukaryot Cell 7(5), 836-47.

Truscott, M., Harada, R., Vadnais, C., Robert, F. and Nepveu, A. (2008) p110 CUX1 Cooperates with E2F Transcription Factors in the Transcriptional Activation of Cell Cycle-Regulated Genes. Mol. Cell. Biol. 28(10), 3127-38.


Harada, R., Vadnais, C., Sansregret, L., Leduy, L., Bérubé, G., Robert, F. and Nepveu, A. (2007) Genome-Wide Location Analysis and Expression Studies Reveal a Role for p110 CUX1 in the Activation of DNA Replication Genes. Nucleic Acids Res. 36(1), 189-202.

Soontorngun, N., Larochelle, M., Drouin, S., Robert, F. and Turcotte, B. (2007) Regulation of gluconeogenesis in Saccharomyces cerevisiae is mediated by activator and repressor functions of Rds2. Mol. Cell. Biol. 27(22), 7895-7905.

Rufiange, A.*, Jacques, P-E.*, Bhat, W., Robert, F. and Nourani, A. (2007) Genome-Wide Replication-Independent Histone H3 Exchange Occurs Predominantly at Promoters and Implicates H3 K56 Acetylation and Asf1. Mol. Cell 27, 393-405.

Sonoda, J., Laganière, J., Mehl, I.R., Barish, G.D., Chong, L-W., Li, X., Scheffler, I.E., Mock, D.C., Bataille, A.R., Robert, F., Lee, C-H., Giguère, V., Evans, R.M. (2007) Nuclear receptor ERalpha and coactivator PGC1-beta are effectors of IFN-gamma-induced host defence. Genes Dev. 21, 1909-1920

Ferretti, V.*, Poitras, C*., Bergeron, D., Coulombe, B., Robert, F. and Blanchette, M. (2007) PReMod: A Database of genome-wide mammalian cis-regulatory module predictions. Nucleic Acids Res. 35(Database issue):D122-6.


Larochelle, M.*, Drouin, S*., Robert, F. and Turcotte, B. (2006) Oxidative Stress-Activated Zinc Cluster Protein Stb5 Has Dual Activator/Repressor Functions Required for Pentose Phosphate Pathway Regulation and NADPH Production. Mol. Cell. Biol. 26(17), 6690-6701.     

Blanchette, M.$, Bataille, A.R., Chen, X., Poitras, C., Laganière, J., Lefèbvre, C., Deblois, G., Giguère, V., Ferretti, V., Bergeron, D., Coulombe, B. and Robert, F$. (2006) Genome-wide Computational Prediction of Transcriptional Regulatory Modules Reveals New Insights into Human Gene Expression. Genome Research 16, 656-668. PReMod (Accompanying database)

Nourani, A., Robert, F. and Winston, F. (2006) Evidence that Spt2/Sin1, an HMG-like Factor, Plays Roles in Transcription Elongation, Chromatin Structure, and Genome Stability in Saccharomyces cerevisiae. Mol. Cell. Biol. 26(4), 1496-1509.


Guillemette, B.*, Bataille, A.*, Gévry, N., Adam, M., Blanchette, Robert, F$. and Gaudreau, L$. (2005) Variant Histone H2A.Z is Globally Localized to the Promoters of Inactive Yeast Genes and Regulates Nucleosome Positioning. PLoS Biology 3(12), e384.

Laganière, J., Deblois, G., Lefebvre, C., Bataille, A.R., Robert, F. and Giguère, V. (2005) Location Analysis of Estrogen Receptor alpha Target Promoters Reveals that FOXA1 Defines a Domain of the Estrogen Response. Proc. Natl. Acad. Sci. USA 102, 11651-11656.

prior to 2005

Robert, F.*, Pokholok, D.K.*, Hannett, N.M., Rinaldi, N.J., Chandy, M., Rolfe, A., Workman, J.L., Gifford, D.K., Young, R.A. (2004) Global Position and Recruitment of HATs and HDACs in the Yeast Genome. Mol Cell 16, 199-209.

Bar-Joseph, Z., Gerber, G.K., Rinaldi, N.J., Lee, T.I., Harbison, C.T., Robert, F., Gordon, D.B., Fraenkel, E., Simon, I., Jaakkola, T.S., Young, R.A. and Gifford, D.K. (2003) Computational discovery of gene modules and regulatory networks. Nature Biotechnology 21, 1337-1342.

Ng, H.H.*, Robert, F.*, Young, R., A. and Struhl, K (2003) Localized marking of active Pol II genes targeted recruitment of Set1 histone methylase provides a memory of recent transcriptional activity. Mol Cell 11, 709-19.

Lee, T. I.*, Rinaldi, N.J.*, Robert, F.*, Odom, D.T., Bar-Joseph, Z., Gerber, G.K., Hannett, N.M., Harbison, C.T., Thompson, C.M., Simon, I., Zeitlinger, J., Jennings, E.G., Murray, H.L., Gordon, D.B., Ren, B., Wyrick, J.J., Tagne, J-B, Volkert, T.L., Fraenkel, E., Gifford, D.K., Young, R.A. (2002) Transcriptional Regulatory Networks in Saccharomyces cerevisiae. Science 298, 799-804.

Ng, H.H.*, Robert, F.*, Young, R., A. and Struhl, K (2002) Genome-wide Location and Regulated Recruitment of the RSC nucleosome-remodeling complex. Genes Dev. 16, 806-819.

Robert, F., Blanchette, M., Maes, O., Chabot, B. and Coulombe, B. (2002) A human RNA polymerase II-containing complex associated with factors necessary for spliceosome assembly. J. Biol. Chem. 277, 9302-9306.

Adam, M.*, Robert, F.*, Larochelle, M.* and Gaudreau, L. (2001) H2A.Z is Required for Global Chromatin Integrity and for Recruitment of RNA Polymerase II under Specific Conditions. Mol. Cell. Biol. 21, 6270-6279.

Ren, B.*, Robert, F.*, Wyrick, J. J.*, Aparicio, O., Jennings, E. G., Simon, I., Zeitlinger, J., Schreiber, J., Hannett, N., Kanin, E., Volkert, T. L., Wilson, C. J., Bell, S. P. and Young, R. A. (2000) Genome-wide Location and Function of DNA Binding Proteins. Science, 290, 2306-2309.

Robert, F. and Coulombe, B. Methods in Molecular Biology 2nd edition: The use of site-specific protein-DNA photo-crosslinking to analyse the molecular organization of the RNA polymerase II initiation complex (Hunana Press, Totowa, NJ, USA).

Robert, F., Douziech, M., Forget, D., Elgy, J-M., Greenblatt, J., Burton, Z. F. and Coulombe, B. (1998) Wrapping of Promoter DNA around the RNA Polymerase II Initiation Complex Induced by TFIIF. Mol. Cell 2, 341-351.

Forget, D., Robert, F., Grondin, G., Burton, Z. F., Greenblatt, J. and Coulombe, B. (1997) RAP74 Induces Promoter Contacts by RNA Polymerase II Upstream and Downstream of a DNA Bend Centered on the TATA box. Proc. Natl. Acad. Sci. USA 94, 7150-7155.

Robert, F., Forget, D., Li, J., Greenblatt, J. and Coulombe, B. (1996) Localization of Subunits of Transcription Factors IIE and IIF Immediately Upstream of the Transcription Initiation Site of the Adenovirus Major Late Promoter. J. Biol. Chem. 271(5), 8517-8520.

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