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Selected Publications

Schiller PW, Fundytus ME, Merovitz, Weltrowska G, Nguyen TM-D, Lemieux C, Chung, NN, Coderre TJ. The Opioid μ Agonist/δ Antagonist DIPP-NH2[Ψ] Produces a Potent Analgesic Effect, no Physical Dependence and less Tolerance than Morphine in Rats. J Med Chem 1999;42:3520-3526.
Schiller PW, Nguyen TM-D, Berezowska I, Dupuis S, Weltrowska G, Chung NN, Lemieux C. Synthesis and In Vitro Opioid Activity Profiles of DALDA Analogues. Eur J Med Chem 2000;35:895-901.
Lu Y, Nguyen TM-D, Weltrowska G, Berezowska I, Lemieux C, Chung NN, Schiller PW. [2',6'-Dimethyltyrosine1]Dynorphin A(1-11)-NH2 Analogues Lacking an N-Terminal Amino Group: Potent and Selective κ Opioid Antagonists. J Med Chem 2001;44:3048-3053.
Schiller PW, Weltrowska G, Nguyen TM-D, Lemieux C, Chung NN, Lu Y. Conversion of δ-, κ- and μ-Receptor Selective Opioid Peptide Agonists Into δ-, κ- and μ-Selective Antagonists. Life Sci 2003;73:691-698.
Zhao K, Zhao G-M, Wu D, Soong Y, Birk AV, Schiller PW, Szeto HH. Cell-Permeable Antioxidant Peptides Targeted to Inner Mitochondrial Membrane Inhibit Mitochondrial Swelling, Oxidative Cell Death and Reperfusion Injury. J Biol Chem 2004:279:34682-34690.
Audet N, Galés C, Archer-Lahlou É, Valliers M, Schiller PW, Bouvier M, Piñeyro G. Bioluminescence Resonance Energy Transfer Assays Reveal Ligand-specific Conformational Changes within Preformed Signaling Complexes Containing δ-Opioid Receptors and Heterotrimeric G Proteins. J Biol Chem 2008;283:15078-15088.
Ghosh A, Luo J, Weltrowska G, Lemieux C, Chung NN, Lu Y, Schiller PW. Novel Opioid Peptide Derived Antagonists Containing (2S)-2-Methyl-3-(2,6-dimethyl-4-carbamoylphenyl)propanoic Acid [(2S)-Mdpc]. J Med Chem 2008;51:5866-5870.
Schiller PW. Bi- or Multifunctional Opioid Peptide Drugs. Life Sci 2010:6:598-603.
Weltrowska G, Chung NN, Lemieux C, Guo J, Lu Y, Wilkes BC, Schiller PW. “Carba”-Analogues of Fentanyl are Opioid Receptor Agonists. J Med Chem 2010:53:2875-2881.

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