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Research unit director

Selected publications:

Follmer, N.E., Wani, A.H. and Francis, N.J. (2012) Polycomb Group proteins are retained at specific sites on chromatin in mitosis. PLoS Genet 8(12): e1003135. doi:10.1371/journal.pgen.1003135.

Lo, S.M., McElroy, K.A. and Francis, N.J. (2012) Chromatin modification by PSC occurs at one PSC per nucleosome and does not require the acidic patch of histone H2A. PLoS ONE 7(10): e47162. doi:10.1371/journal.pone.0047162. PMID: 23071745

Lengsfeld, B.M., Berry, K.N., Ghosh, S., Takahashi, M., and Francis, N.J. (2012) A Polycomb complex remains bound through DNA replication in the absence of other eukaryotic proteins. Sci. Rep. 2: 661. PMID:22993687.

Lo, S.M.*, Follmer, N.E.*, Lengsfeld, B.M., Madamba, E.V., Seong, S., Grau, D.J., and Francis, N.J. (2012) A Bridging model for persistence of a Polycomb Group protein complex through DNA replication. Mol. Cell 46: 784-796. PMID: 22749399.

Beh, L.Y., Colwell, L.J., and Francis, N.J. (2012) A core subunit of Polycomb repressive complex 1 is broadly conserved in function but not primary sequence. PNAS, 109(18):E1063-71. PMID:22517748

Grau, D.J., Chapman, B.A., Garlick, J.D., Borowsky, M., Francis, N.J., Kingston, R.E. (2011) Compaction of chromatin by diverse Polycomb group proteins requires localized regions of high charge.  Genes Dev., 25:2210-21. PMID: 22012622

Lo, S.M. and Francis, N.J. (2010) Inhibition of Chromatin Remodeling by Polycomb Group Protein Posterior Sex Combs Is Mechanistically Distinct from Nucleosome Binding.  Biochemistry 49:9438-9448.  PMID:  20873869.

Francis, N.J., Follmer, N.E., Simon, M.D., Aghia, G., and Butler, J.D. (2009) Polycomb proteins remain bound to chromatin and DNA during replication in vitro.  Cell, 137: 110-122.  PMID: 19303136.

Lo, S.M., Ahuja, N.K., Francis, N.J.  (2009) Polycomb group protein Suppressor 2 of zeste is a functional homolog of Posterior Sex Combs.  Mol. Cell. Biol. 29: 515-525. PMID: 18981224.

King, I.F.G.*, Emmons, R.B.*, Francis, N.J.*, Wild, B., Mueller, J., Kingston, R.E., Wu, C.-t. (2005)  Analysis of a Polycomb Group protein defines regions that link repressive activity on nucleosomal templates to in vivo function.  Mol. Cell. Biol. 25: 6578-6591.

Francis, N.J., Kingston, R.E., and Woodcock, C.L. (2004) Chromatin compaction by a Polycomb group protein complex. Science 306:1574-1577.

Lavigne, M., Francis, N.J., King, I.F., and Kingston, R.E. (2004) Propagation of silencing; recruitment and repression of naïve chromatin in trans by polycomb repressed chromatin. Mol. Cell 13: 415-425.

Muller, J.*, Hart, C.M.*, Francis, N.J.*, Vargas, M.L., Sengupta, A., Wild,B., Miller, E.L., O'Connor, M.B., Kingston, R.E., and Simon, J.A.   (2002)  Histone methyltransferase activity of a Drosophila Polycomb Group repressor complex.  Cell, 111:197-208.

Francis. N.J., Saurin, A.J., Shao, Z. and Kingston, R.E. (2001) Reconstitution of a functional core Polycomb repressive complex.  Mol. Cell, 8: 545-556.

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