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The IRCM > Research > Research divisions > Cancer et maladies génétiques > Génétique moléculaire et développement
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Research unit director
Molecular Genetics and Development

One of the main objectives of this research unit is to study molecular mechanisms that control genetic regulation and expression in transgenic mice. Scientists on this team have produced a sickle cell transgenic mouse model through a mutation in the adult beta-globin gene to study the pathophysiology of the disease and to develop effective gene therapy approaches. They are also analyzing transcriptional factors involved in the most primitive cells of hematopoietic differentiation. Furthermore, they are characterizing the PKD1 gene responsible for polycystic kidney disease and studying the signal transduction pathway using a transgenic mouse model induced with the protooncogène c-myc.

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