Dr. Möröy’s objective in his research on hematopoiesis and cancer is to advance our understanding of the molecular basis of physiology, ontogenesis, and the differentiation of blood cells, and to reveal the mechanisms leading to cancer in the hematopoietic system, i.e. leukemia and lymphoma. His research program focuses on the role transcription factors and chromatin regulators play, such as the zinc-finger proteins Gfi1 and Gfi1b and transcription factor POZ/BTB Miz-1. The general approach Dr. Möröy uses to understand the way they function is to generate mutant alleles by targeting genes in the mouse. This extremely powerful technique has given Dr. Möröy’s team deeper insight into critical steps in hematopoietic differentiation, specifically stem cell self-renewal.