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Research unit director

Selected publications

Hönes JM, Botezatu L, Helness A, Vadnais C, Vassen L, Robert F, Hergenhan SM, Thivakaran A, Schütte J, Al-Matary YS, Lams RF, Fraszczak J, Makishima H, Radivoyevitch T, Przychodzen B, Vitoriano da Conceição Castro S, Görgens A, Giebel B, Klein-Hitpass L, Lennartz K, Heuser M, Thiede C, Ehninger G, Dührsen U, Maciejewsi J, Möröy T*, Khandanpour C* (*co-senior authors).
GFI1 as a novel prognostic and therapeutic factor for AML/MDS.
Leukemia, 2016,  Feb 5. doi: 10.1038/leu.2016.11. 

Rashkovan M, Vadnais C, Ross J, Gigoux M, Suh WK, Gu W and Möröy T.
Miz-1 regulates translation of Trp53 via ribosomal protein L22 in cells undergoing V(D)J recombination.
Proc. Natl. Acad. Sci. USA, 2014, Dec 16;111(50):E5411-9

Preußner M, Wilhelmi I, Schultz AS, Finkernagel F, Michel M, Möröy T, Heyd F.
Rhythmic U2af26 alternative splicing controls PERIOD1 stability and the circadian clock in mice.
Molecular Cell, 2014 May 22;54(4):651-62.

Khandanpour C, Phelan JD, Vassen L, Schütte J, Chen R, Horman S, Gaudreau MC, Krongold J, Zhu J, Paul WE, Dührsen U, Göttgens B, Grimes HL and Möröy T.
Growth factor independence 1
(Gfi1) antagonizes a p53-induced DNA damage response pathway in lymphoblastic leukemia.
Cancer Cell, 2013, Feb 11;23(2):200-14.

Khandanpour C, Krongold J, Schütte J, Bouwman F, Vassen L, Chen R, Gaudreau MC, Van der Reijden B, Hannah R, Diamanti E, Nieto FC, Meyer S, Grimes HL, Jansen J, Lowenberg B, Peeters JK, Patel C, Duehrsen U, Göttgens B, and Möröy T.
The human GFI136N variant induces epigenetic changes at the Hoxa9 locus and accelerates K-RAS driven myeloproliferative disorder in mice.
Blood, 2012, Nov 8;120(19):4006-17.

Schulz D, Vassen L, Amin R, Möröy T and Schlissel M.
Gfi1b negatively regulates Rag expression directly and via the repression of FoxO1.
J. Exp. Medicine, 2012, Jan 16;209(1):187-99

Saba, I, Kosan C and Möröy T.
IL-7R-dependent survival and differentiation of early T-lineage progenitors is regulated by the BTB/POZ domain transcription factor Miz-1.
Blood, 2011 Mar 24;117(12):3370-81.

Khandanpour C, Kosan C, Gaudreau MC, Dührsen U, Zeng H and Möröy T.
Growth factor independence 1 (Gfi1) protects hematopoietic stem cells against apoptosis but also prevents the development of a myeloproliferative-like disease.
Stem Cells, 2011 Feb 24;29:376–385.

Kosan C, Saba I, Godmann M, Herold S, Herkert B, Eilers M and Möröy T.
The BTB/POZ domain protein Miz-1 (Zbtb17) is required to regulate IL-7 receptor signaling at early commitment stages of B cell differentiation.
Immunity, 2010, Dec 14;33(6):917-28.

Khandanpour C, Sharif-Askari E, Gaudreau MC, Vassen L, Zhu J, Paul W, Okoyama T, Kosan C, and Möröy T.
Evidence that Growth factor independence 1b (Gfi1b) regulates dormancy and peripheral blood mobilization of hematopoietic stem cells
Blood, 2010, Dec, Vol. 116, No. 24, pp. 5149-5161. (Faculty 1000 Rating 6)

Sharif-Askari E, Vassen L, Kosan C, Khandanpour C, Gaudreau MC, Heyd F, Okayama T, Jin J, Rojas MEB, Grimes HL, Zeng H and Möröy T.
Zinc finger protein Gfi1 controls the endotoxin-mediated TLR inflammatory response by antagonizing NF-kB p65.
Mol. Cell. Biol., 2010, Aug;30(16):3929-42.

Van Riggelen J, Müller J, Otto T, Beuger V, Yetil A, Choi P, Kosan C, Möröy T, Felsher D, and Eilers M.
The interaction between Myc and Miz1 is required to antagonize TGF beta-dependent autocrine signaling during lymphoma formation and maintenance
Genes & Development, 2010 Jun 15;24(12):1281-94.

Khandanpour C,Thiede C, Valk, PJM, Sharif-Askari E, Nückel H, Lohmann D, Horsthemke B, Siffert W, Neubauer A, Grzeschik KH, Bloomfield CD, Marcucci G, Maharry K, Slovak ML, van der Reijden BA, Jansen JA, Schackert HK, Afshar K, Schnittger S, Peeters JK, Kroschinsky F, Ehninger G, Lowenberg B, Dührsen D and Möröy T
A variant allele of Growth Factor Independence 1 (GFI1) is associated with acute myeloid leukemia
Blood, 2010, Mar 25;115(12):2462-72.

Vassen L, Khandanpour C, Ebeling P, van der Reijden BA, Jansen JH, Mahlmann S, Dührsen U and Möröy T
Growth factor independent 1b (Gfi1b) and a new splice variant of Gfi1b are highly expressed in patients with acute and chronic leukemia.
Int. J. Hematol., 2009, May;89(4):422-30.

Igwe E, Kosan C, Khandanpour C, Sharif-Askari E, Brüne B and Möröy T
The zinc finger protein Gfi1 is implicated in the regulation of IgG production and the expression of Ig2b germ line transcripts.
Eur. J. Immunol., 2008, Nov;38(11):3004-14.

Pargmann D, Yücel R, Kosan C, Klein-Hitpass L, Schimmer S, Dittmer U and Möröy T
Differential impact of the transcriptional repressor Gfi1 on mature CD4+ and CD8+ T-lymphocyte function.
Eur. J. Immunol., 2007, 37(12):3551-63.

Vassen L, Okayama T and Möröy T
Gfi1b:Green fluorescent protein knock-in mice reveal a dynamic expression pattern of Gfi1b during hematopoiesis that is largely complementary to Gfi1.
Blood, 2007, 2007 Mar 15;109(6):2356-64.

Heyd F, Ten Dam G, Möröy T
Auxiliary splice factor U2AF26 and transcription factor Gfi1 cooperate directly in regulating CD45 alternative splicing.
Nature Immunology, 2006 Aug;7(8):859-67.

Vassen L, Fiolka K, Möröy T
Gfi1b alters histone methylation at target gene promoters and sites of gamma-satellite containing heterochromatin.
EMBO J., 2006 Jun 7;25(11):2409-19.

Fiolka K, Hertzano R, Vassen L, Zeng H, Hermesh O, Avraham KB Dührsen U and Möröy T
Gfi1 and Gfi1b act equivalently in hematopoiesis but have distinct, non-overlapping functions in inner ear development.
EMBO Reports, 2006, Mar; 7, (3), 326–333.

Rathinam C, Geffers R, Yücel R, Buer J, Welte K, Möröy T and Klein C
The transcriptional repressor Gfi1 controls STAT3-dependent dendritic cell development and –function
Immunity, 2005, Jun;22(6):717-28.

Zeng H, Yücel R, Kosan C, Klein-Hitpass L and Möröy T
Transcription factor Gfi1 regulates self-renewal and long-term engraftment abilities of hematopoietic stem cells by restricting their proliferative potential
EMBO J., 2004, 23(20):4116-4125.

Yücel R, Kosan C, Heyd F and Möröy T
Gfi1:Gfp knock-in mutant reveals differential expression and auto-regulation of the gene growth factor independence 1 (Gfi1) during lymphocyte development.
J. Biol. Chem., 2004, 279(39):40906-40917

Yücel, R, Karsunky H, Klein-Hitpass L and Möröy T
The transcriptional repressor Gfi1 affects development of early, uncommitted c-Kit+ T-cell progenitors and CD4/CD8 lineage decision in the thymus.
J. Exp. Med, 2003 Apr 7;197(7):831-44.

Karsunky H, Zeng H, Schmidt T, Zevnik B, Kluge R, Schmid KW, Dührsen U and Möröy T
Inflammatory Reactions and Severe Neutropenia in Mice Lacking the Transcriptional Repressor Gfi-1.
Nature Genetics, 2002, Vol 30 No.3, 295-300

Geisen C and Möröy T
The oncogenic activity of cyclin E is not confined to Cdk2 activation alone but relies on several other, distinct functions of the protein.
J Biol Chem. 2002 Oct 18, 277 (42): 39909-39918.

Beneke R and Möröy T
Inhibition of poly(ADP-ribose)polymerase activity accelerates T-cell lymphomagenesis in p53 deficient mice
Oncogene. 2001 Dec 6; 20(56): 8136-8141

Staller P, Peukert K, Seoane J, Lukas J, Karsunky H, Möröy T, Bartek J, Massague J, Hänel F, Eilers M.
Repression of p15ink4b expression by Myc via association with Miz-1
Nature Cell Biology. 2001, Apr;3(4):392-399.
finger protein
Napirei M, Karsunky H, Zevnik B, Stephan H, Mannherz HG, Möröy T
Features of systemic lupus erythematosus in Dnase1-deficient mice.
Nature Genetics 2000 Jun;25(2):177-81.

Beneke R, Geisen C, Zevnik B, Küpper JH, Möröy T
DNA excision repair and DNA damage-induced apoptosis are linked to poly(ADP-ribosyl)ation but have different requirements for p53.
Mol. Cell. Biol. 2000 Sep. 20 (18): 6695-6703

Karsunky H, Geisen C, Schmidt T, Haas K, Zevnik B, Gau E, Möröy T
Oncogenic potential of cyclin E in T-cell lymphomagenesis in transgenic mice: evidence for cooperation between cyclin E and Ras but not Myc.
Oncogene. 1999 Dec 16;18(54):7816-24.

Schmidt T, Karsunky H, Rödel B, Zevnik B, Elsässer HP, Möröy T
Evidence implicating Gfi-1 and Pim-1 in pre-T-cell differentiation steps associated with beta-selection.
EMBO J. 1998 Sep 15;17(18):5349-59.

Lovec H, Grzeschiczek A, Kowalski MB, Möröy T
Cyclin D1/bcl-1 cooperates with myc genes in the generation of B-cell lymphoma in transgenic mice.
EMBO J. 1994 Aug 1;13(15):3487-95.

Möröy T, Grzeschiczek A, Petzold S, Hartmann KU.
Expression of a Pim-1 transgene accelerates lymphoproliferation and inhibits apoptosis in lpr/lpr mice.
Proc Natl Acad Sci U S A. 1993 Nov 15;90(22):10734-8.

Hsu T, Möröy T, Etiemble J, Louise A, Trepo C, Tiollais P, Buendia MA.
Activation of c-myc by woodchuck hepatitis virus insertion in hepatocellular carcinoma.
Cell. 1988 Nov 18;55(4):627-633

Möröy T, Marchio A, Etiemble J, Trepo C, Tiollais P, Buendia MA.
Rearrangement and enhanced expression of c-myc in hepatocellular carcinoma of hepatitis virus infected woodchucks.
Nature. 1986 Nov 20-26;324(6094):276-9.

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