The Clinic
Studying at IRCM
Core facilities
Cytoskeletal Organization and Cell Migration
Skip navigation links
Contact us

Research unit director

Premkumar L, Bobkov AA, Patel M, Jaroszewski L, Bankston LA, Stec B, Vuori K, Côté JF, Liddington RC. “Structural Basis of Membrane Targeting by the Dock180 Family of Rho Family Guanine Exchange Factors (Rho-GEFs).”  J Biol Chem 2010 285(17): 13211-13222

Côté JF, Vuori K. “Two lipids that give direction.” Science 2009, 324: 346
*Komander  D, Patel M,  Laurin M, Fradet N, Pelletier A, Barford  D, Côté JF. “An alpha-helical extension of the ELMO1 pleckstrin homology domain mediates direct interaction to DOCK180 and is critical in Rac signaling.” Mol Biol Cell 2008 19:  4837–4851 (Co-first authors)

Laurin M,  Fradet N, Blangy A, Hall A, Vuori K, Côté JF. “The atypical Rac activator Dock180 (Dock1) regulates myoblast
fusion in vivo
.” PNAS 2008  105 (40) : 15446-15451

Côté JF, Vuori K. “GEF what? Dock180 and related proteins help Rac to polarize cells in new ways.” Trends Cell Biol 2007 17(8): 383-393

Côté JF, Vuori K. “In Vitro Guanine Nucleotide Exchange Activity of DHR-2/DOCKER/CZH2 Domains.” Methods in Enzymology 2006 406: 41-57

Côté JF, Motoyama AB, Bush JA, Vuori K. “A novel and evolutionarily conserved PtdIns(3,4,5)P3-binding domain is necessary for DOCK180 signalling.” Nature Cell Biology 2005 7:797-807

Dail M, Kalo MS, Seddon JA, Côté JF, Vuori K, Pasquale EB. “SHEP1 Function in Cell Migration Is Impaired by a Single Amino Acid Mutation That Disrupts Association with the Scaffolding Protein Cas but Not with Ras GTPases.” J Bio Chem 2004 279(40): 41892-41902

Liu E, Côté JF, Vuori K.  "Negative regulation of FAK signaling by SOCS proteins.” The EMBO Journal 2003 22(19): 5036-5046

Côté JF, Vuori K. “Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity.” J Cell Sci  2002 115: 4901-13

All rights reserved: IRCM 2011_110 avenue des Pins Ouest - Montréal (Québec) H2W 1R7 – Canada