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Research unit director
Publications

1.  Hossain, D., and Tsang, W.Y.** (2014) Centrosome dysfunction and senescence: Coincidence or causality? Aging Sci. (in press) **corresponding author

2. Tsang, W.Y.**, and Dynlacht, B.D. (2013) CP110 and its network of partners coordinately regulate cilia assembly. Cilia 2: 9.

3. Barbelanne, M.  Song, J., Ahmadzai, M., and Tsang, W.Y.** (2013) Pathogenic NPHP5 mutations impair protein interaction with Cep290, a prerequisite for ciliogenesis. Hum. Mol. Genet. 22(12): 2482-2494.

4. Kobayashi, T.*, Tsang, W.Y.*, Li, J., Lane, W., and Dynlacht, B.D. (2011) Centriolar kinesin Kif24 interacts with CP110 to remodel microtubules and regulate ciliogenesis. Cell 145(6): 914-925. *equal contribution

5. Tsang, W.Y., Spektor, A., Vijayakumar, S., Bista, B., Li, J., Sanchez I., Duensing, S., and Dynlacht, B.D. (2009) Cep76, a centrosomal protein that specifically restrains centriole reduplication. Dev. Cell 16(5): 649-660.

6. Tsang, W.Y., Bossard, C., Khanna, H., Peränen, J., Swaroop, A., Malhotra, V., and Dynlacht, B.D. (2008) CP110 suppresses primary cilia formation through its interaction with CEP290, a protein deficient in human ciliary disease. Dev. Cell 15(2): 187-197.

7. Tsang, W.Y., and Dynlacht, B.D. (2008) sSgo1, a guardian of centriole cohesion. Dev. Cell 14(3): 320-322.

8. Tsang, W.Y., and Dynlacht, B.D. (2008) Double identity of SCAPER: a substrate and regulator of Cyclin A/Cdk2. Cell Cycle 7(6): 702-705.

9. Spektor, A., Tsang, W.Y., Khoo, D., and Dynlacht, B.D. (2007) Cep97 and CP110 suppress a cilia assembly program. Cell 130(4): 678-690.

10. Tsang, W.Y., Wang, L., Chen, Z., Sanchez, I., and Dynlacht, B.D. (2007) SCAPER, a novel cyclin A interacting protein that regulates cell cycle progression. J. Cell Biol. 178(4): 621-633. 

11. Tsang, W.Y., Spektor, A., Luciano, D.J., Indjeian, V.B., Chen, Z., Salisbury, J.L., Sanchez, I., and Dynlacht, B.D. (2006) CP110 cooperates with two calcium-binding proteins to regulate cytokinesis and genome stability. Mol. Biol. Cell 17(8): 3423-3434.

12. Tsang, W.Y., and Lemire, B.D. (2003) The role of mitochondria in the life of the nematode, Caenorhabditis elegans. Biochim. Biophys. Acta. 1638(2): 91-105.

13. Artal Sanz, M., Tsang, W.Y., Willems, E.M., van der Spek, H., Grivell, L.A., Lemire, B.D., and Nijtmans, L.G. (2003) The mitochondrial prohibitin complex is essential for embryonic viability and germline function in Caenorhabditis elegans. J. Biol. Chem. 278(34): 32091-32099.

14. Tsang, W.Y., and Lemire, B.D. (2003) The mitochondrial ATP synthase controls larval development cell non-autonomously in Caenorhabditis elegans. Dev. Dyn. 226(4): 719-726.

15. Tsang, W.Y., and Lemire, B.D. (2002) Stable heteroplasmy but differential inheritance of a large mitochondrial DNA deletion in nematodes. Biochem. Cell Biol. 80(5): 645-654.

16. Tsang, W.Y., and Lemire, B.D. (2002) Mitochondrial genome content is regulated during nematode development. Biochem. Biophys. Res. Commun. 291(1): 8-16.

17. Tsang, W.Y., Sayles, L.C., Grad, L.I., Pilgrim, D.B., and Lemire, B.D. (2001) Mitochondrial respiratory chain deficiency in Caenorhabditis elegans results in developmental arrest and increased life span. J. Biol. Chem. 276(34): 32240-32246.

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