Bourgeois, R., Mercier, J., Paquette-Brooks, I.U and Cohen, E.A. Association between disruption of CD4 receptor dimerization and increased human immunodeficiency virus type 1 entry. Retrovirology 3: 31, June 8, 2006.Finzi, A., Brunet, A., Xiao, Y., Thibodeau, J. and Cohen, E.A. MHC-II molecules promote HIV-1 assembly and budding to late endosomal/multivesicular body compartments. J. Virol. 80(19): 9789-9797, October 2006.Gatignol, A., Dubuisson, J., Wainberg, M.A., Cohen, E.A. and Darlix, J.L.New pandemics: HIV and AIDS, HCV and chronic hepatitis, Influenza virus and flu. Retrovirology 4: 8, February 1, 2007
Welman, M., Lemay, G. and Cohen, E.A. Role of envelope processing and gp41 membrane spanning domain in the formation of human immunodeficiency virus type 1 (HIV-1) fusion-competent envelope glycoprotein complex. Virus Res. 124: 103-112, March 2007
Jones, G.J., Barsby, N.L., Cohen, E.A., Holden, J., Harris, K., Dickie, P., Jhamandas, J. and Power, C.HIV-1 Vpr causes neuronal apoptosis and in vivo neurodegeneration. J. Neurosci. 27(14): 3703-3711, April 4, 2007
Finzi, A., Orthwein, A., Mercier, J. and Cohen, E.A. Productive human immunodeficiency virus type 1 assembly takes place at the plasma membrane. J. Virol. 81(14): 7476-7490, July 2007
*Belzile, J.-P., *Duisit, G., Mercier, J., Rougeau, N., Finzi, A. and Cohen, E.A. HIV-1 Vpr-mediated G2 arrest involves the DDB1-Cul4AVprBP E3 ubiquitin ligase. PLoS Pathogens. 3(7): e85, July 2007*Contributed equally to this work
Binette, J., Dubé, M., Mercier, J., Halawani, D., Latterich, M. and Cohen, E.A. Requirements for the selective degradation of CD4 receptor molecules by the human immunodeficiency virus type 1 Vpu protein in the endoplasmic reticulum. Retrovirology 4: 75, October 15, 2007
Westerman, K.A., Ao, Z., Cohen, E.A. and Leboulch, P. Design of a trans protease lentiviral packaging system that produces high titer virus. Retrovirology 4: 96, December 28, 2007
Xiao, Y., Chen, G., Richard, J., Rougeau, N., Li, H., Seidah, N.G. and Cohen, E.A. Cell-surface processing of extracellular human immunodeficiency virus type 1 Vpr by proprotein convertase. Virology 372(2): 384-397, March 15, 2008
Krueger, B., Jeronimo, C., Roy, B.BU, Bouchard, A., Barrandon, C., Byers, S., Cooper, J., Bensaude, O., Cohen, E.A., Coulombe, B. and Price, D. LARP7 is a stable component of the 7SK snRNP while P-TEFb, HEXIM1 and hnRNP A1 are reversibly associated. Nucleic Acids Res. 36(7): 2219-2229, April 16, 2008
Xu Z., Zheng Y., Ao Z., Clement M., Mouland A.J., Kalpana G.V., Belhumeur P., Cohen E.A., and Yao, X.-J. Contribution of the C-terminal region within the catalytic core domain of HIV-1 integrase to yeast lethality, chromatin binding and viral replication. Retrovirology 5: 102, published on line, November 14, 2008
Dubé, M., Roy, B.B, Guiot-Guillain, P., Mercier, J., Binette, J., Leung, G., J. and Cohen, E.A. Suppression of Tetherin-restricting activity upon HIV-1 particle release correlates with localization of Vpu in the trans-Golgi network. J. Virol. 83(9): 4574-4590, May 2009. doi:10.1128/JVI.01800-08
Bego, M., Dubé, M., Mercier, J. and Cohen, E.A. Effect of calcium-modulating cyclophilin ligand (CAML) on HIV-1 particle release and cell surface expression of tetherin. J. Virol : 83 (24)13032-13036, December 2009. Published ahead of print on September 30, 2009. doi:10.1128/JVI.01786-09
Yang, Y-X., Guen, V. Richard, J. Cohen, E.A. and Berthoux, L. Cell context-dependent involvement of ATR in early stages of retroviral replication. Virology 396: 272-279, published ahead of print on November, 13, 2009 as doi: 10.1016/j.virol.2009.10.032
Richard, J., Sindhu, S., Pham, T. NQ, Belzile, J-P and Cohen, EA. HIV-1 Vpr up-regulates expression of ligands for the activating NKG2D receptor and promotes NK cell-mediated killing. Blood: 115: 1354-1363, February 2010. Published online as Blood First Edition December 14, 2009 as doi: 10.1182/blood-2009-08-237370
Belzile, J.-P., Richard, J., Rougeau, N., Xiao, Y., and Cohen, E.A. HIV-1 Vpr induces the K48-linked polyubiquitination and proteasomal degradation of target cellular proteins to activate ATR and promote G2 arrest. J. Virol.:84, 3320-3330, April 2010 published ahead of print on 20 January 2010 as doi:10.1128/JVI.02590-09
Noorbakhsh, F., Ramachandran, R., Barsby, N., Ellestad, K., Leblanc, A., Dickie, P., Baker, G., Hollenberg, M.D., Cohen, E.A. and Power, C. MicroRNA profiling reveals new aspects of HIV neurodegeneration: caspace-6 regulates astrocyte survival. FASEB J. 24: 1799-1812, June 2010. First published on January 28, 2010 as doi 10 1096/fj.09-147819
Dubé, M., Roy, B.B., Guiot-Guillain, P., Binette, J., Mercier, J., Chiasson, A. and Cohen, E.A. Antagonism of tetherin restriction of HIV-1 release by Vpu involves binding and sequestration of the restriction factor in a perinuclear compartment. PLoS Pathogens 6(4): e1000856. April 2010
Ao, Z., Danappa, J.K., Wang, B., Zheng, Y., Kung, S., Rassart, E., Depping, R., Kohler, M., Cohen, E.A. and Yao, X. Importin α3 interacts with HIV-1 integrase and contributes to HIV-1 nuclear import and replication. J. Virol. doi:10.1128/JVI.00508-10. Published ahead of print on 16 June 2010
Acharjee, S., Noorbakhsh, F., Stemkowski, P.L., Olechowski, C., Cohen, E.A., Ballanyi, K., Kerr, B., Pardo, C., Smith, P. A. and Power, C. HIV-1 viral protein R causes peripheral nervous system injury associated with in vivo neuropathic pain. FASEB J. First published on July 13, 2010 as doi:10.1096/fj.10-162313
*Belzile, J-P, *Abrahamyan, L.G., Gerard, F. C.A, Rougeau, N. and Cohen, E.A. Formation of mobile chromatin-associated nuclear foci containing HIV-1 Vpr and VPRBP is critical for the induction of G2 cell cycle arrest. PLoS Pathogens. 6(9): e1001080. doi:10.1371/journal.ppat.1001080*Ont contribué également à ce travail. Vivithanaporn, P., Maingat, F., Lin, L-T., Na, H., Richardson, C.D., Agrawal, B., Cohen, E.A., Jhamandas, J.H., Power, C. Hepatitis C Virus Core Protein Induces Neuroimmune Activation and Potentiates Human Immunodeficiency Virus-1 Neurotoxicity. PLoS ONE 5(9): e 12856. doi:10.1371/journal.pone.0012856
Richard, J., Cohen, E.A. HIV-1 Vpu disarms NK cells. Cell Host and Microbe, 8(5): 389-391 November 18, 2010. doi:10.1016/j.chom.2010.11.001
Dubé, M., Bego, M., and Paquay, C., Cohen, E.A. Modulation of HIV-host interactions: role the Vpu accessory protein. Retrovirology, December, 22, 2010. doi:10.1186/1742-4690-7-114.Sélectionné par « Retrovirology » comme article très consulté.
Maingat, F., Halloran, B., Acharjee, A., van Marle, G., Church, A.D., Gill, J., Uwiera, R., Cohen, E.A., Meddings, J., Madsen, K., and Power, C. Inflammation and intestinal epithelial cell injury in AIDS enteropathy: a role of endoplasmic reticulum stress. FASEB J. First published on March 22, 2011
Na, H., Archarjee, S., Jones, G., Vivithanaporn, P. Noorbakhsh, F., Barsby, N. Maingat, N., Ballanyi, K., Pardo, C., Cohen, E.A. and Power, C. Interactions between human immunodeficiency virus (HIV)-1 Vpr expression and innate immunity influence neurovirulence. Retrovirology 8: 44, June 6, 2011. doi:10.1186/1742-4690-8-44Wainberg, M.A. and Cohen E.A. Jean-Luc Darlix: Renaissance scientist and retrovirologist par excellence. Retrovirology 8 :59, July 18, 2011. doi:10.1186/1742-4690-8-59Mukerjee, R., Chang, J.R, Del Valle, L., Bagashev, A., Gayed, M.M., Lyde, R.B., Hawkins, B.J, Brailoiu, E., Cohen, E., Power, C. Azizi, S.A., Gelman, B.B., and Sawaya, B.E. Deregulation of microRNAs by HIV-1 Vpr leads to the development of neurocognitive disorders. J. Biol. Chem. Published on line, August 4, 2011Dubé, M., Paquay, C., Roy, B.B., Bego, M., Mercier, J., and Cohen E.A. HIV-1 Vpu antagonizes BST-2 by interfering mainly with the trafficking of newly synthesized BST-2 to the cell surface. Traffic, published on line September 8th, 2011. Dec;12(12):1714-29. doi: 10.1111/j.1600-0854.2011.01277
Pham, T. N.Q., Richard, J., Gerard, F., Power, C., and Cohen, E.A. Modulation of NKG2D-Mediated Cytotoxic Functions of Natural Killer Cells by Viral Protein R (Vpr) from HIV-1 Primary Isolates . J. Virol., 85: 12254-12261, published on line, September 28, 2011.DOI: 10.1128/JVI.05835-11
Bego, M., Mercier, J., and Cohen, E.A. Virus-activated IRF-7 up-regulates expression of the interferon-regulated BST2 gene independently of interferon signalling. J. Virol., 86: 3513-3527, Published ahead of print 1 February 2012, doi:10.1128/JVI.06971-11.
Boily-Larouche, G., Milev, M.P, Zijenah, L.S., Labbé, A-C., Zannou, M.D., Humphrey, J.H., Ward, B.J., Poudrier, J., Mouland, A.J., Cohen É.A., and Roger, M. Naturally occurring genetic variants in human DC-SIGN increase HIV-1 capture, cell-transfer and risk of mother-to-child transmission. PLoS ONE 7(7): e40706. doi:10.1371/journal.pone.0040706
Ferrucci, A., Nonnemacher, M.R., Cohen, E.A. and Wigdahl, B. Extracellular HIV-1 Vpr causes ATP and glutathione declines in an astrocytic cell line compromising the antioxidant reservoir. Virus Research 167:358-369, Epub 2012 June 9.
Romani, B. and Cohen, E.A. Lentivirus Vpr and Vpx accessory proteins usurp the Cullin4-DDB1 (DCAF1) E3 ubiquitin ligase. Current Opinion in Virology 2(6): 755-763, published on line on October 10, 2012. Doi: 10.1016/j.coviro.2012.09.010.
*Finzi, A., *Perlman, M., Bourgeois-Daigneault, M-C, Thibodeau, J., Cohen, E.A. MHC-II molecules promote targetting of HIV-1 virions in late endosomes by enhancing internalization of nascent particles from the plasma membrane. Cell Microbiol 15: 809-822, 2013, published on line on November 21, 2012. doi: 10.1111/cmi.12074. *Contributed equally to this work.
Polyak, M.J., Vivithanaporn, P., Maingat, F.G., Branton, W., Cohen, E.A, Meeker, R., and Power, C. Differential type 1 interferon-regulated gene expression in the brain during AIDS: interactions with viral diversity and neurovirulence. FASEB J 27: 2829-2844. published on line on April 22, 2013. doi: 10.1096/fj.13-227868.
Baril, M., Es-Saad, S., Chatel-Chaix, L., Fink, K, Pham, TNQ, Raymond, V-A, Audette, K., Guenier, A-M, Duchaine, J., Servant, M., Bilodeau, M., Cohen, E.A., Grandvaux, N., and Lamarre, D. Genome-wide RNAi screen reveals a new role of a WNT/CTNNB1 signaling pathway as negative regulator of virus-induced innate immune responses. PLoS Pathogens. 9(6): e1003416, June 13, 2013. doi:10.1371/journal.ppat.1003416.
Richard, J, Pham, TNQ, Ishizaka, Y, and Cohen, E.A. Viral Protein R upregulates expression of ULBP2 on uninfected bystander cells during HIV-1 infection of primary CD4+ T lymphocytes. Virology 443: 248-256, published on line May 31 2013. doi:10.1016/j.virol.2013.04.037.
Monette, A.*, Valiente-Echeverría, F.*, Rivero, M., Cohen, E.A., Lopez-Lastra, M. and. Mouland, A.J. Dual mechanisms of translation initiation of the full-length HIV-1 mRNA contribute to Gag synthesis. PLoS One. 8(7): e68108. doi:10.1371/journal.pone.0068108. *Contributed equally to this work.
Vassena, L., Giuliani, E., Matusali, G., Cohen, E.A., and Doria, M. The human immunodeficiency virus type 1 Vpr protein up-regulates PVR via the activation of the ATR-mediated DNA damage response pathway. J. Gen. Virol. Published September 17, 2013 as doi:10.1099/vir.0.055541-0. PMID 24045107.
Dave, V.P., Hajjar, F., Dieng, M., M,. Haddad, É., and Cohen, E.A. Efficient BST2 antagonism by Vpu is critical for early HIV-1 dissemination in humanized mice. Retrovirology 10: 128 November 6, 2013. DOI: 10.186/1742-4690-10-128. PMID 24195843
Pham, T.N.Q., Lukhele, S., Hajjar, F., Routy, J-P, and Cohen, E.A. HIV Nef and Vpu Protect HIV-Infected CD4+ T Cells from Antibody-Mediated Cell Lysis through Down-modulation of CD4 and BST2. Retrovirology 11: 15, February 6, 2014. DOI:10.1186/1742-4690-11-15. PMID: 24498878. Selected by Retrovirology as a highly accessed article
Cohen, E.A. From Arrest to Escape: HIV-1 Vpr cuts a deal. Cell Host and Microbe 15: 125-127 Published online, February 12, 2014. doi.org/10.1016/j.chom.2014.01.012. PMID: 24528857
Gérard, F.C.A, Yang, R., Poisson, A., Belzile, J-P., Rougeau, N., and Cohen, E.A. Defining the Interactions and Role of DCAF1/VPRBP in the DDB1-Cullin4A E3 Ubiquitin Ligase Complex Engaged by HIV-1 Vpr to Induce a G2 Cell Cycle Arrest. PLoS ONE 9(2): e89195 Published online February 18, 2014. doi:10.1371/journal.pone.0089195. PMID: 24558487