Woong-Kyung Suh, PhD
One of Dr. Suh’s primary objectives is to advance our understanding of the signalling mechanisms of CD28 and ICOS T cell costimulation receptors. Specifically, his team is investigating the phosphoinositide 3-kinase pathway using a panel of knockout and knockin mice for the signalling intermediary. His research unit is also interested in the role of T cell costimulation in cancer immunity. A member of the B7 costimulating molecule family, molecule B7-H4, inhibits T cell immunity. Since B7-H4 is strongly overexpressed in breast cancer in humans, it is possible that it helps tumour cells to avoid immune attacks. Dr. Suh’s team is currently developing lineages of transgenic mice to test that hypothesis.
Dr. Suh holds a New Investigator Award from the Canadian Institutes of Health Research (CIHR).
Degrees and relevant experience