Woong-Kyung Suh, PhD
One of our primary objectives is to understand the signaling mechanisms of a T cell costimulatory receptor ICOS, lack of which is known to cause immunodeficiency in humans and mice. Specifically, we are investigating the phosphoinositide 3-kinase and calcium signaling pathways through biochemical, flow cytometric, and imaging techniques using gene-targeting mouse models. We are also interested in the role of T cell costimulation in cancer immunity. Several members of the B7 family of costimulatory ligands are highly overexpressed in multiple human cancers but their roles in cancer-immune interactions remain poorly understood. Through bioinformatics analysis of human cancer genome databse and experiments using mouse cancer models, we are trying to define the role of B7-H3 and B7-H4 in anti-cancer T cell immunity and immune-evasive capacity of cancer cells.
Degrees and relevant experience