The Clinic
Studying at IRCM
Core facilities
Immune Regulation
Skip navigation links
Lab photos
Contact us

Home > Immune Regulation > Director
Home > Immune Regulation > Director
Research unit director

Woong-Kyung Suh, PhD

  • Director, Immune Regulation Research Unit
  • Associate IRCM Research Professor
  • Associate Research Professor, Department of Medicine (accreditation in the Department of Microbiology, Infectiology and Immunology, and the Molecular Biology Program), Université de Montréal
  • Adjunct Professor, Department of Medicine (Division of Experimental Medicine), and Adjunct Member, Department of Microbiology and Immunology, McGill University

When T cells of the immune system encounter antigens, they should decide whether they have to develop immunity or tolerance. One of the key factors that critically influence this decision making process is costimulation. Thus, we are studying T cell costimulatory signaling mechanisms with an aim to boost immunity against infection and cancer or suppress pathogenic immune reactions in the settings of autoimmunity and organ transplantation.

One of our primary objectives is to understand the signaling mechanisms of a T cell costimulatory receptor ICOS, lack of which is known to cause immunodeficiency in humans and mice. Specifically, we are investigating the phosphoinositide 3-kinase and calcium signaling pathways through biochemical, flow cytometric, and imaging techniques using gene-targeting mouse models.  We are also interested in the role of T cell costimulation in cancer immunity. Several members of the B7 family of costimulatory ligands are highly overexpressed in multiple human cancers but their roles in cancer-immune interactions remain poorly understood.  Through bioinformatics analysis of human cancer genome databse and experiments using mouse cancer models, we are trying to define the role of B7-H3 and B7-H4 in anti-cancer T cell immunity and immune-evasive capacity of cancer cells.

Degrees and relevant experience

  • PhD in Biochemistry, University of Toronto
  • PDF in Molecular Immunology, Harvard University
  • PDF in Immunology and Cancer, Ontario Cancer Institute
All rights reserved: IRCM 2011_110 avenue des Pins Ouest - Montréal (Québec) H2W 1R7 – Canada