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Home > Molecular Oncology > Publications
Home > Molecular Oncology > Publications
Research unit director
Publications

RECENT PUBLICATIONS I SELECTION OF PREVIOUS PUBLICATIONS

Zhong, M-C. and Veillette, A.
The adaptor molecule SAP is essential in mechanisms involving the Fyn tyrosine kinase for the induction and progression of collagen-induced arthritis.
J Biol Chem. 2013 Sep 17. (Epub ahead of print).

Rhee, I., Davidson, D., Souza, C.M., Vacher, J. and Veillette, A.
Macrophage fusion is controlled by the cytoplasmic protein tyrosine phosphatase PTP-PEST/PTPN12.
Mol. Cell. Biol., 2013 Jun; 33(12): 2458-69.

Veillette, A. and Guo, H.
CS1, a SLAM family receptor involved in immune regulation, is a therapeutic target in multiple myeloma.
Crit. Rev. Oncol. Hematol., Epub 2013 May; doi: 10.1016/j.critrevonc.2013.04.003.

Das, R., Bassiri, H., Guan, P., Wiener, S., Banerjee, P., Zhong, M.-C, Veillette, A., Orange, J. S. and Nichols, K. E.
The adaptor molecule SAP plays essential roles during invariant NKT cell cytotoxicity and lytic synapse formation.
Blood., 2013 April 25; 121(17): 3386-95.

Zhong, M.-C. and Veillette, A.
Critical role of SAP in progression and re-activation, but not maintenance, of T cell-dependent humoral immunity.
Mol. Cell. Biol.; 2013 Mar; 33(6): 1223-32.

Souza, C.M., Rhee, I., Gratton, J.-P., Davis, E.C. and Veillette, A.
The phosphatase PTP-PEST/PTPN12 regulates endothelial cell migration and adhesion, but not permeability, and controls vascular development and embryonic viability.
J. Biol. Chem. 2012 Dec; 287(51): 43180-43190.

Hauck, F., Randriamampita, C., Martin, E., Gerart, S., Lambert, N., Lim, A., Soulier, J., Maciorowski, Z., Touzot, F., Moushous, D., Quartier, P., Heritier, S., Blanche, S., Rieux-Laucat, F., Brousse, N., Callebaut, I., Veillette, A., Hivroz, C., Fischer, A., Latour, S. and Picard, C.
Primary T-cell immunodeficiency with immunodysregulation caused by autosomal recessive Lck deficiency.
J. Allergy Clin. Immunol., 2012 Nov; 130(5): 1144-1152.

Dong, Z., Davidson, D., Perez-Quintero, L.-A., Kurosaki, T., Swat, W. and Veillette, A.
The SAP adaptor controls NK cell activation by regulating the enzymes Vav-1 and SHIP-1 and by enhancing conjugates with target cells.
Immunity, 2012 June; 36(6): 974-85

Guimont-Desrochers, F., Boucher, G., Dong, Z., Dupuis, M., Veillette, A. and Lesage, S.
Redefining interferon-producing killer dendritic cells as a novel intermediate in NK cell differentiation.
Blood, 2012 May; 119(19): 4349-57.

Zhong, M.-C. and Veillette A.
Csk keeps LYP on a leash.
Nature Chemical Biology, 2012 Apr 17; 8(5): 412-13.

Rhee, I. and Veillette A.
Protein tyrosine phosphatases in lymphocyte activation and autoimmunity.
Nature Immunology; 2012 Apr; 13(5): 439-47.

Wu, N. and Veillette A.
Immunology: Magnesium in a signaling role.
Nature, 2011 July; 475(7357): 471-6.

Dong, Z. and Veillette, A.
How do SAP family deficiencies compromise immunity?
Trends in Immunology, 2010 Aug; 31(8): 295-302.

Davidson, D., Shi, X. Zhong, M.-C., Rhee I., Veillette, A.
The phosphatase PTP-PEST promotes secondary T cell responses by dephosphorylating the protein  tyrosine kinase Pyk2.
Immunity, 2010 Aug; 33: 1-14.

Cruz-Munoz, M.E. and Veillette, A.
Do NK cells always need a license to kill?
Nat Immunol, News and Views; 2010 Apr; 11 (4): 279-80.

Veillette, A.
SLAM  family receptors: immune regulators with or without SAP family adaptors.
Cold Spring Harb Perspect Biol, 2010 Mar; 2 (3): a002469.

Dong, Z., Cruz-Munoz, M.-E., Zhong, M.-C., Chen, R., Latour, S., Veillette, A.
Essential function for SAP family adaptors in the surveillance of hematopoietic cells
by natural killer cells.
Nature Immunol, 2009; 10: 973-980.

Veillette, A.
Organization of immunoreceptor signaling by adapters.
Immunol Rev, 2009; 232: 5-6.

Veillette, A., Dong, Z., Pérez-Quintero, L.-A., Zhong, M.-C., Cruz-Munoz, M.-E.
Importance and mechanism of `switch`function of SAP family adapters.
Immunol Rev, 2009; 232: 229-239.

Veillette, A., Rhee, I., Martins Souza, C., Davidson, D.
PEST family phosphatases in immunity, autoimmunity, and autoinflammatory disorders.
Immunol Rev, 2009; 228: 312-324.

Cruz-Munoz, M.E., Dong, Z., Shi, X., Zhang, S., Veillette, A.
Influence of CRACC, a SLAM family receptor coupled to the adaptor EAT-2, on natural
killer cell function.
Nat Immunol, 2009 Mar; 10 (3): 297-305.

Nunez-Cruz, S., Yeo, W.C.J., Rothman, J., Ojha, P., Bassiri, H., Juntilla, M.,
Davidson, D., Veillette, A., Koretzky, G.A., Nichols, K.E.
Differential requirement for the SAP-Fyn interaction during NK T cell development and
function.
J. Immunol., 2008 Aug 15; 181 (4): 2311-2320.

Filipp, D., Moemeni, B, Ferzoco, A., Kathirkamathamby, K., Zhang, J., Ballek, O.,
Davidson, D., Veillette, A. and Julius, M.
LCK dependent Fyn activation requires
C-terminus dependent targeting of kinase active LCK to lipid rafts.
J. Biol. Chem., Sept 2008; 283 (39): 26409-26422.

Zhong, M.-C. and Veillette, A.
Control of T lymphocyte signaling by Ly108, a SLAM family receptor implicated in
auto-immunity.
J. Biol. Chem., Jul 2008; 283 (28): 19255 - 19264.

Veillette, A., Zhang, S., Shi, X., Dong, Z., Davidson, D., and Zhong, M.-C.
SAP expression in T cells, not in B cells, is required for humoral immunity.
Proc. Natl. Acad. Sci. USA 2008; 105:1273-1278.

Veillette, A., Dong, Z., and Latour, S.
Consequence of the SLAM-SAP signaling pathway in innate-like and conventional
lymphocytes.
Immunity 2007; 27: 698-710.

Davidson, D., Schraven, B. and Veillette, A.
PAG-associated FynT regulates calcium signaling and promotes anergy in T lymphocytes.
Mol. Cell. Biol. 2007; 27:1960-1973.

Veillette, A.
NK cell regulation by SLAM family receptors and SAP-related adapters.
Immunol Rev. 2006; 214:22-34.

Dong, S., Corre, B., Foulon, E., Dufour, E., Veillette, A., Acuto, O. and Michel, F.
T cell receptor for antigen induces linker for activation of T cell-dependent
activation of a negative signaling complex involving Dok-2, SHIP-1, and Grb-2.
J. Exp Med. 2006; 203:2509-18.

Chen, R., Latour, S., Shi, X. and Veillette, A.
Association between SAP and FynT: inducible SH3 domain-mediated interaction controlled
by engagement of the SLAM receptor.
Mol. Cell. Biol. 2006; 26: 5559-5568.

Veillette, A., Cruz-Munoz, M.E. and Zhong, M.C.
SLAM family receptors and SAP-related adaptors: matters arising.
Trends Immunol. 2006; 27:228-234.

Veillette, A.
Immune regulation by SLAM family receptors and SAP-related adaptors.
Nat. Rev. Immunol. 2006; 6:56-66.

Roncagalli, R. and Veillette. A.
EAT-2: un nouveau régulateur de la fonction des cellules NK (EAT-2: a novel regulator of natural killer cell functions).
Med. Sci. (Paris) 2005; 22:22-24.

Maksumova, L., Le, H.T., Muratkhodjaev, F., Davidson, D., Veillette, A., and Pallen, C.J.
Protein tyrosine phosphatase alpha regulates Fyn activity and Cbp/PAG phosphorylation
in thymocyte lipid rafts.
J. Immunol. 2005; 175 :7947-7956.

Roncagalli, R., Taylor, J.E.R., Zhang, S., Shi, X., Chen, R., Cruz-Munoz, M.E., Yin, L., Latour, S., and Veillette, A.
Negative regulation of NK cell functions by EAT-2, a SAP-related adaptor.
Nat Immunol 2005; 6L1002-1010.

Bloch-Queyrat, C., Fondanèche, M.-C., Chen, R., Yin, L., Relouzat, F., Veillette, A., Fisher, A., and Latour, S.
Regulation of natural cytotoxicity by the adapter SAP and the Src-related kinase Fyn.
J. Exp. Med. 2005;202:1-13.

Arnold R., Patzak I.M., Neuhaus B., Vancauwenbergh S., Veillette, A., Van Lint, J., and Kiefer, F.
Activation of hematopoietic progenitor kinase 1 (HPK1) involves relocation,
autophosphorylation and transphosphorylation by PKD1.
Mol Cell Biol. 2005;25 :2364-2383.

 

 I RECENT PUBLICATIONS 

Davidson, D., Shi X., Zhang, S. Wang, H., Nemer, M., Ono, N., Ohno, S., Yanagi, Y and Veillette A.
Genetic evidence linking SAP, the X-linked lymphoproliferative gene product, to Src-related kinase FynT in TH2 cytokine regulation.
Immunity 2004;21:707-717.

Chen, R., Relouzat, F., Roncagalli, R., Aoukaty, Al, Tan, R., Latour, S. and Veillette, A.
Molecular dissection of 2B4 signalling: implications for signal transduction by SLAM-related receptors.
Mol. Cell. Biol. 2004; 24:5144-5156.

Davidson, D., Bakinowski, M., Thomas, M.L., Horejsi, V. and Veillette, A.
Phosphorylation-dependent regulation of T-cell activation by PAG/Cbp, a lipid raft-associated transmembrane adaptor.
Mol. Cell. Biol. 2003;23:2017-2028.

Latour, S., Roncagalli, R., Chen, R., Bakinowski, M., Shi, X., Schwartzberg, P.L., Davidson, D. and Veillette, A.
Binding of SAP SH2 domain to FynT SH3 domain reveals a novel mechanism of receptor signalling in immune regulation.
Nat. Cell. Biol. 2003;5:149-154.

Veillette, A., Latour, S. and Davidson, D.
Negative regulation of immunoreceptor signalling.
Annu. Rev. Immunol. 2002;20:669-707.

Latour, S., Gish, G., Helgason, C.D., Humphries, R.K., Pawson, T. and Veillette, A.
Regulation of SLAM-mediated signal transduction by SAP, the X-linked lymphoproliferative gene product.
Nat. Immunol. 2001;2:681-690.

Davidson, D. and Veillette, A.
PTP-PEST, a scaffold protein tyrosine phosphatase, negatively regulates lymphocyte activation by targeting a unique set of substrates.
EMBO J. 2001;20:3414-3426.

Lemay, S., Davidson., D., Latour, S. and Veillette, A.
Dok-3, a novel adapter molecule involved in the negative regulation of immunoreceptor signaling.
Mol. Cell. Biol. 2000;20:2743-2754.

Cao, M.Y., Davidson, D., Yu, J., Latour, S. and Veillette, A.
Clnk, a novel SLP-76-related adaptor molecule expressed in cytokine-stimulated hemopoietic cells.
J. Exp. Med. 1999;190:1527-1534.

Cloutier, J.-F. and Veillette, A.
Cooperative inhibition of T-cell antigen receptor signaling by a complex between a kinase and a phosphatase.
J. Exp. Med. 1999;189:111-121.

Latour, S., Zhang, J., Siraganian, R.P. and Veillette, A.
A unique insert in the linker domain of Syk is necessary for its function in immunoreceptor signalling.
EMBO J. 1998;17:2584-2595.

Latour, S., Fournel, M. and Veillette, A.
Regulation of T-cell antigen receptor signalling by Syk tyrosine protein kinase.
Mol. Cell. Biol. 1997;17:4434-4441.

Cloutier, J.-F. and Veillette, A.
Association of inhibitory tyrosine protein kinase p50csk with protein tyrosine phosphatase PEP in T cells and other hemopoietic cells.
EMBO J. 1996;15:4909-4918.

Fournel, M., Davidson, D., Weil, R. and Veillette, A.
Association of tyrosine protein kinase Zap-70 with the protooncogene product p120c-cbl in T lymphocytes.
J. Exp. Med. 1996;183:301-306.

Davidson, D., Viallet, J. and Veillette, A.
Unique catalytic properties dictate the enhanced function of p59fynT, the hemopoietic cell-specific isoform of the Fyn tyrosine protein kinase, in T cells.
Mol. Cell. Biol. 1994;14:4554-4564.

Chow, L.M.L., Fournel, M., Davidson, D. and Veillette, A.
Negative regulation of T-cell receptor signalling by tyrosine protein kinase p50csk.
Nature 1993;365:156-160.

Davidson, D., Chow, L.M.L., Fournel, M. and Veillette, A.
Differential regulation of T cell antigen responsiveness by isoforms of the src-related tyrosine protein kinase p59fyn.
J. Exp. Med. 1992;175:1483-1492.

Abraham, N., Miceli, M.C., Parnes, J.R. and Veillette, A.
Enhancement of T-cell responsiveness by the lymphocyte-specific tyrosine protein kinase p56lck.
Nature 1991;350:62-66.

Veillette, A., Zuniga-Pflücker, J.C., Bolen, J.B. and Kruisbeek, A.M.
Engagement of CD4 and CD8 expressed on immature thymocytes induces activation of intracellular tyrosine phosphorylation pathways.
J. Exp. Med. 1989;170:1671-1680.

Veillette, A., Bookman, M.A., Horak, E.M., Samelson, L.E. and Bolen, J.B.
Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck.
Nature 1989;338:257-259.

Veillette, A., Bookman, M.A., Horak, E.M. and Bolen, J.B.
The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck.
Cell 1988;55:301-308.

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