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Home > Molecular Oncology > Publications
Home > Molecular Oncology > Publications
Research unit director
Publications

RECENT PUBLICATIONS I SELECTION OF PREVIOUS PUBLICATIONS

Guo, H., Cruz-Munoz, M.E., Wu, N., Robbins, M. and Veillette, A.
Immune cell inhibition by SLAMF7 is mediated by mechanism requiring Src kinases, CD45 and SHIP-1 defective in multiple myeloma cells.
Mol Cell Biol. 2014 Oct 13. pii: MCB.01107-14. [Epub ahead of print]

Veillette, A. and Davidson, D.
Immunology: When lymphocytes run out of steam.
Nature. 2014 Jun 12; 510(7504):222-3.

Perez-Quintero, L.A, Roncagalli, R., Guo, H., Latour, S., Davidson, D., and Veillette, A.
EAT-2, a SAP-like adaptor, controls NK cell activation through phospholipase Cγ, Ca++, and Erk, leading to granule polarization.
J Exp Med. 2014 Apr7; 211(4): 727-42.

Rhee, I., Zhong, M-C., Reizis, B., Cheong, C. and Veillette, A.
Control of dendritic cell migration, T cell-dependent immunity, and autoimmunity by protein tyrosine phosphatase PTPN12 expressed in dendritic cells.
Mol Cell Biol. 2014 Mar; 34(5): 888-99.

Zhong, M-C. and Veillette, A.
The adaptor molecule signaling lymphocytic activation molecule (SLAM)-associated protein (SAP) is essential in mechanisms involving the Fyn tyrosine kinase for the induction and progression of collagen-induced arthritis.

J Biol Chem. 2013 Nov 1; 288(44):31423-36. 

Rhee, I., Davidson, D., Souza, C.M., Vacher, J. and Veillette, A.
Macrophage fusion is controlled by the cytoplasmic protein tyrosine phosphatase PTP-PEST/PTPN12.
Mol. Cell. Biol., 2013 Jun; 33(12): 2458-69.

Veillette, A. and Guo, H.
CS1, a SLAM family receptor involved in immune regulation, is a therapeutic target in multiple myeloma.
Crit. Rev. Oncol. Hematol., 2013 Oct;88(1):168-77.

Das, R., Bassiri, H., Guan, P., Wiener, S., Banerjee, P., Zhong, M.-C, Veillette, A., Orange, J. S. and Nichols, K. E.
The adaptor molecule SAP plays essential roles during invariant NKT cell cytotoxicity and lytic synapse formation.
Blood., 2013 April 25; 121(17): 3386-95.

Zhong, M.-C. and Veillette, A.
Critical role of SAP in progression and re-activation, but not maintenance, of T cell-dependent humoral immunity.
Mol. Cell. Biol.; 2013 Mar; 33(6): 1223-32.

Souza, C.M., Rhee, I., Gratton, J.-P., Davis, E.C. and Veillette, A.
The phosphatase PTP-PEST/PTPN12 regulates endothelial cell migration and adhesion, but not permeability, and controls vascular development and embryonic viability.
J. Biol. Chem. 2012 Dec; 287(51): 43180-43190.

Hauck, F., Randriamampita, C., Martin, E., Gerart, S., Lambert, N., Lim, A., Soulier, J., Maciorowski, Z., Touzot, F., Moushous, D., Quartier, P., Heritier, S., Blanche, S., Rieux-Laucat, F., Brousse, N., Callebaut, I., Veillette, A., Hivroz, C., Fischer, A., Latour, S. and Picard, C.
Primary T-cell immunodeficiency with immunodysregulation caused by autosomal recessive Lck deficiency.
J. Allergy Clin. Immunol., 2012 Nov; 130(5): 1144-1152.

Dong, Z., Davidson, D., Perez-Quintero, L.-A., Kurosaki, T., Swat, W. and Veillette, A.
The SAP adaptor controls NK cell activation by regulating the enzymes Vav-1 and SHIP-1 and by enhancing conjugates with target cells.
Immunity, 2012 June; 36(6): 974-85

Guimont-Desrochers, F., Boucher, G., Dong, Z., Dupuis, M., Veillette, A. and Lesage, S.
Redefining interferon-producing killer dendritic cells as a novel intermediate in NK cell differentiation.
Blood, 2012 May; 119(19): 4349-57.

Zhong, M.-C. and Veillette A.
Csk keeps LYP on a leash.
Nature Chemical Biology, 2012 Apr 17; 8(5): 412-13.

Rhee, I. and Veillette A.
Protein tyrosine phosphatases in lymphocyte activation and autoimmunity.
Nature Immunology; 2012 Apr; 13(5): 439-47.

Wu, N. and Veillette A.
Immunology: Magnesium in a signaling role.
Nature, 2011 July; 475(7357): 471-6.

Dong, Z. and Veillette, A.
How do SAP family deficiencies compromise immunity?
Trends in Immunology, 2010 Aug; 31(8): 295-302.

Davidson, D., Shi, X. Zhong, M.-C., Rhee I., Veillette, A.
The phosphatase PTP-PEST promotes secondary T cell responses by dephosphorylating the protein  tyrosine kinase Pyk2.
Immunity, 2010 Aug; 33: 1-14.

Cruz-Munoz, M.E. and Veillette, A.
Do NK cells always need a license to kill?
Nat Immunol, News and Views; 2010 Apr; 11 (4): 279-80.

Veillette, A.
SLAM  family receptors: immune regulators with or without SAP family adaptors.
Cold Spring Harb Perspect Biol, 2010 Mar; 2 (3): a002469.

Dong, Z., Cruz-Munoz, M.-E., Zhong, M.-C., Chen, R., Latour, S., Veillette, A.
Essential function for SAP family adaptors in the surveillance of hematopoietic cells
by natural killer cells.
Nature Immunol, 2009; 10: 973-980.

Veillette, A.
Organization of immunoreceptor signaling by adapters.
Immunol Rev, 2009; 232: 5-6.

Veillette, A., Dong, Z., Pérez-Quintero, L.-A., Zhong, M.-C., Cruz-Munoz, M.-E.
Importance and mechanism of `switch`function of SAP family adapters.
Immunol Rev, 2009; 232: 229-239.

Veillette, A., Rhee, I., Martins Souza, C., Davidson, D.
PEST family phosphatases in immunity, autoimmunity, and autoinflammatory disorders.
Immunol Rev, 2009; 228: 312-324.

Cruz-Munoz, M.E., Dong, Z., Shi, X., Zhang, S., Veillette, A.
Influence of CRACC, a SLAM family receptor coupled to the adaptor EAT-2, on natural
killer cell function.
Nat Immunol, 2009 Mar; 10 (3): 297-305.

 

 I RECENT PUBLICATIONS 

Veillette, A., Zhang, S., Shi, X., Dong, Z., Davidson, D., and Zhong, M.-C.
SAP expression in T cells, not in B cells, is required for humoral immunity.
Proc. Natl. Acad. Sci. USA 2008; 105:1273-1278.

Veillette, A., Dong, Z., and Latour, S.
Consequence of the SLAM-SAP signaling pathway in innate-like and conventional
lymphocytes.
Immunity 2007; 27: 698-710.

Davidson, D., Schraven, B. and Veillette, A.
PAG-associated FynT regulates calcium signaling and promotes anergy in T lymphocytes.
Mol. Cell. Biol. 2007; 27:1960-1973.

Chen, R., Latour, S., Shi, X. and Veillette, A.
Association between SAP and FynT: inducible SH3 domain-mediated interaction controlled
by engagement of the SLAM receptor.
Mol. Cell. Biol. 2006; 26: 5559-5568.

Veillette, A.
Immune regulation by SLAM family receptors and SAP-related adaptors.
Nat. Rev. Immunol. 2006; 6:56-66.

Roncagalli, R., Taylor, J.E.R., Zhang, S., Shi, X., Chen, R., Cruz-Munoz, M.E., Yin, L., Latour, S., and Veillette, A.
Negative regulation of NK cell functions by EAT-2, a SAP-related adaptor.
Nat Immunol 2005; 6L1002-1010.

Davidson, D., Shi X., Zhang, S. Wang, H., Nemer, M., Ono, N., Ohno, S., Yanagi, Y and Veillette A.
Genetic evidence linking SAP, the X-linked lymphoproliferative gene product, to Src-related kinase FynT in TH2 cytokine regulation.
Immunity 2004;21:707-717.

Chen, R., Relouzat, F., Roncagalli, R., Aoukaty, Al, Tan, R., Latour, S. and Veillette, A.
Molecular dissection of 2B4 signalling: implications for signal transduction by SLAM-related receptors.
Mol. Cell. Biol. 2004; 24:5144-5156.

Davidson, D., Bakinowski, M., Thomas, M.L., Horejsi, V. and Veillette, A.
Phosphorylation-dependent regulation of T-cell activation by PAG/Cbp, a lipid raft-associated transmembrane adaptor.
Mol. Cell. Biol. 2003;23:2017-2028.

Latour, S., Roncagalli, R., Chen, R., Bakinowski, M., Shi, X., Schwartzberg, P.L., Davidson, D. and Veillette, A.
Binding of SAP SH2 domain to FynT SH3 domain reveals a novel mechanism of receptor signalling in immune regulation.
Nat. Cell. Biol. 2003;5:149-154.

Veillette, A., Latour, S. and Davidson, D.
Negative regulation of immunoreceptor signalling.
Annu. Rev. Immunol. 2002;20:669-707.

Latour, S., Gish, G., Helgason, C.D., Humphries, R.K., Pawson, T. and Veillette, A.
Regulation of SLAM-mediated signal transduction by SAP, the X-linked lymphoproliferative gene product.
Nat. Immunol. 2001;2:681-690.

Davidson, D. and Veillette, A.
PTP-PEST, a scaffold protein tyrosine phosphatase, negatively regulates lymphocyte activation by targeting a unique set of substrates.
EMBO J. 2001;20:3414-3426.

Lemay, S., Davidson., D., Latour, S. and Veillette, A.
Dok-3, a novel adapter molecule involved in the negative regulation of immunoreceptor signaling.
Mol. Cell. Biol. 2000;20:2743-2754.

Cao, M.Y., Davidson, D., Yu, J., Latour, S. and Veillette, A.
Clnk, a novel SLP-76-related adaptor molecule expressed in cytokine-stimulated hemopoietic cells.
J. Exp. Med. 1999;190:1527-1534.

Cloutier, J.-F. and Veillette, A.
Cooperative inhibition of T-cell antigen receptor signaling by a complex between a kinase and a phosphatase.
J. Exp. Med. 1999;189:111-121.

Latour, S., Zhang, J., Siraganian, R.P. and Veillette, A.
A unique insert in the linker domain of Syk is necessary for its function in immunoreceptor signalling.
EMBO J. 1998;17:2584-2595.

Latour, S., Fournel, M. and Veillette, A.
Regulation of T-cell antigen receptor signalling by Syk tyrosine protein kinase.
Mol. Cell. Biol. 1997;17:4434-4441.

Cloutier, J.-F. and Veillette, A.
Association of inhibitory tyrosine protein kinase p50csk with protein tyrosine phosphatase PEP in T cells and other hemopoietic cells.
EMBO J. 1996;15:4909-4918.

Fournel, M., Davidson, D., Weil, R. and Veillette, A.
Association of tyrosine protein kinase Zap-70 with the protooncogene product p120c-cbl in T lymphocytes.
J. Exp. Med. 1996;183:301-306.

Davidson, D., Viallet, J. and Veillette, A.
Unique catalytic properties dictate the enhanced function of p59fynT, the hemopoietic cell-specific isoform of the Fyn tyrosine protein kinase, in T cells.
Mol. Cell. Biol. 1994;14:4554-4564.

Chow, L.M.L., Fournel, M., Davidson, D. and Veillette, A.
Negative regulation of T-cell receptor signalling by tyrosine protein kinase p50csk.
Nature 1993;365:156-160.

Davidson, D., Chow, L.M.L., Fournel, M. and Veillette, A.
Differential regulation of T cell antigen responsiveness by isoforms of the src-related tyrosine protein kinase p59fyn.
J. Exp. Med. 1992;175:1483-1492.

Abraham, N., Miceli, M.C., Parnes, J.R. and Veillette, A.
Enhancement of T-cell responsiveness by the lymphocyte-specific tyrosine protein kinase p56lck.
Nature 1991;350:62-66.

Veillette, A., Zuniga-Pflücker, J.C., Bolen, J.B. and Kruisbeek, A.M.
Engagement of CD4 and CD8 expressed on immature thymocytes induces activation of intracellular tyrosine phosphorylation pathways.
J. Exp. Med. 1989;170:1671-1680.

Veillette, A., Bookman, M.A., Horak, E.M., Samelson, L.E. and Bolen, J.B.
Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck.
Nature 1989;338:257-259.

Veillette, A., Bookman, M.A., Horak, E.M. and Bolen, J.B.
The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck.
Cell 1988;55:301-308.

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