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Research unit director

Research papers

  Couturier A, Fleury H; Patenaude A-M; Bentley V; Rodrigue A; Coulombe Y; Joshi N; Pauty N; Berman J, Dellaire G; Di Noia, JM, Mes-Masson A-M, Masson J-Y. Roles for APRIN (PDS5B) in homologous recombination and in ovarian cancer prediction. Nucl. Acids Res. 2016, 44(22):10879-10897. .

 Cortizas E*, Zahn A*, Shiva S*, Reed JA, Vega F, Di Noia JM#, Verdun RE#. UNG protects B cells from AID-induced telomere loss. J. Exp. Med. 2016, 213(11), 2459-2472. .

 Litzler LC, Methot SP, Patenaude AM, Zahn A, Di Noia JM#. Cell-based Assays to Monitor AID Activity. Bioprotocol 2016; 6(3): e1724. .

SPAN>Litzler LC, Methot SP, Patenaude AM, Zahn A, Di Noia JM#. Cell-based Assays to Monitor AID Activity. Bioprotocol 2016; 6(3): e1724. />

Montamat-Sicotte D, Litzler LC, Abreu C, Safavi S, Zahn A, Orthwein A, Müschen M, Oppezzo P, Muñoz DP, Di Noia JM#. HSP90 inhibitors decrease AID levels and activity in mice and in human cells. Eur J Immunol. 2015, 45:2365-76. .

Methot SP, Litzler LC, Trajtenberg F, Zahn, A, Robert F, Pelletier J, Buschiazzo A, Magor BG, Di Noia JM#. Consecutive interactions with HSP90 and eEF1A1 underlie a functional maturation and storage pathway of AID in the cytoplasm. J. Exp. Med. 2015, 212:581-596. .

Collin R, Dugas V, Chabot-Roy G, Salem D, Zahn A, Di Noia JM, Rauch J, Lesage S. Autoimmunity and antibody affinity maturation are modulated by genetic variants on mouse chromosome 12. J Autoimmun. 2015, 58:90-9. .

Zahn A, Eranki AK, Patenaude AM, Methot SP, Fifield H, Cortizas EM, Foster P, Imai K, Durandy A, Larijani M, Verdun RE, Di Noia JM. Activation induced deaminase C-terminal domain links DNA breaks to end protection and repair during class switch recombination. Proc Natl Acad Sci U S A. 2014, 111(11):E988-E997.

Yu H, Pak H, Hammond-Martel I, Ghram M, Rodrigue A, Daou S, Barbour H, Corbeil L, Hébert J, Drobetsky E, Masson JY, Di Noia JM, and Affar EA. Tumor suppressor and deubiquitinase BAP1 promotes DNA double-strand break repair. Proc Natl Acad Sci. 2014, 111:285-90.

Cortizas EC, Zahn A, Hajjar ME, Patenaude AM, Di Noia JM. Verdun RE. Alternative End Joining and Classical-NHEJ Pathways Repair Different Types of Double Strand Breaks During Class Switch Recombination. J immunol. 2013;191:5751-63.

Muñoz DP, Lee EL, Takayama S, Coppé JP, Heo SK, Boffelli D, Di Noia JM, Martin DIK. Activation-induced cytidine deaminase (AID) is necessary for the epithelial-mesenchymal transition in mammary epithelial cells. Proc Natl Acad Sci. 2013; 110(32):E2977-86.

Zahn A, Daugan M, Safavi S, Godin D, Cheong C, Lamarre A, Di Noia JM. Separation of function between isotope switching and affinity maturation in vivo and circulating autoantibodies in UNG-deficient mice. J immunol.

Campo VA, Patenaude AM, Kaden S, Horb L, Firka D,Jiricny J and Di Noia JM. MSH6- or PMS2-deficiency causes re-replication in DT40 B cells, but it has little effect on immunoglobulin gene conversion or on repair of AID-generated uracils. Nucl. Acids Res. 2013 doi: 10.1093/nar/gks1470 [open access].

Hu Y, Ericsson I, Torseth K, Methot SP, Sundheim O, Liabakk NB, Slupphaug G, Di Noia JM, Krokan HE, Kavli B. A Combined Nuclear and Nucleolar Localization Motif in Activation-Induced Cytidine Deaminase (AID) Controls Immunoglobulin Class Switching. J Mol Biol.  2013; 425:424-43. doi: 10.1016/j.jmb.2012.11.026. Epub 2012 Nov 23.

Orthwein A, Zahn A, Methot S, Godin D, Conticello SG, Terada K and Di Noia JM. Optimal functional levels of Activation Induced Deaminase specifically require the Hsp40 DnaJa1. EMBO J 2011; 31: 679-91.

De Marchi, CR; Di Noia, JM; Frasch, AC; Amato Neto, V; Almeida, IC; Buscaglia, CA. Evaluation of a Recombinant Trypanosoma cruzi Mucin-Like Antigen for Serodiagnosis of Chagas' Disease. Clin. Vaccine Immunol 2011; 18:1850-5.

Orthwein A, Patenaude A-M, Affar E-B, Lamarre A, Young JC and Di Noia, JM. Regulation of Activation Induced Deaminase stability and antibody gene diversification by Hsp90. J Exp Med 2010; 207:2751-2765.

Patenaude A-M, Orthwein, A, Yi Hu, Campo, VA, Kavli, B, Buschiazzo, A and Di Noia, JM. Nuclear import and cytoplasmic retention of Activation Induced Deaminase. Nat Struct Mol Biol 2009; 16:517-27.



Casellas R#, Basu U, Yewdell WT, Chaudhuri J, Robbiani DF, Di Noia JM#. Mutations, kataegis, and translocations in B lymphocytes: towards a mechanistic understanding of AID promiscuous activity. Nat Rev Immunol. 2016; 16:164-76.

  Methot SP and Di Noia JM#. Pharmacological manipulation of AID. Oncortarget 2015; 6:26550-26551.

  Di Noia JM#. Molecular biology: Unequal opportunity during class switching. Nature 2015; 525:44–45.

  Montamat-Sicotte D, Palacios F, Di Noia JM# and Oppezzo P#. Origins and consequences of AID expression in lymphoid neoplasms. Current Immunology Reviews, 2013; 9(2):75-85.

  Orthwein, A and Di Noia, JM. AID: How much and where?.Semin Immunol, 2012; 24:246-254.

Orthwein, A and Di Noia, JM. Moduler la diversification des anticorps pour combattre certaines maladies. Médecine Sciences Amérique; 1(2), April 15th, 2012 (online journal in French).

Patenaude A-M and Di Noia, JM. The mechanisms regulating the subcellular localization of AID. Nucleus. 2010; 1(4):325-331.

Di Noia JM, Neuberger MS. Molecular mechanisms of antibody somatic hypermutation. Ann Rev Biochem, 2007; 76:1-22.

Montamat-Sicotte D, Palacios F, Di Noia JM# and Oppezzo P#. Origins and consequences of AID expression in lymphoid neoplasms. Current Immunology Reviews, 2013; 9(2):75-85.


Book chapters

 Methot P and Di Noia JM#. Molecular mechanisms of somatic hypermutation and class switch recombination. Adv Immunol, 133:37-87, 2017.

 Zahn A and Di Noia JM#. AID in Somatic Hypermutation and Class Switch Recombination. In: Ratcliffe, M.J.H. (Editor in Chief), Encyclopedia of Immunobiology, Vol. 2, pp. 115–125. Oxford: Academic Press, 2016.

 Ramiro, A and Di Noia, JM. Regulatory mechanisms of AID function. In: DNA Deamination and the Immune System. S Fungmann, M Diaz & FN Papavasiliou Eds. Imperial College Press, London, UK. 2010. in press.

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