Dr. Cheolho Cheong’s laboratory at the IRCM researches the biology of dendritic cells, with a special focus on host-pathogen interactions (non-sterile) and sterile inflammation (atherosclerosis, autoimmunity and cancer) mediated by monocyte-derived DCs (moDCs).
MoDCs are now starting to be recognized in the immunology field after Dr. Cheong’s discovery (Cell 2010). In addition, he has acquired essential methodologies of modern DC biology and has become familiar with many immunological assays. The proposed study in his research plan, generating genetic tools for MoDCs, will be widely used in the field.
Moreover, in contrast to mouse DC biology, which has mainly focused on lymphoid and non-lymphoid tissue DCs, human DC biology, with easy access to blood monocytes, has been mainly explored in the context of MoDCs in vitro. Dr. Cheong will pursue MoDC biology of human and SCID-hu mouse (BLT) model in vivo. As he is now starting to uncover the in vivo pathway of MoDC generation in mice, Dr. Cheong believes that understanding MoDCs in mice will shed light on the human MoDCs, and will allow him, and the scientific community, to assess their clinical importance in infection, inflammation, autoimmunity, and cancer.