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Research unit director

 We deeply regret to inform you of the passing of Cheolho Cheong, on April 24, 2016. For more information, please refer to the death notice.

  1. Cybulsky MI, Cheong C, and Robbins CS. Macrophages and Dendritic Cells-Partners in Atherogenesis. Circulation Research118:637-652 (2016)

  2. Yun TJ, Lee JS, Machmach K, Shim D, Choi J, Wi YJ, Jang HS, Jung IH, Kim K, Yoon WK, Miah MA, Li B,  Chang J, Bego MG, Pham TNQ, Loschko J, Fritz JH, Krug AB, Lee SP, Keler T, Guimond JV, Haddad E, Cohen EA, Sirois MG, El-Hamamsy I, Colonna M, Oh GT, Choi JH, and Cheong C. Indoleamine 2,3-Dioxygenase-Expressing Aortic Plasmacytoid Dendritic Cells Protect Atherosclerosis Through Induction of Regulatory T Cells. Cell Metabolism. 23: 852-866 (2016)

  3. Yun TJ, Lee JS, Shim D, Choi JH and Cheong C. Isolation and Characterization of Aortic Dendritic Cells and Lymphocytes in Atherosclerosis. Methods in Molecular Biology. In Press (2015)

  4. Hernandez-Anzaldo S, Berry E, Brglez V, Leung D, Yun TJ, Lee JS, Filep JG, Kassiri Z, Cheong C, Lambeau G, Lehner R, Fernandez-Patron C.Identification of a Novel Heart-Liver Axis: Matrix Metalloproteinase-2 Negatively Regulates Cardiac Secreted Phospholipase A2 to Modulate Lipid Metabolism and Inflammation in the Liver. J Am Heart Assoc. 2015 Nov 13;4(11) pii: e002553. doi: 10.1161/JAHA.115.002553

  5. Ensan S, Li A, Besla R, Degousee N, Cosme J, Roufaiel M, Shikatani EA, El-Maklizi M, Williams JW, Robins L, Li C, Lewis B, Yun TJ, Lee JS, Wieghofer P, Khattar R, Farrokhi K, Byrne J, Ouzounian M, Zavitz CC, Levy GA, Bauer CM, Libby P, Husain M, Swirski FK, Cheong C, Prinz M, Hilgendorf I, Randolph GJ, Epelman S, Gramolini AO, Cybulsky MI, Rubin BB, Robbins CS.Self-renewing resident arterial macrophages arise from embryonic CX3CR1+ precursors and circulating monocytes immediately after birth. Nat Immunol. 17(2):159-168 (2015)

  6. Conde P, Rodriguez M, van der Touw W, Jimenez A, Burns M, Miller J, Brahmachary M, Chen HM, Boros P, Rausell-Palamos F, Yun TJ, Riquelme P, Rastrojo A, Aguado B, Stein-Streilein J, Tanaka M, Zhou L, Zhang J, Lowary TL, Ginhoux F, Park CG, Cheong C, Brody J, Turley SJ, Lira SA, Bronte V, Gordon S, Heeger PS, Merad M, Hutchinson J, Chen SH, Ochando J. DC-SIGN(+) Macrophages Control the Induction of Transplantation Tolerance. Immunity. 42(6):1143-58 (2015)

  7. Yang K, Park CG, Cheong C, Bulgheresi S, Zhang S, Zhang P, He Y, Jiang L, Huang H, Ding H, Wu Y, Wang S, Zhang L, Li A, Xia L, Bartra SS, Plano GV, Skurnik M, Klena JD, Chen T. Host Langerin (CD207) is a receptor for Yersinia pestis phagocytosis and promotes dissemination. Immunol Cell Biol. 93(9):815-24 (2015)

  8. Lee H, Ruane D, Law K, Ho Y, Garg A, Rahman A, Esterházy D, Cheong C, Goljo E, Sikora AG, Mucida D, Chen BK, Govindraj S, Breton G, Mehandru S. Phenotype and funciton of nasal dendritic cells. Mucosal Immunology. 2015 Feb 11. doi: 10.1038/mi.2014.135. [Epub ahead of print]

  9. Sinnathamby T, Yun TJ, Clavet-Lanthier ME, Cheong C, Sirois MG. VEGF and angiopoietins promote inflammatory cell recruitment and mature blood vessel formation in murine sponge/Matrigel model. J. Cell. Biochem. 16:45-57 (2015)

  10. Anandasabapathy N, Feder R, Mollah S, Tse S, Longhi MP, Mehandru S, Matos I, Cheong C, Ruane D, Brane L, Teixeria A, Dobrin J, Mizenina O, Park C, Meredith M, Clausen B, Nussenzweig M, and Steinman RM. Classcial Flt3L-dependent dendritic cells control immunity to protein vaccine. J. Exp. Med. 211:1875-91 (2014) 

  11. Roh J*, Cheong C*, Sung YH, Lee J, Oh J, Lee BS, Lee J, Gho YS, Kim DK, Park CB, Lee JH, Lee JW, Kang SM, and Lee HW. Pertubation of NCOA 6 leads to dilated cardiomyopathy. Cell Reports. 8:991-8 (2014)  *Co-First Author

  12. Chapuy L, Bsat M, Mehta H, Rubio M, Wakahara K, Van WQ, Baba N, Cheong C, Yun TJ, Panzini B, Wassef R, Richard C, Tamaz R, Soucy G, Delespesse G and Sarfati M.  Basophils increase in Crohn disease and ulcerative colitis and favor mesenteric lymph node memory TH17/TH1 response. J. Allergy Clin. Immunol. 134:978-81 (2014)

  13. Ponichtera HE, Shainheit MG, Liu BC, Raychowdhury R, Larkin BL, Russo JM,  D. Salantes B, Lai C, Parnell LD, Yun TJ, Cheong C,  Bunnell SC, Hacohen N and Stadecker MJ. CD209a expression on dendritic cells is critical for the development of pathogenic Th17 cell responses in murine schistosomiasis. J. Immunol. 192:4655-65 (2014)

  14. Rhee I, Zhong MC, Reizis B, Cheong C and Veillette A. Control of dendritic cell migration, T cell-dependent immunity and autoimmunity by protein tyrosine phosphatase PTPN12 expressed in dendritic cells. Mol. Cell. Biol. 34:888-99 (2014)

  15. Mollah S, Dobrin J, Feder R, Tse SW, Matos I, Cheong C, Steinman RM, Anandasabapathy N. Flt3L-Dependence Helps Define an Uncharacterized Subset of Murine Cutaneous Dendritic Cells. J. Invest. Dermatol. 134:1265-75(2014)

  16. Ruane D , Brane L , Reis B, Cheong C, Poles J , Do Y , Zhu H , Velinzon K , Choi JH , Studt N , Mayer L , Lavelle E , Steinman R , Mucida D, and Mehandru S. Lung dendritic cells induce migration of protective T cells to the gastrointestinal tract. J. Exp. Med. 210:1871-88 (2013)

  17. Wohn C, Ober-Blobaum J, Haak S, Pantelyushin S, Cheong C, Zahner SP, Onderwater S, Kant M, Weighardt H, Holzmann B, Reizis B, Becher B, Prens B and Clausen BE. Langerinneg conventional DC-derived IL-23 drives psoriatic plaque formation in mice. PNAS. 110:10723-8 (2013)

  18. Zahn A , Daugan M, Safavi S,  Godin D, Cheong C, Lamarre A and Di Noia JM. Separation of function between isotype switching and affinity maturation in vivo and circulating autoantibodies in UNG-deficient mice, J. Immunol. 190:5949-60 (2013)

  19. Leung CS, Maurer MA, Meixlsperger S, Lippmann A, Cheong C, Zuo J, Haigh TA, Taylor GS, Münz C. Robust T cell stimulation by Epstein-Barr virus-transformed B cells after antigen targeting to DEC-205. Blood. 121:1584-94 (2013)

  20. Prabagar MG, Do Y, Ryu S, Park JY, Choi HJ, Choi WS, Yun TJ, Moon J, Choi IS, Ko K, Ko K, Shin CY, Cheong C and Kang YS. SIGN-R1, a C-type lectin, enhances apoptotic cell clearance through the complement deposition pathway by interacting with C1q in the spleen. Cell Death Differ. 20:535-45 (2013)

  21. Nakano H, Burgents JE, Nakano K, Whitehead GS, Cheong C, Bortner CD, and Cook DN. Migratory properties of pulmonary dendritic cells are determined by their developmental lineage. Mucosal Immunol. 6:678-91 (2013)

  22. Cheong C* and Choi JH. Dendritic cells and regulatory T cells in atherosclerosis. Mol. Cells. 34:341-7 (2012) *Corresponding author
  23. Meredith M, Liu K, Darrasse-Jeze G, Kamphorst AO, Schreiber H, Guermonprez P, Idoyaga J, Cheong C, Yao KH, Niec RE, Nussenzweig MC. Expression of the zinc finger transcription factor zDC (zbtb46, Btbd4) defines the classical dendritic cell lineage. J.Exp. Med. 209:1153-65 (2012)
  24. Pantel A, Cheong C, Dandamudi D, Shrestha E, Mehandru S, Brane L, Ruane D, Teixeira A, Bozzacco L, Steinman RM, and Longhi MP. A new synthetic TLR4 agonist, GLA, allows antigen targeted dendritic cells to elicit Th1 T-cell immunity in vivo. Eur. J. Immunol. 42:101-9 (2012)
  25. Choi JH*, Cheong C*, Dandamudi DB, Park CG, Rodriguez AM, Mehandru S, Velinzon K, Jung IH, Yoo J, Oh GT, Steinman RM. Flt3 signaling-dependent dendritic cells protects against atherosclerosis. Immunity 35: 819-831 (2011) *Co-first Author
  26. Cheong C*, Matos I, Choi JH, Dandamudi DB, Shrestha E, Longhi MP, Jeffrey KL, Anthony RM, Kluger C, Nchinda G, Koh H, Rodriguez A, Idoyaga J, Pack M, Velinzon K, Park CG, Steinman RM. Microbial stimulation fully differentiates monocytes to DC-SIGN/CD209+ dendritic cells from immune T cell areas. Cell 143:416-429 (2010) *Corresponding author
  27. Cheong C, Choi J-H, Vitale L, He Li-Z, Trumpfheller C, Bozzacco L, Do Y, Nchinda G, Park  SH, Dandamudi, DB, Shrestha E, Pack M, Lee H-W, Keler T, Steinman RM, Park CG. Improved cellular and humoral immune responses in vivo following targeting of HIV Gag to dendritic cells within human anti-human DEC205 monoclonal antibody. Blood 116:3828-3838 (2010)
  28. Cheong C, Matos I, Choi J-H, Schauer JD, Dandamudi DB, Shrestha E, Makeyeva JA, Li X, Li P, Steinman, RM, Park CG. New monoclonal anti-mouse DC-SIGN antibodies reactive with acetone-fixed cells. J. Immunol. Meth. 360:66-75 (2010)
  29. Do Y, Koh H, Park CG, Dudziak D, Seo P, Mehandru S, Choi JH, Cheong C, Park S, Perlin DS, Powell BS,  Steinman RM. Targeting of LcrV virulence protein from Yersinia pestis to dendritic cells protects mice against pneumonic plague. Eur. J. Immunol. 40:2791-2796 (2010)
  30. Lee H, Green DJ, Lai L, Hou YJ, Jensenius JC, Liu D, Cheong C, Park CG, Zhang M. Early complement factors in the local tissue immunocomplex generated during intestinal ischemia/reperfusion injury. Mol. Immunol. 47:972-981 (2010)
  31. Choi J-H, Do Y, Cheong C, Koh H, Boscardin SB, Oh Y-S, Bozzacco L, Trumpfheller C, Park CG, Steinman RM. Identification of antigen presenting dendritic cells in mouse aorta and cardiac valves. J. Exp. Med. 206:497-505 (2009) PMC 2699134
  32. Park JY, Choi HJ, Prabagar MG, Choi WS, Kim SJ, Cheong C, Park CG, Chin CY, Kang YS. The C-type lectin CD209b is expressed on microglia and it mediates the uptake of capsular polysaccharides of Streptococcus pneumoniae. Neurosci. Lett. 450:246-251 (2009)
  33. Lee J*, Sung Y*, Cheong C*, Choi Y, Jeon H, Sun W, Kim H, Hahn WC, Lee H-W. TERT Promotes Cellular and Organismal Survival Independently of Reverse Transcriptase Activity. Oncogene 27:3754-3760 (2008) *Co-first author
  34. Idoyaga J*, Cheong C*, Suda K, Suda N, Kim JY, Lee H, Park CG, Steinman RM. Langerin/CD207 receptor on dendritic cells mediates efficient antigen presentation on MHC I and II products in vivo. J. Immunol. 180:3647-3650 (2008) *Co-first author.
  35. Park SH, Cheong C, Idoyaga J, Kim JY, Choi J-H, Do Y, Lee H, Jo JH, Oh Y-S, Im W, Steinman RM, Park CG. Generation and application of new rat monoclonal antibodies against synthetic FLAG and OLLAS tags for improved immunodetection. J. Immunol. Methods 331:27-28 (2008)
  36. Cheong C, Idoyaga J, Do Y, Pack M, Park SH, Lee H, Kang Y-S, Choi J-H, Kim JY, Bonito A, Inaba K, Yamazaki S, Steinman RM, Park CG. Production of monoclonal antibodies that recognize the extracellular domain of mouse Langerin/CD207. J. Immunol. Methods. 324:48-62 (2007)
  37. Dudziak D, Kamphorst AO, Heidkamp GF, Buchholz VR, Trumpfheller C, Yamazaki S, Cheong C, Liu K, Lee H-W, Park CG, Steinman RM, Nussenzweig MC. Differential antigen processing by dendritic cell subsets in vivo. Science 315:107-111 (2007)
  38. Kang Y-S, Do Y, Lee H-K, Park SH, Cheong C, Lynch RM, Loeffler JM, Steinman RM, Park CG. A dominant complement fixation pathway for pneumococcal polysaccharides initiated by SIGN-R1 interacting with C1q. Cell 125:47-58 (2006)
  39. Cheong C, Sung YH, Lee J, Choi YS, Song J, Kee C, Lee H-W. Role of INK4a in locus in normal eye development and cataract genesis. Mech. Aging Dev. 127: 633-638 (2006)
  40. Sung YH, Choi YS, Cheong C, Lee H-W. The Pleiotrophy of telomerase in mediating cell death. Mol. Cells 19:1164-1169 (2005)
  41. Choi YS, Lee JE, Sung YH, Yang EY, Park CB, Cheong C, Song J, Lee H-W. Generation of conditional and reversible Rb knockdown mice. Mech. Aging Dev. 126:1164-1169 (2005)
  42. Chung HK*, Cheong C*, Song J, Lee H-W. Extratelomeric functions of telomerase. Curr. Molec. Med. 5:233-241 (2005) *Co-first author
  43. Tanemura K, Ogura A, Cheong C, Gotoh H, Matsumoto K, Sato E, Hayashi Y, Lee H-W, Kondo T. Dynamic rearrangement of telomeres during spermatogenesis in mice. Develop. Biol. 281:196-207 (2005)
  44. Sung Y H, Sung J, Park B, Choi J, Kim J, Cheong C, Choi JS, Yang EY, Lee M, Han JS, Park SC, Han T-H, Kim TJ, Song K, Rhee H-W. Lee. Hematopoietic malignancies associated with increased Stat5 and Bcl-xL Expression in Ink4a/Arf-deficient mice. Mech. Aging Dev. 126:732-739 (2005)
  45. Cheong C, Hong KU, Lee HW. Mouse models for telomere and telomerase biology. Exp. Mol. Med. 35: 141-153 (2003)
  46. Kim TY, Lee KH, Chang S, Cheong C, Lee HW, Yim J, Kim TK. Oncogenic potential of a dominant negative mutant of interferon regulatory factor 3. J. Biol. Chem. 278:15272-15278 (2003)
  47. Lee S-H, Kim J, Lee H-W, Cho Y-S, Oh S-H, Cheong C, Zhang W, Lee J H. Interferon regulatory factor-1 (IRF-1) is a mediator for interferon- induced attenuation of telomerase activity and human telomerase reverse transcriptase (hTERT) expression. Oncogene 22:381-391 (2002)
  48. Kim S-W*, Cheong C*, Sohn Y-C, Goo Y-H, Oh WJ, Park JH, Joe SY, Kang H-S, Kim D-K, Kee C, Lee JW,  Lee H-W. Multiple developmental defects derived from impaired recruitment of ASC-2 to nuclear receptors in mice: Implication for posterior lenticonus with cataract. Mol. Cell. Biol. 22:8409-8414 (2002) *Co-first author.
  49. Cheong C, Lee H-W. Telomerase: Unraveling our ends. The biochemical society of the republic of Korea. Biochem. News 21:194-198 (2001)
  50. Lee H-W, Cheong C. Conditional gene targeting. Mol. Biol. News, the Korean Society of Molecular Biology. 11:16-19 (1999)
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