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Experimental Cardiovascular Biology
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Research unit director
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To identify cardiovascular risk factors, we have performed studies that use genetic crosses of inbred mouse strains. By integrating information about tissue gene expression profiles and the genetic maps of animals, we are attempting to elucidate which genes or groups of genes are responsible for certain cardiac phenotypic traits.

In addition to several autosomal loci, we have found that chromosome Y genetic variants could also shape certain characteristics of the heart, mostly by regulating the effects of androgens on the expression of certain genes. These phenomena appear to derive from the fact that certain chromosome Y genes do program the responses of autosomal genes to androgens. We are currently attempting to understand the chromatin remodeling mechanisms via which these chromosome Y genes can exert such effects.

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