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Molecular Biochemistry of Hypertension
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Research unit director
Director

Timothy L. Reudelhuber, PhD

  • Director, Molecular Biochemistry of Hypertension research unit
  • Full IRCM Research Professor
  • Executive Director, Academic Affairs
  • Full research professor, Department of Medicine (accreditation in biochemistry), Université de Montréal
  • Adjunct Professor, Department of Medicine (Division of Experimental Medicine), McGill University

The research focus of the molecular biochemistry of hypertension laboratory is the molecular mechanisms that are responsible for arterial hypertension. Specifically, the team is studying the renin-angiotension system and the molecular determinants of renin activity. The protein renin plays a crucial role in regulating arterial tension, making it a top choice for treating hypertension. Renin converts angiotensin into angiotensin l, which in turn is converted into angiotensin ll, a potent vasoconstrictor that stimulates the production of aldosterone, a steroid that affects arterial tension.

Degrees and relevant experience
Timothy L. Reudelhuber earned his B.Sc. in chemistry from the University of Texas (Arlington) and his PhD in biochemistry from the University of Texas Health Sciences Center Southwestern Medical School in Dallas. After a postdoctoral fellowship under the direction of Professor Pierre Chambon in Strasbourg, France, he joined the University of California in San Francisco as associate professor of biochemistry in medicine. In 1990, he joined the IRCM, where he heads the molecular biochemistry of hypertension research unit. His work has earned him many honours and awards, including the Merck-Frosst Chair in Molecular and Clinical Pharmacology, an MRC university-industry chair, and young investigator awards from the Canadian Hypertension Society and the American Society of Hypertension. He is associate director of the CIHR’s Multidisciplinary Research Group on Hypertension and a fellow of the American Heart Association.

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