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Molecular Biochemistry of Hypertension
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Research unit director

Selected publication

Lochard, N., Thibault, G., Silversides, D.W., Touyz, R.M. and Reudelhuber, T.L. Chronic production of angiotensin IV in the brain leads to hypertension that is reversible with an angiotensin II AT1 receptor antagonist. Circ. Res. 94:1451-1457 (2004)

Amiri, F., Virdis, A., Neves, M.F., Iglarz, M., Seidah, N.G., Touyz, R.M., Reudelhuber, T.L., Schiffrin, E.L. Endothelium-restricted overexpression of human endothelin-1 causes vascular remodeling and endothelial dysfunction. Circulation 110:2233-2240 (2004)

Reudelhuber, T.L. The renin-angiotensin system: peptides and enzymes beyond angiotensin II. Curr Opin Nephrol Hypertens. 14:155-159 (2005)

Lacombe, M.-J., Mercure, C., Dikeakos, J.D., Reudelhuber, T.L. Modulation of secretory granule targeting efficiency by Cis and Trans compounding of sorting signals. J. Biol. Chem. 280:4803-4807 (2005)

Touyz, R.M., Mercure, C., He, Y., Javeshghani, D., Yao, G., Callera, G., Yogi, A., Lochard, N., Reudelhuber, T.L. Angiotensin II-dependent chronic hypertension and cardiac hypertrophy are unaffected by gp91phox-containing NADPH oxidase. Hypertension 45:530-537 (2005)

Dikeakos, J.D., Lacombe, M.-J., Mercure, C., Mireuta, M., Reudelhuber, T.L. A hydrophobic patch in a charged alpha-helix is sufficient to target proteins to dense core secretory granules. J Biol Chem  282:1136-43 (2007).

Dikeakos, J.D., Mercure, C., Lacombe, M.J., Seidah, N.G., Reudelhuber, T.L. PC1/3, PC2 and PC5/6A are targeted to dense core secretory granules by a common mechanism. FEBS J 274:4094-4102 (2007).

Reudelhuber, T.L., Bernstein, K.E., Delafontaine, P. Is angiotensin II a direct mediator of left ventricular hypertrophy? Time for another look. Hypertension 49:1196-1201 (2007).

Dikeakos, J.D., and Reudelhuber, T.L. Sending proteins to dense core secretory granules: still a lot to sort out. J. Cell Biol 177:191-196 (2007).

Mercure, C., Yogi, A.,  Aranha, A.B., Bader, M., Ferreira, A.J., Santos, R.A.S., Walther, T., Touyz, R.M., and Reudelhuber, T.L. Angiotensin 1-7 blunts hypertensive cardiac remodeling by a direct effect on the heart. Circulation Research 103:1319-1326 (2008).

Dikeakos, J., Di Lello, P., Lacombe, M.-J. , Legault, P., Reudelhuber T.L., Omichinski, J. Functional Anatomy of a Secretory Granule Sorting Domain: Solution Structure of the C-terminal Helical Domain of the Protease PC1/3. Proc Natl Acad Sci USA 106:7408-7413 (2009).

Mercure, C., Prescott, G., Lacombe, M.-J., Silversides, D.W., and Reudelhuber, T.L. Chronic increases in circulating prorenin are not associated with renal or cardiac pathologies. Hypertension 53:1062-1069 (2009).

Wang, Y., Qian, C., Roks, A., Westermann, D., Schuhmacher, S.-M., Escher, F., Schoemaker, R., Reudelhuber, T.L., van Gilst, W., Schultheiss, H.-P., Tschöpe, C., and Walther, T. Circulating rather than cardiac angiotensin-(1-7) stimulates cardioprotection post myocardial infarction. Circ. Heart Failure 3:286-293. (2010).

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