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Research unit director
Publications

J. Eguchi, X. Wang, S. Yu, E. Kershaw, P.Chiu, J. Dushay, J.L. Estall, U. Klein, E. Maratos-Flier, and E. D. Rosen. Transcriptional control of adipose lipid handling by IRF4.  Cell Metab. 2011 Mar 2;13(3):249-59.

Wu J, Ruas JL, Estall J.L., Rasbach KA, Choi JH, Ye L, Boström P, Tyra HM, Crawford RW, Campbell KP, Rutkowski DT, Kaufman RJ, Spiegelman BM. The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1α /ATF6α complex. Cell Metab. Feb 2;13(2):160-9, 2011.

Seale, P., Conroe, H.M., Estall, J., Kajimura, S., Frontini, A., Ishibashi, J., Cohen, P., Cinti, S. and Bruce M. Spiegelman. Prdm16 determines the thermogenic program of subcutaneous white adipose tissue. J Clin Invest. Jan 4;121(1):96-105, 2011.

Rasbach, K.A., Gupta, R.K., Ruas, J.L., Wu, J., Naseri, E., Estall, J.L., and Bruce M. Spiegelman. PGC-1α regulates a HIF2α-dependent skeletal muscle fiber type switch. Proc Natl Acad Sci. Nov 24, 2010.

Choi J.H., Banks A.S.*, Estall J.L.*, Kajimura S.*, Böstrom P., Laznik D., Chalmers M.J., Kamenecka T.M., Bluher M., Griffin P.R., and Spiegelman B.M. Obesity-linked phosphorylation of PPARγ by cdk5 is a direct target of the anti-diabetic PPARγ ligands. Nature. Jul 22;466(7305):451-6, 2010. * denotes equal contribution

Estall J.L., Ruas J.L., Choi C., Laznik D., Badman M., Maratos-Flier E., Shulman G.I., and Spiegelman B.M.  PGC-1α negatively regulates hepatic FGF21 expression by modulating the heme/Rev-Erbα axis.
Proc Natl Acad Sci. Dec 29;106(52):22510-5, 2009.

Estall J.L., Kahn, M., Cooper, M.P., Fisher, F.M., Wu, M.K, Laznik, D, Qu, L, Cohen, D.E., Shulman, G.I., and Bruce M. Spiegelman.  Sensitivity of lipid metabolism and insulin signaling to genetic alterations in hepatic PGC-1α expression.  Diabetes. Jul;58(7):1499-508, 2009.

Yusta B, Baggio L.L,. Estall J.L., Koehler J.A., Holland D.P., Li H, Pipeleers D, Ling Z, Drucker D.J.  GLP-1 receptor activation improves beta cell function and survival following induction of endoplasmic reticulum stress.  Cell Metabolism. Nov;4(5):391-406, 2006.

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