Selected publications

Sairam, M.R., Dierich, A., Monaco, L., Fimia, G.M., Gansmuller, A., LeMeur, M., and Sassone-Corsi, P. Impairing follicle-stimulating hormone (FSH) signaling in vivo: Targeted disruption of the FSH receptor leads to aberrant gametogenesis and hormonal imbalance. Proc. Natl. Acad. Sci. (USA) 95: 13612-13617, 1998.

Babu, P.S., Jiang, L., Sairam, A.M., Touyz, R.M., and Sairam, M.R. Structural features and expression of an alternativelyspliced growth factor type I receptor for follitropin signaling in the developing ovary. Mol. Cell. Biol. Res. Commun. 2: 21-27, 1999.

Krishnamurthy, H., Kumar KM, P., Joshi, C.V., Krishnamurthy, H.N., Moudgal, R.N., and Sairam, M.R. Alterations in sperm characteristics of FSH-immunized men are similar to those of FSH-deprived infertile male bonnet monkeys. J. Androl. 21: 316-327, 2000.

Touyz, R.M., Jiang, L., and Sairam, M.R. Follicle-stimulating hormone mediated calcium signaling by the alternatively spliced growth factor type I receptor. Biol. Reprod. 62: 1067-1074, 2000.

Krishnamurthy, H., Danilovich, N., Morales, C.R., Sairam, M.R. Qualitative and quantitative decline in spermatogenesis of the follicle stimulating hormone receptor knockout (FORKO) mouse. Biol. Reprod. 62: 1146-1159, 2000.

Danilovich, N., Babu, P.S., Xing, W., Gerdes, M., Krishnamurthy, H., and Sairam, M.R. Estrogen deficiency, obesity, and skeletal abnormalities in follicle stimulating hormone receptor knockout (FORKO) female mice. Endocrinology 141: 4295-4308, 2000.

Babu, P.S., Krishnamurthy, H., Chedrese, P.J., and Sairam, M.R. Activation of extracellular-regulated kinase pathways in ovarian granulosa cells by the novel growth factor type I follicle-stimulating hormone receptor: role in hormone signaling and cell proliferation. J. Biol. Chem. 275: 27615-27626, 2000.

Babu, P.S., Danilovich, N., and Sairam, M.R. Hormone-Induced Receptor Gene-Splicing: Enhanced Expression of the Growth Factor Type I FSH Receptor Motif in the Developing Mouse Ovary as a New Paradigm in Growth Regulation. Endocrinology. 142: 381-389, 2001.

Xing, W. and Sairam, M.R. Characterization of regulatory elements of ovine FSH receptor gene: the role of E-box in the regulation of Ovine FSH receptor expression. Biol. Reprod. 64: 579-589, 2001.

Danilovich, N. Roy. I and Sairam, M.R. Ovarian pathology and high incidence of sex cord tumors in follitropin receptor knockout (FORKO) mice. Endocrinology, 142: 3673-3684, 2001.

Krishnamurthy, H., Babu, P.S., Morales, C.R., and Sairam, M.R. Delay in sexual maturity of the follicle-stimulating hormone receptor knockout (FORKO) male mouse. Biol. Reprod., 65, 522-531, 2001.

Krishnamurthy, H., Kats, R., Danilovich, N. and Sairam M.R. Intercellular communication between the Sertoli and Leydig cells in the absence of follicle-stimulating hormone. Biol. Reprod. 65, 1201-1207, 2001.

Xing, W. and Sairam, M.R. The role of CACC box in the regulation of ovine FSH receptor expression. Biol. Reprod. 65,1142-1147, 2001.

Moudgal, N.R., Krishnamurthy, H.N., Surekha, S., Krishnamurthy, H., Dhople, V.K., Nagaraj, R., and Sairam, M.R. Immunobiology of a synthetic luteinizing hormone receptor peptide 21-41. J. Androl. 22, 992-998, 2001.

Sairam, M.R. and Krishnamurthy, H. The role of follicle stimulating hormone in spermatogenesis: Lessons from knockout animal models. Arch. Med. Res. 32: 601-608, 2001.

Sairam, M.R., Danilovich, N., and Lussier-Cacan, S. The FORKO mouse as a genetic model for exploring estrogen replacement therapy. J. Reprod. Med. 47: 412-418, 2002.

Xing, W., Danilovich, N., and Sairam, M.R. Orphan receptors COUP-TF’s inhibit SF-1, USF and AP-1 activation of ovine FSH receptor expression via composite cis-elements. Biol. Reprod. 66: 1656-1666, 2002.

Xing, W. and Sairam, M.R. Retinoic acid mediates transcriptional repression of Ovine FSH receptor gene via a pleiotropic nuclear receptor response element. Biol. Reprod. 67: 204-211, 2002.

Danilovich, N. and Sairam, M.R. Haploinsufficiency of the follicle stimulating hormone receptor accelerates oocyte loss inducing early reproductive senescence and biological aging in mice. Biol. Reprod. 67: 361-369, 2002.

Danilovich, N., Javeshghani, D., Xing, W., and Sairam, M.R. Endocrine alterations and signaling changes associated with declining ovarian function and advanced biological aging in FSH receptor haploinsufficient mice. Biol. Reprod. 67: 370-378, 2002.

Danilovich, N., Roy, I., and Sairam, M.R. Emergence of uterine pathology during accelerated biological aging in FSH receptor haploinsufficient mice. Endocrinology 143: 3618-3627, 2002.

Tam, J., Danilovich, N., Nilsson, K., Sairam, M.R., and Maysinger, D. Chronic estrogen deficiency leads to molecular aberrations related to neurodegenerative changes in follitropin receptor knockout female mice. Neuroscience 114: 493-506, 2002.

Xing, W. and Sairam, M.R. Cross-talk of two Krupple transcription factors regulate expression of the ovine FSH receptor gene. Biochem. Biophys. Res Commun. 295: 1096-1101, 2002

Sairam, M.R. and Bhargavi, G.N.: A role for glycosylation of the a subunit in transduction of biological signal in glycoprotein hormones. Science 229: 65 67, 1985.