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Research unit director
Publications

Selected publications

Click here for a complete list of publications through PubMed.

Ferron, M., Lacombe, J., Germain, A., Oury, F. and Karsenty, G*. (2015) GGCX and VKORC1 inhibit osteocalcin endocrine functions. J Cell Biol. 208, 2015 Mar 9

Huesa, C., Zhu, D., Glover, J.D., Ferron, M., Karsenty, G., Milne, E.M., Milla, J.L., Ahmed, F.S., Farquharson, C., Morton, N.M. and MacRae, V.E. (2014) Deficiency of the bone mineralization inhibitor NPP1 protects against obesity and diabetes.
Dis Model Mech. 2014 Dec;7(12):1341-50.

Bornstein S, Brown SA, Le PT, Wang X, DeMambro V, Horowitz MC, MacDougald O, Baron R, Lotinun S, Karsenty G, Wei W, Ferron M, Kovacs CS, Clemmons D, Wan Y, Rosen CJ. (2014) FGF-21 and Skeletal Remodeling During and After Lactation in C57BL6 Mice. Endocrinology. 2014 Sep;155(9):3516-26.

Riddle, R.C., Frey, J.L., Tomlinson, R.E., Ferron, M., Li, Y., Digirolamo, D.J., Faugere, M.C., Hussain, M.A., Karsenty, G., Clemens, T.L. Tsc2 is a molecular checkpoint controlling osteoblast development and glucose homeostasis. Mol Cell Biol. 2014 May;34(10):1850-62.

Wei, J., Ferron, M., Clarke, C.J., Hannun, Y.A., Jiang, H., Blanner, W.S., Karsenty, G. Insulin resistance in bone: molecular bases and metabolic consequences. J Clin Invest. 2014 Apr;124(4):1-13

Ferron M, Lacombe J.(2014) Regulation of energy metabolism by the skeleton: Osteocalcin and beyond. Arch Biochem Biophys. 2014 Nov 1;561C:137-146. Nohara K, Liu S, Meyers MS, Waget A, Ferron M, Karsenty G, Burcelin R, Mauvais-Jarvis F. Developmental androgen excess disrupts reproduction and energy homeostasis in adult male mice. J Endocrinol. 2013 Nov 6;219 (3):259-68.

Gillespie JR, Bush JR, Bell GI, Aubrey LA, Dupuis H, Ferron M, Kream B, DiMattia G, Patel S, Woodgett JR, Karsenty G, Hess DA, Beier F. GSK-3β function in bone regulates skeletal development, whole-body metabolism, and male life span. Endocrinology.2013 Oct;154(10):3702-18.

Nohara K, Liu S, Meyers MS, Waget A, Ferron M, Karsenty G, Burcelin R, Mauvais-Jarvis F. Developmental androgen excess disrupts reproduction and energy homeostasis in adult male mice. J Endocrinol. 2013 Nov 6;219 (3):259-68.

Gillespie JR1, Bush JR, Bell GI, Aubrey LA, Dupuis H, Ferron M, Kream B, DiMattia G, Patel S, Woodgett JR, Karsenty G, Hess DA, Beier F. GSK-3β function in bone regulates skeletal development, whole-body metabolism, and male life span. Endocrinology.2013 Oct;154(10):3702-18.

Kajimura D1, Lee HW, Riley KJ, Arteaga-Solis E, Ferron M, Zhou B, Clarke CJ, Hannun YA, DePinho RA, Guo EX, Mann JJ, Karsenty G. Adiponectin regulates bone mass via opposite central and peripheral mechanisms through FoxO1. Cell Metab. 2013 Jun 4; 17(6):901-15.

Nohara K1, Waraich RS, Liu S, Ferron M, Waget A, Meyers MS, Karsenty G, Burcelin R, Mauvais-Jarvis F. Developmental androgen excess programs sympathetic tone and adipose tissue dysfunction and predisposes to a cardiometabolic syndrome in female mice. Am J Physiol Endocrinol Metab. 2013 Jun 15;304(12):E1321-30.

Wei J, Ferron M, Clarke CJ, Hannun YA, Jiang H, Blaner WS, Karsenty G. Bone-specific insulin resistance disrupts whole-body glucose homeostasis via decreased osteocalcin activation. J Clin Invest. 2014 Apr;124(4):1-13. 

Riddle RC, Frey JL, Tomlinson RE, Ferron M, Li Y, Digirolamo DJ, Faugere MC, Hussain MA, Karsenty G, Clemens TL. PMID:    24591652. Tsc2 is a molecular checkpoint controlling osteoblast development and glucose homeostasis. Mol Cell Biol. 2014 May;34(10):1850-62.

Oury, F., Ferron, M., Xu, L., Confavreux, C., Srinivas, P., Lacombe, J., Huizhen, W., Lugani, F., Lejeune, H., Kumar, T.R., Plotton, I., Karsenty, G. Evidence for a pancreas-bone-testis axis favoring male fertility. J Clin Invest. 2013 Jun;123(6):2421-33.

Ferron, M. Settembre, C., Shimazu, J., Lacombe, J., Kato, S., Rawlings, D.J., Ballabio, A., Karsenty, G. (2013) A RANKL-PKCβ-TFEB signaling cascade is necessary for lysosomal biogenesis in osteoclasts. Genes Dev. 2013 Apr 15;27(8):955-69.

Karsenty, G., Ferron, M. (2012) Whole-organism Physiology and the Skeleton: Bone Mass and Beyond Nature. 2012 Jan 18;481(7381):314-20.

Ferron, M., McKee, M.D., Levine, R.L., Ducy, P., Karsenty, G. (2012) Intermittent Injections of Osteocalcin Improve Glucose Metabolism and Prevent Type 2 Diabetes in Mice. Bone. 2012 Feb;50(2):568-75. 

Ferron, M., Boudiffa, M., Arsenault, M., Rached, M., Pata, M., Giroux, S., Elfassihi, L., Kisseleva, M., Majerus, P.W., Rousseau, F., Vacher, J. (2011) Inositol Polyphosphate 4-Phosphatase B as a Regulator of Bone Mass in Mice and Humans Cell Metab. 2011 Oct 5;14(4):466-77.

Oury, F., Sumara, G., Sumara, O., Ferron, M., Chang, H., Smith, C.E., Hermo, L., Suarez, S., Roth, B.L., Ducy, P., Karsenty, G. (2011) Endocrine Regulation of Male Fertility by the Skeleton Cell. 2011 Mar 4;144(5):796-809.. 

Ferron, M., Wei, J., Yoshizawa, T., Del Fattore, A., DePinho, R.A., Teti, A., Ducy, P. and Karsenty, G. (2010) Insulin Signaling in Osteoblasts Integrates Bone Remodeling and Energy Metabolism. Cell. 142, 296-308.

Ferron, M., Wei, J., Yoshizawa, T., Ducy, P. and Karsenty, G. (2010) An ELISA-Based Method to Quantify Osteocalcin Carboxylation in Mice. Biochem Biophys Res Commun. 2010 Jul 9;397(4):691-6..

Ferron, M., Hinoi, E., Karsenty, G., Ducy, P. (2008) Osteocalcin Differentially Regulates β-Cell and Adipocyte Gene Expression and Affects the Development of Metabolic Diseases in Wild-Type Mice. Proc Natl Acad Sci U S A. 2008 Apr 1;105(13):5266-70. .

Lee, N.K., Sowa, H., Hinoi, E., Ferron, M., Ahn, J.D., Confavreux, C., Dacquin, R., Mee, P.J., McKee, M.D., Jung, D.Y., Zhang, Z., Kim, J.K., Mauvais-Jarvis, F., Ducy, P., Karsenty, G. (2007) Endocrine Regulation of Energy Metabolism by the Skeleton. Cell. 2007 Aug 10;130(3):456-69..

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