The brain is composed of billions of neurons that form a complex network. Inappropriate wiring of these neuronal connections has serious consequences for the sensory, motor and cognitive functions of the nervous system. During embryonic development, axons extend to their target via attractive and repulsive molecular guidance molecules. We have recently demonstrated that a molecule called Sonic Hedgehog (Shh) acts as a chemo-attractive molecule for the axons of certain neurons in the spinal cord.
One of Dr. Charron’s objectives is to identify and characterize the components of the Shh signalling pathway in axonal guidance. In addition to helping us understand the immense complexity underlying the wiring of the nervous system, this work will help to identify novel strategies to promote the proper guidance and rewiring of axons damaged by neurodegenerative diseases and brain or spinal cord injuries.
Affiliations of the Laboratory:
McGill UniversityDepartment of Medicine, Division of Experimental MedicineDepartment of BiologyDepartment of Anatomy and Cell BiologyIntegrated Program in NeuroscienceProgram in Neuroengineering
Université de MontréalDepartment of MedicineProgram in Molecular BiologyCentre of Excellence in Neuromics of Université de Montréal (CENUM)
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