The Clinic
Studying at IRCM
Core facilities
Genetics and Development
Skip navigation links
Contact us

Research unit director

View list of publications on external link


Selected publications

Sheth R., Bastida M.F., Kmita M.*, Ros M.* (2014)
"Self-regulation," a new facet of Hox genes' function
Developmental Dynamics doi: 10.1002/dvdy.24019. Epub ahead of print 2013 Jul 31
* corresponding authors and co-senior
Berlivet S.,
Paquette D., Dumouchel A., Langlais D., Dostie J.* and Kmita M.* (2013)
Clustering of tissue-specific sub-TADs accompanies the regulation of HoxA genes in developing limbs.
PLOS Genetics 9(12):e1004018.doi:10.1371/journal.pgen.1004018
* corresponding authors
Langlais D., Couture C., Kmita M., Drouin J. (2013)
Adult pituitary cell maintenance: lineage-specific contribution of self-duplication
Molecular Endocrinology 27(7):1103-12. Epub 2013 Jun 10.
Sheth R., Grégoire D., Dumouchel A., Scotti M., Pham J.M., Nemec S., Bastida M.F., Ros M.A., and Kmita M. (2013)
Decoupling the function of Hox and Shh in developing limb reveals multiple inputs of Hox genes on limb growth.
Development 140(10):2130-8.
Sheth R.*, Marcon L.*, Bastida M.F., Junco M., Quintana L., Dahn R., Kmita M. #, Sharpe J.# and  Ros M.A.# ( 2012)
Hox genes regulate digit patterning by controlling the wavelength of a Turing-type mechanism.
Science 14;338(6113):1476-80.doi:10.1126/science.1226804. 
* indicates equal contribution and # indicates corresponding authors

Lopez-Rios J., Speziale D., Robay D., Scotti M., Osterwalder M., Nusspaumer G., Galli A., Holländer G.A., Kmita M and Zeller R. (2012)
GLI3 Constrains digit number by controlling both progenitor proliferation and BMP-dependent exit to chondrogenesis 
Dev Cell 22(4):837-48. Epub 2012 Mar 29.

Scotti, M. and Kmita, M. (2012) 
Recruitment of 5’Hoxa genes in the allantois is essential for proper extra-embryonic function in placental mammals.
Development 139(4):731-9. doi:10.1242/dev.075408.Epub 2012 Jan 4.

Kawakami, Y., Uchiyama, Y., Rodriguez Esteban, C., Inenaga, T., Koyano-Nakagawa, N., Kawakmi, H., Marti, M., Kmita, M., Monaghan-Nichols, P., Nishinakamura, R., Izpisua Belmonte, J.C.  (2009)
Sall genes regulate region-specific morphogenesis in the mouse limb by modulating Hox activities

Development. 136(4):585-94

Minoux, M., Antonarakis, G.S., Kmita, M., Duboule, D., Rijli F.M. (2009)
Rostral and caudal pharyngeal arhes share a common neural crest ground pattern.
Development. 136(4):637-45

Grégoire, D. and Kmita, M. (2008)
Recombination between inverted loxP sites in cytotoxic for proliferating cells and provide a simple tool for conditional cell ablation.
Proc Natl Acad Sci U S A. 105(38):14492-14496. Epub 2008, Sep 11.

Morey, C. Da Silva, NR., Kmita, M., Duboule, D., Bickmore, WA. (2008)
Ectopic nuclear reorganisation driven by a Hoxb1 transgene transposed into Hoxd.
J Cell Sci. 1;121(Pt 5):571-7. Epub 2008 Feb 5

Tarchini, B., Duboule, D. and Kmita, M. (2006)
Regulatory constraints in the evolution of the tetrapod limb anterior posterior polarity.
Nature 443(7114):985-988

Kmita, M., Tarchini, B., Zàkàny, J., Logan, M., Tabin, C.J., Duboule, D. (2005)
Early developmental arrest of mammalian limbs lacking HoxA/HoxD gene function.
Nature 435(23): 1113-1116

Zàkàny, J., Kmita, M., Duboule, D. (2004)
A dual role for Hox genes in limb anterior-posterior asymmetry.
Science 304(5677):1669-1672

Kmita, M. and Duboule, D. (2003)
Organizing axes in time and space; 25 years of colinear tinkering.
Science 301: 331-333

Kmita, M., Fraudeau, N., Herault, Y., Duboule, D. (2002)
Serial deletions and duplications suggest a mechanism for the collinearity of Hoxd genes in limbs.
Nature 420(14): 145-150

Other publications

Duboule, D., Tarchini, B., Zakany, J. and Kmita, M. (2007)
Tinkering with constraints in the evolution of the vertebrate lim anterior-posterior polarity.
Novartis Found Symp. 284:130-137

Stern, C.D., Charite, J., Deschamps, J., Duboule, D., Durston, A.J., Kmita, M., Nicolas, J.F., Palmeirim, I., Smith, J.C. and Wolpert, L. (2006)
Head-tail patterning of the vertebrate embryo: one, two or many unresolved problems?
Int J Dev Biol 50: 3-15

Kmita, M., Duboule, D. and Zàkàny, J. (2004)
Molecular genetic analysis of the role of the HoxD complex in skeletal development
in The Skeleton (ed. Massaro J.E., a. R. J. M.) 101-112 (Humana Press, Totowa, New Jersey, 2004)

Kmita, M., Tarchini, B., Duboule, D. and Herault, Y. (2002)
Evolutionary conserved sequences are required for the insulation of the vertebrate Hoxd complex in neural cells.
Development 129(23): 5521-5528

Herault, Y., Kmita, M., Sawaya, C.C., Duboule, D. (2002)
A nested deletion approach to generate Cre deleter mice with progressive Hox profiles.
Int J Dev Biol 46(1 Spec No): 185-191

Zàkàny, J., Kmita, M., Alarcon, P., de la Pompa, J.L., Duboule, D. (2001)
Localized and transient transcription of Hox genes suggests a link between patterning and the segmentation clock.
Cell 106(2):207-217

Kmita, M., Kondo, T., Duboule, D. (2000)
Targeted inversion of a polar silencer within the HoxD complex re-allocates domains of enhancer sharing.
Nature Genetic 26(4):451-454

Kmita, M., van Der Hoeven, F., Zakany, J., Krumlauf, R., Duboule, D. (2000)
Mechanisms of Hox gene colinearity: transposition of the anterior Hoxb1 gene into the posterior HoxD complex.
Genes and Development 14(2):198-211

Kmita-Cunisse, M., Loosli, F., Bierne, J., Gehring, W.J. (1998)
Homeobox genes in the ribbonworm Lineus sanguineus: evolutionary implications.
Proc Natl Acad Sci USA 17, 95(6):3030-3035

Loosli, F., Kmita-Cunisse, M., Gehring, W.J. (1996).
Isolation of a Pax-6 homolog from the ribbonworm Lineus sanguineus.
Proc Natl Acad Sci USA 93: 2658-2663

All rights reserved: IRCM 2011_110 avenue des Pins Ouest - Montréal (Québec) H2W 1R7 – Canada