The Clinic
Studying at IRCM
Core facilities
Molecular Genetics
Skip navigation links
Available positions
Contact us

Home > Molecular Genetics > Publications
Home > Molecular Genetics > Publications
Research unit director

Complete list of publications (PDF)

Click here for a list of IRCM publications through PubMed.

158      Drouin J, Transcriptional and epigenetic regulation of POMC gene expression. J Mol Endo 2016 56(4):T99-T112. Doi: 10.1530/JME-15-0289

157.    Roussel-Gervais A, Couture C, Langlais D, Takayasu S, Balsalobre A, Rueda B R, Zukerberg L R, Figarella-Branger D, Brue T, Drouin J. The Cables1 gene in glucocorticoid regulation of pituitary corticotrope   growth and Cushing disease. J Clin Endocrinol Metab, 2016, 101(2):513–522.

156.   Mayran A, Pelletier A, Drouin J, Pax factors in transcription and epigenetic remodelling, Semin Cell Dev Biol. 2015: S1084-9521(15)00134-2.

155.      van Rijn SJ1, Pouwer MG2, Tryfonidou MA2, Grinwis GC3, van der Bend JE2, Beukers PE2, Vastenhout N2, Drouin J4, Penning LC2, Meij BP2. Expression and clinical relevance of paired box protein 7 and sex determining region Y-box 2 in canine corticotroph pituitary adenomas. Vet J. 2015; 204(3):315-21.

154.   Brue T, Quentien M-H, Khetchoumian K, Bensa M, Capo-Chichi J, Delemer B, Balsalobre A, Nassif C, Papadimitriou T D, Pagnier A, Hasselmann C, Patry L, Schwartzentruber J, Souchon P-F, Takayasu S, Enjalbert A, Van Vliet G, Majewski J, Drouin J, Samuels E M, Mutations in NFKB2 and potential genetic heterogeneity in patients with DAVID syndrome, having variable endocrine and immune deficiencies BMC Medical Genetics 2014 19;15(1):139.

153.   Bifsha P, Yang J, Fisher R.A, Drouin J,Rgs6 is required for adult maintenance of dopaminergic neurons in the ventral substantia nigra, Plos Genetics  PLoS Genet. 2014 Dec 11;10(12):e1004863

152.     Drouin J, Pioneer transcription factors in cell fate specification, Molecular Endocrinology 2014 Jul;28(7):989-98

151.     L’Honoré A, Commère P-A, Ouimette J-F, Montarras D, Drouin J, and Buckingham M, Redox regulation by Pitx2 and Pitx3 is critical for foetal myogenesis Developmental Cell. 2014   May, 29, (4): 392–405

150.   Marinoni I, Lee M, Mountford S, Perren A, Bravi I, Jennen L, Feuchtinger A, Drouin J, Roncaroli F, Pellegata NS. Characterization of MENX-associated pituitary tumours. Neuropathol Appl Neurobiol. 2013 Apr; 39(3):256-69.

149.     Langlais D, Couture C, Kmita M, Drouin J, Adult pituitary cell maintenance: lineage-specific contribution of self-duplication, Mol Endocrinol 2013, 27(7):1103-1112

148.     Luk K, Rymar V, Van den Munckhof P, Nicolau S, Steriade C, Bifsha P, Drouin J, Sadikot A, The transcription factor Pitx3 is expressed selectively in midbrain dopaminergic neurons susceptible to neurodegenerative stress,  Journal of Neurochemistry 2013 Jun;125(6):932-43

147.     Lichtenauer U, Shapiro U, Sackmann S, Drouin J, Scheele J, Maneck M, Klein C, Reincke M, and Beuschlein F, The side population phenomenon enriches for designated adrenocortical progenitor cells in mice. J Endocrinol 2012, 215(3):383-391

146.     Budry L, Balsalobre A, Gauthier Y, Khetchoumian K, L’Honoré A, Vallette S, Brue T, Figarella-Branger D, Meij B, Drouin J, The selector gene Pax7 dictates alternate pituitary cell fates through its pioneer action on chromatin remodeling. Genes and Dev. 2012, 26(20):2299-2310

145.     Langlais D, Couture C, Balsalobre A, Drouin J. The Stat3/GR interaction code: predictive value of direct/indirect DNA recruitment for transcription outcome. Mol Cell 2012, 47(1):38-49

144.     Mollard P, Hodson DJ, Lafont C, Rizzoti K, Drouin J. A tri-dimensional view of pituitary development and function. Trends Endocrinol Metab. 2012, 23(6):261-9

143.     Couture C, Saveanu A, Barlier A, Carel JC, Fassnacht M, Flück CE, Houang M, Maes M, Phan-Hug F, Enjalbert A, Drouin J, Brue T, Vallette S. Phenotypic Homogeneity and Genotypic Variability in a Large Series of Congenital Isolated ACTH-Deficiency Patients with TPIT Gene Mutations. J Clin Endocrinol Metab 2012, 97(3):E486-95

142.     McEachern R, Drouin J, Metherell L, Huot C, Van Vliet G, Deal C. Severe cortisol deficiency associated with reversible growth hormone deficiency in two infants: what is the link? J Clin Endocrinol Metab 2011, 96(9):2670-2674

141.     Budry L, Lafont C, El Yandouzi T, Chauvet N, Conéjero G, Drouin J, Mollard P. Related pituitary cell lineages develop into interdigitated 3D cell networks. Proc Nat Acad Sci 2011, 108(30):12515-12520

140.     Budry L, Couture C, Balsalobre A, Drouin J. The Ets factor Etv1 interacts with Tpit for pituitary POMC transcription. J Biol Chem 2011, 286(28):25387-25396

139.     Langlais D, Couture C, Sylvain-Drolet G, Drouin J. A pituitary-specific enhancer of the POMC gene with preferential activity in corticotrope cells. Mol Endocrinol 2011, 25(2):348-359

138.     L’Honoré A, Ouimette JF, Lavertu-Jolin M, Drouin J. Pitx2 defines alternate pathways acting through MyoD during limb and somitic myogenesis. Development 2010, 137:3847-3856; doi:10.1242/dev.053421

137.     Roussel-Gervais A, Bilodeau S, Vallette S, Berthelet F, Lacroix A, Figarella-Branger D, Brue T, Drouin J. Cooperation between cyclin E and p27Kip1 in pituitary tumorigenesis. Mol Endocrinol 2010, 24(9):1835-1845

136.     Ouimette JF, Lavertu Jolin M, L’honoré A, Gifuni A, Drouin J. Divergent transcriptional activities determine hindlimb identity. Nature Comm 2010, Jul 13; 1(4):1-9; doi:10.1038

135.     Rambaud J, Desroches J, Balsalobre A, Drouin J. TIF1b/KAP-1 is a coactivator of the orphan nuclear receptor NGFI-B/Nur77. J Biol Chem 2009, 284(21):14147-14156

134.     Bilodeau S, Roussel-Gervais A, Drouin J. Distinct developmental roles of cell cycle inhibitors p57Kip2 and p27Kip1 distinguish pituitary progenitor cell cycle exit from cell cycle re-entry of differentiated cells. Mol Cell Biol 2009, 29(7):1895-1908

133.     Langlais D, Couture C, Balsalobre A, Drouin J. Genome-wide potentiation of LIF signaling by glucocorticoids reveals an innate cell defense response. PLoS Genet 2008, 4(10):e1000224

132.     Shima Y, Zubair M, Komatsu T, Oka S, Yokoyama C, Tachibana T, Hjalt TA, Drouin J,  Morohashi Ki. Pitx2 regulates Ad4BP/SF-1 gene transcription in the pituitary gonadotrope through interaction with the intronic enhancer. Mol Endocrinol 2008, 22(7):1633-1646

131.     Lavoie PL, Budry L, Balsalobre A, Drouin J,  Developmental dependence on NurRE and EboxNeuro for expression of pituitary POMC. Mol Endocrinol 2008, 22(7):1647-1657

130.     De Langhe SP, Carraro G, Tefft D, Li C, Xu X, Chai Y, Minoo P, Hajihosseini MK, Drouin J, Kaartinen V, Bellusci S. Formation and differentiation of multiple mesenchymal lineages during lung development is regulated by b-catenin signaling. PLoS ONE 2008, 3(1), e1516:1-12

129.     Mitsiadis TA, Drouin J. Deletion of the Pitx1 genomic locus affects mandibular tooth morphogenesis and expression of the Barx1 and Tbx1 genes. Dev Biol 2008, 313(2):887-896

128.   Hanson JM, Mol JA, Leegwater PAJ, Bilodeau S, Drouin J, Meij BP. Expression and mutation analysis of Tpit in the canine pituitary gland and corticotroph adenomas. Domest Anim Endocrinol 2008, 34(3):217-222


127.     Coulon V, L’Honoré A, Ouimette JF, Dumontier, É, van den Munckhof P, Drouin J. A muscle-specific promoter directs Pitx3 gene expression in skeletal muscle cells. J Biol Chem 2007, 282(45):33192-33200

126.     Keller DM, McWeeney S, Arsenlis A, Drouin J, Wright CV, Wang H, Wollheim CB, White P, Kaestner KH, Goodman RH. Characterization of pancreatic transcription factor Pdx-1 binding sites using promoter microarray and serial analysis of chromatin occupancy. J Biol Chem 2007, 282(44):32084-32092

125.     Vallette-Kasic S, Couture C, Balsalobre A, Gauthier Y, Metherell L, Dattani M, Drouin J. The Tpit gene mutation M86R associated with isolated ACTH deficiency interferes in protein:protein interactions. J Clin Endocrinol Metab 2007, 92(10), 3991-3999

124.     Drouin J, Bilodeau S, Vallette S. Of old and new diseases: genetics of pituitary ACTH excess (Cushing) and deficiency. Clin Genet 2007, 72:175-182

123.     L’Honoré A, Coulon V, Marcil A, Lebel M, Lafrance-Vanasse J, Gage P, Camper SA, Drouin J. Sequential expression and redundancy of Pitx2 and Ptix3 genes during muscle development. Dev Biol 2007, 307(2):421-433

122.     Bilodeau S, Vallette-Kasic S, Gauthier Y, Figarella-Branger D, Brue T, Berthelet F, Lacroix A, Batista D, Stratakis C, Hanson J, Meij B, Drouin J. Role of Brg1 and HDAC2 in GR trans-repression of pituitary POMC gene and misexpression in Cushing disease. Genes Dev 2006, 20(20):2871-2886

121.     Weintrob N, Drouin J, Vallette-Kasic S, Taub E, Marom, D, Lebenthal Y, Klinger G, Bron-Harlev E, Shohat M. Low estriol levels in the maternal triple-marker screen as a predictor of isolated ACTH deficiency caused by a new mutation in the TPIT gene. Pediatrics 2006, 117(2):e322-327

120.     van den Munckhof P, Gilbert F, Chamberland M, Lévesque D, Drouin J. Striatal neuroadaptation and rescue of locomotor deficit by L-dopa in aphakia mice, a model of Parkinson’s disease. J Neurochem 2006, 96(1):160-170

119.     Charles MA, Suh H, Hjalt T, Drouin J, Camper SA, Gage PJ. PITX genes are required for cell survival and Lhx3 activation. Mol Endodrinol 2005, 19(7):1893-1903

118.     Batsché E, Desroches J, Bilodeau S, Gauthier Y, Drouin J. Rb enhances p160/SRC coactivator-dependent activity of nuclear receptors and hormone responsiveness. J Biol Chem 2005, 280(20):19746-19756

117.     Batsché E, Moschopoulos P, Drouin J. Retinoblastoma and the related pocket protein p107 act as coactivators of NeuroD1 to enhance gene transcription. J Biol Chem 2005, 280(16):16088-16095

116.     Nudi M, Ouimette JF, Drouin J. Bmp (Smad)-mediated repression of POMC transcription by interference with Pitx/Tpit activity. Mol Endocrinol 2005, 19:1329-1342

115.     Martens M, Bilodeau, S, Maira M, Gauthier Y, Drouin J. Protein:protein interactions and transcriptional antagonism between the subfamily of NGFI-B/Nur77 orphan nuclear receptors and glucocorticoid receptor. Mol Endocrinol 2005, 19:885-897

114.     Vallette-Kasic S, Brue T, Pulichino AM, Gueydan M, Barlier A, David M, Nicolino M, Malpuech G, Dechelotte P, Deal C, Van Vliet G, De Vroede M, Riepe FG, Partsch CJ, Sippell WG, Berberoglu M, Atasay B, de Zegher F, Beckers D, Kyllo J, Donohoue P, Fassnacht M, Hahner S, Allolio B, Noordam C, Dunkel L, Hero M, Pigeon B, Weill J, Yigit S, Brauner R, Heinrich JJ, Cummings E, Riddell C, Enjalbert A, Drouin J. Congenital isolated adrenocorticotropin deficiency: an underestimated cause of neonatal death, explained by TPIT gene mutations. J Clin Endocrinol Metab 2005, 90(3):1323-1331

113.     Pulichino AM, Vallette-Kasic S, Couture C, Brue T, Drouin J. Mutations du facteur de transcription Tpit et différenciation hypophysaire. Médecine/science 2004, 20(11):1009-1013

112.     Lamolet B, Poulin G, Chu K, Guillemot F, Tsai MJ, Drouin J. Tpit-independent function of NeuroD1 (BETA2) in pituitary corticotroph differentiation. Mol Endocrinol 2004, 18:995-1003

111      Pulichino AM, Vallette-Kasic S, Drouin J. Transcriptional regulation of pituitary gland development: binary choices for cell differentiation. Curr Opin Endocrinol Diabetes 2004, 11(1):13-17


110.     Maira M, Couture C, Le Martelot G, Pulichino AM, Bilodeau S, Drouin J. The T-box factor Tpit recruits SRC/p160 coactivators and mediates hormone action. J Biol Chem 2003, 278:46523-46532

109.     Auwerx J, Drouin J, Laudet V. Récepteurs à la provençale - EMBO workshop on the Biology of Nuclear Receptors. EMBO Rep, 2003, 4(12):1122-1126

108.     Goodyer CG, Tremblay JJ, Paradis FW, Marcil A, Lanctôt C, Gauthier Y, Drouin J. PIitx1 in vivo promoter activity and mechanisms of positive autoregulation. Neuroendocrinol 2003, 78:129-137

107.     Bobola N, Carapuço M, Ohnemus S, Kanzler B, Leibbrandt A, Neubüser A, Drouin J, Mallo M. Mesenchymal patterning by Hoxa2 requires blocking Fgf-dependent activation of Ptx1. Development 2003, 130, 3403-3414

106.     Vallette-Kasic S, Figarella-Branger D, Grino M, Pulichino AM, Dufour H, Grisoli F, Enjalbert A, Drouin J, Brue T. Differential regulation of proopiomelanocortin and pituitary-restricted transcription factor (TPIT), a new marker of normal and adenomatous human corticotrophs. J Clin Endocrinol Metab 2003, 88(7):3050-3056

105.     van den Munckhof P, Luk KC, Ste-Marie L, Montgomery J, Blanchet PJ, Sadikot AF, Drouin J. Pitx3 is required for motor activity and for survival of a subset of midbrain dopaminergic neurons. Development 2003, 130:2535-2542

104.     Pulichino AM, Vallette-Kasic S, Tsai JPY, Gauthier Y, Drouin J. Tpit determines alternate fates during pituitary cell differentiation. Genes Dev 2003, 17:738-747

103.     Pulichino AM, Vallette-Kasic S, Couture C, Gauthier Y, Brue T, David M, Malpuech G, Deal C, Van Vliet G, De Vroede M, Riepe FG, Partsch CJ, Sippell WG, Berberoglu M, Atasay B, Drouin J. Human and mouse Tpit gene mutations cause early onset pituitary ACTH deficiency. Genes Dev 2003, 17:711-716

102.     Maira M, Martens C, Batsché É, Gauthier Y, Drouin J. Dimer-specific potentiation of NGFI-B (Nur77) transcriptional activity by the protein kinase A pathway and AF-1-dependent coactivator recruitment. Mol Cell Biol 2003, 23:763-776

101.     Marcil A, Dumontier É, Chamberland M, Camper SA, Drouin J. PITX1 and PITX2 are required for development of hindlimb buds. Development 2003, 130:45-55

100.     Island ML, Mesplede T, Darracq N, Bandu MT, Christeff N, Djian P, Drouin J, Navarro S. Repression by homeoprotein Pitx1 of virus-induced interferon A promoters is mediated by physical interaction and trans repression of IRF3 and IRF7. Mol Cell Biol 2002, 22:7120-7133

99.       Suh H, Gage PJ, Drouin J, Camper SA. Pitx2 is required at multiple stages of pituitary organogenesis: pituitary primordium formation and cell specification. Development 2002, 129:329-337

98.       Pulichino AM, Lamolet B, Brue T, Enjalbert A, David M, Malpuech G, Drouin J. Tpit, un nouveau membre de la famille des gènes à boîte T, est impliqué dans la déficience isolée en ACTH. Médecine/sciences 2001, 17:1203-1207

97.       Steff AM, Trop S, Maira M, Drouin J, Hugo P. Opposite ability of pre-TCR and abTCR to induce apoptosis. J Immunol 2001, 166:5044-5050

96.       Lamolet B, Pulichino AM, Lamonerie T, Gauthier Y, Brue T, Enjalbert A, Drouin J. A pituitary cell-restricted T-box factor, Tpit, activates POMC transcription in cooperation with Pitx homeoproteins. Cell 2001, 104:849-859

95.       Lebel M, Gauthier Y, Moreau A, Drouin J. Pitx3 activates mouse tyrosine hydroxylase promoter via a high affinity binding site. J Neurochem 2001, 77:558-567

94.       Drouin J. Gènes sélecteurs, identité des membres et latéralité chez les vertébrés. Médecine/sciences 2000, 16:181-185

93.       Lopez S, Island M.L., Drouin J, Bandu MT, Christeff N, Darracq N, Barbey R, Doly J, Thomas D, Navarro S. Repression of virus-induced interferon A promoters by the homeodomain transcription factor Ptx1. Mol Cell Biol 2000, 20:7527-7540

92.       Poulin G, Lebel M, Chamberland M, Paradis FW, Drouin J. Specific protein interaction between basic Helix-Loop-Helix transcription factors and homeoproteins of the Pitx family. Mol Cell Biol, 2000, 20(13):4826-4837

91.       Tremblay JJ, Goodyer CG, Drouin J. Transcriptional properties of Ptx1 (Pitx1) and Ptx2 (Pitx2) isoforms. Neuroendocrinology 2000, 71:277-286

90.       Maira MH, Martens C, Philips A, Drouin J. Heterodimerization between members of the Nur subfamily of orphan nuclear receptors as a novel mechanism for gene activation. Mol Cell Biol 1999, 19:7549-7557

89.       Tremblay JJ, Marcil A., Gauthier Y, Drouin J. Ptx1 regulates SF-1 activity by an interaction that mimics the role of the ligand binding domain. EMBO J 1999, 18:3431-3441

88.       Elchebly M, Wagner J, Kennedy TE, Lanctôt C, Michaliszyn E, Itié A, Drouin J, Tremblay ML. Neuroendocrine dysplasia in mice lacking protein tyrosine phosphatases s. Nat Genet 1999, 21:330-333

87.       Lanctôt C, Moreau A, Chamberland M, Tremblay ML, Drouin J. Hindlimb patterning and mandible development require the Ptx1 gene. Development 1999, 126:1805-1810

85.       Lanctôt C, Gauthier Y, Drouin J. Pituitary homeobox 1 (Ptx1) is differentially expressed during pituitary development. Endocrinol 1999, 140:1416-1422

86.       Tremblay JJ, Drouin J. Egr-1 is a downstream effector of GnRH and synergizes by direct interaction with Ptx1 and SF-1 to enhance luteinizing hormone b gene transcription. Mol Cell Biol 1999, 19:2567-2576

84.       Maira M, Philips A, Drouin J. Signalisation par le récepteur orphelin Nur77 : nouveau mécanisme d'action et antagonisme par les glucocorticoïdes. Médecine/sciences 1998, 14:1217-1221

83.       Drouin J, Lanctôt C, Tremblay JJ. La famille Ptx de facteurs de transcription à boîte homéodomaine. Médecine/sciences 1998, 14:335-339

82.       Drouin J, Lamolet B, Lamonerie T, Lanctôt C, Tremblay JJ. The Ptx family of homeodomain transcription factors during pituitary development. Mol Cell Endocrinol 1998, 140:31-36

81.       Drouin J, Maira M, Philips A. Novel mechanism of action for Nur77 and antagonism by glucocorticoids:  a convergent mechanism for CRH activation and glucocorticoid repression of POMC gene transcription. J Steroid Biochem Mol Biol 1998, 65:59-63

80.       Acampora D, Mazan S, Tuorto F, Avantaggiato V, Lazzaro D, di Carlo A, Mariano A, Macchia PE, Macchia V, Tremblay JJ, Drouin J, Brûlet P, Simeone S. Transient dwarfism and hypogonadism in mice lacking Otx1 reveal prepubescent stage-specific control of pituitary levels of GH, FSH and LH. Development 1998, 125:1229-1239

79.       Tremblay JJ, Lanctôt C, Drouin J. The Pan-pituitary activator of transcription, Ptx-1, acts in synergy with SF-1 and Pit1, and is an upstream regulator of the Lim-homeodomain gene Lim3/Lhx3. Mol Endocrinol 1998, 12:428-441

78.       Smidt MP, van Schaick HSA, Lanctôt C, Tremblay JJ, Cox JJ, van der Kleij AAM, Wolterink G, Drouin J, Burbach P. A homeodomain gene PTX3 has highly restricted expression in mesencephalic dopaminergic neurons. Proc Natl Acad Sci USA 1997, 94:13305-13310

77.       Poulin G, Turgeon B, Drouin J. NeuroD/BETA2 contributes to cell-specific transcription of the POMC gene. Mol Cell Biol 1997, 17:6673-6682

76.       Crawford MJ, Lanctôt C, Tremblay JJ, Jenkins N, Gilbert D, Copeland N, Beatty B, Drouin J. Human and murine PTX1/Ptx1 gene maps to the region for Treacher Collins syndrome. Mamm Gen 1997, 8:841-845

75.       Philips A, Maira MH, Mullick A, Chamberland M, Lesage S, Hugo P, Drouin J. Antagonism between Nur77 and glucocorticoid receptor for control of transcription. Mol Cell Biol 1997, 17:5952-5959

74.       Philips A, Lesage S, Gingras R, Maira MH, Gauthier Y, Hugo P, Drouin J. Novel dimeric Nur77 signaling mechanisms in endocrine and lymphoid cells. Mol Cell Biol 1997, 17:5946-5951

73.       Lanctôt C, Lamolet B, Drouin J. The bicoid-related homeoprotein Ptx1 defines the most anterior domain of the embryo and differentiates posterior from anterior lateral mesoderm. Development 1997, 124:2807-2817

72.       Lamonerie T, Tremblay JJ, Lanctôt C, Therrien M, Gauthier Y, Drouin J. Ptx1, a bicoid-related homeobox transcription factor involved in transcription of the pro-opiomelanocortin (POMC) gene. Genes Dev 1996, 10:1284-1295

71.       Drouin J. Les molécules du développement. Médecine/Sciences 1996, 12:143-145

70.       Fenrick R, Babinski K, McNicoll N, Therrien M, Drouin J, De Léan A. Cloning and functional expression of the bovine natriuretic peptide receptor-B (natriuretic factor R1c subtype). Mol Cell Biochem 1994, 137:173-182

69.       Argentin S, Ardati A, Tremblay S, Lihrmann I, Robitaille L, Drouin J, Nemer M. Developmental stage-specific regulation of ANF gene transcription in cardiac cells. Mol Cell Biol 1994, 14:777-790

68.       Drouin J. Répression transcriptionnelle: glucocorticoïdes et pro-opiomélanocortine. Médecine/Sciences 1993, 9:509-517

67.       Therrien M, Drouin J. Cell-specific helix-loop-helix factor required for pituitary expression of the pro-opiomelanocortin gene. Mol Cell Biol 1993, 13:2342-2353

66.       Drouin J, Sun YL, Chamberland M, Gauthier Y, De Léan A, Nemer M, Schmidt TJ. Novel glucocorticoid receptor complex with DNA element of the hormone-repressed POMC gene. EMBO J 1993, 12:145-156

65.       Drouin J, Sun YL, Tremblay S, Lavender P, Schmidt TH, De Léan A, Nemer M. Homodimer formation is rate-limiting for high affinity DNA binding by glucocorticoid receptor. Mol Endocrinol 1992, 6:1299-1309

64.       Argentin S, Sun YL, Schmidt T, Drouin J, Nemer M. A distal cis-acting promoter element mediates glucocorticoid stimulation of cardiac ANF gene transcription. J Biol Chem, 1991, 266:23315-23322

63.       Dagnino L, Drouin J, Nemer M. Differential expression of natriuretic peptide genes in cardiac and extracardiac tissues. Mol Endocrinol 1991, 5:1292-1300

62.       Therrien M, Drouin J. Pituitary pro-opiomelanocortin gene expression requires synergistic interactions of several regulatory elements. Mol Cell Biol 1991, 11:3492-3503

61.       Yang-Yen HS, Chambard JC, Sun YL, Smeal T, Schmidt TJ, Drouin J, Karin M. Transcriptional interference between cJun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein-protein interaction. Cell 1990, 62:1205-1215

60.       Drouin J, Sun YL, Nemer M. Regulatory elements of the pro-opimelanocortin gene: pituitary specificity and glucocorticoid repression. Trend Endocrinol Metab 1990, 1:219-225

59.       Drouin J, Sun YL, Nemer M. Glucocorticoid repression of pro-opiomelanocortin gene transcription. J Steroid Biochem 1989, 34:63-69

58.       Drouin J, Nemer M, Charron J, Gagner JP, Jeannotte L, Sun YL, Therrien M, Tremblay Y. Tissue-specific activity of the pro-opiomelanocortin (POMC) gene and repression by glucocorticoids. Proc 16th International Congress of Genetics, Genome 1989, 31:510-519

57.       Drouin J, Trifiro MA, Plante RK, Nemer M, Eriksson P, Wrange Ö. Glucocorticoid receptor binding to a specific DNA sequence is required for hormone-dependent inhibition of pro-opiomelanocortin gene transcription. Mol Cell Biol 1989, 9:5305-5314

56.       Thibault G, Nemer M, Drouin J, Lavigne JP, Ding J, Charbonneau C, Garcia R, Genest J, Jasmin G, Sole MJ, Cantin M. Ventricles as a major site of ANF synthesis and release in cardiomyopathic hamsters with heart failure. Circ Res 1989, 65:71-82

55.       Cantin M, Thibault G, Haile-Meskel H, Ding J, Milne RW, Ballak M, Charbonneau C, Nemer M, Drouin J, Garcia R, Genest J. Atrial natriuretic factor in the impulse-conduction system of rat cardiac ventricles. Cell Tissue Res 1989, 256:309-325

54.       Charron J, Richard-Foy H, Berard D, Hager GL, Drouin J. Independent glucocorticoid induction and repression of two contiguous responsive genes. Mol Cell Biol 1989, 9:3127-3131

53.       Gutkowska J, Nemer M, Sole MJ, Drouin J, Sirois P. Lung is an important source of atrial natriuretic factor in experimental cardiomyopathy. J Clin Invest 1989, 83:1500-1504

52.       Cantin M, Thibault G, Haile-Meskel H, Ding J, Nemer M, Drouin J, Garcia R, Genest J. Atrial natriuretic factor in the impulse conduction system of the heart. Trans Ass Am Phys 1988, C1:100-113

51.       Tremblay Y, Tretjakoff I, Peterson A, Antakly T, Zhang CX, Drouin J. Pituitary-specific expression and glucocorticoid regulation of a pro-opiomelanocortin (POMC) fusion gene in transgenic mice. Proc Natl Acad Sci USA 1988, 85:8890-8894

50.       Lavigne JP, Drouin J, Ding J, Thibault G, Nemer M, Cantin M. Atrial natriuretic factor (ANF) gene expression in the Brattleboro rat. Peptides 1988, 9:817-824

49.       Galipeau J, Nemer M, Drouin J. Ventricular activation of the atrial natriuretic factor gene in acute myocardial infarction. New Engl J Med 1988, 319:654-655

48.       Nemer M, Antakly T, Argentin S, Lavigne JP, Drouin J. Cloning and expression of the atrial natriuretic factor gene. Clinical Physiology and Biochemistry 1988, 6:163-170

47.       Drouin J, Lavigne JP, Nemer M. Expression du gène du facteur natriurétique des oreillettes:  un marqueur de l'hypertrophie ventriculaire. Union Méd Can 1988, 117:64-67

46.       Drouin J, Charron J, Gagner JP, Jeannotte L, Nemer M, Plante RK, Wrange Ö. Pro-opiomelanocortin gene: A model for nega­tive regulation of transcription by glucocorticoids. J Cell Biochem 1987, 35:293-304

45.       Jeannotte L, Burbach JPH, Drouin J. Unusual pro-opiomelanocortin ribonucleic acids in extrapituitary tissues: Intronless transcripts in testes and long Poly(A) tails in hypothalamus. Mol Endocrinol 1987, 1:749-757

44.       Gagner JP, Drouin J. Tissue-specific regulation of pituitary pro-opiomelanocortin gene transcription by corticotropin-releasing hormone, 3', 5'-cyclic adenosine monophosphate, and glucocorticoids. Mol Endocrinol 1987, 1:677-682

43.       Moote NJ, Chénier P, Mikhail M, Drouin J. A program for the graphic representation and manipulation of DNA sequences. CABIOS 1987, 3:189-192

42.       Jeannotte L, Trifiro MA, Plante RK, Chamberland M, Drouin J. Tissue-specific activity of the pro-opiomelanocortin gene promoter. Mol Cell Biol, 1987, 7:4058-4064

41.       Argentin S, Drouin J, Nemer M. Thyroid hormone stimulates rat pro-natriodilatin mRNA levels in primary cardiocyte cultures. Biochem Biophys Res Comm 1987, 146:1336-1341

40.       Nemer M, Sirois D, Drouin J. TaqI polymorphism at the 3' end of the human pronatriodilatin gene (hPND). Nucl Acids Res 1986, 14:8697

39.       Nemer M, Sirois D, Drouin J. XhoI polymorphism at the human pronatriodilatin (hPND) gene locus. Nucl Acids Res 1986, 14:8696

38.       Nemer M, Lavigne JP, Drouin J, Thibault G, Gannon M, Antakly T. Expression of atrial natriuretic factor gene in heart ventricular tissue. Peptides 1986, 7:1147-1152

37.       Charron J, Drouin J. Glucocorticoid inhibition of transcription from episomal pro-opiomelanocortin gene promoter. Proc Natl Acad Sci USA 1986, 83:8903-8907

36.       Yang-Feng TL, Floyd-Smith G, Nemer M, Drouin J, Franke U. The pronatriodilatin gene is located on the distal short arm of human chromosome 1 and on Mouse Chromosome 4. Am. J Hum Genet 1985, 37:1117-1128

35.       Argentin S, Nemer M, Drouin J, Scott GK, Kennedy BP, Davies PL. The gene for rat atrial natriuretic factor. J Biol Chemistry 1985, 260:4568-4571

34.       Drouin J, Chamberland M, Charron J, Jeannotte L, Nemer M. Structure of the rat pro-opiomelanocortin POMC) gene. FEBS Lett 1985, 193:54-58

33.       Gagner JP, Drouin J. Opposite regulation of pro-opiomelanocortin gene transcription by glucocorticoids and CRH. Molec Cell Endocrinol 1985, 40:25-32

32.       Zivin B, Condra JH, Dixon RAF, Seidah NG, Chrétien M, Nemer M, Chamberland M, Drouin J. Molecular cloning and characterization of DNA sequences encoding rat and human atrial natriuretic factors. Proc Natl Acad Sci USA 1984, 81:6325-6329

31.       Nemer M, Chamberland M, Sirois D, Argentin S, Drouin J, Dixon RA, Zivin RA, Condra JH. Gene structure of human cardiac hormone precursor, pro-natriodilatin. Nature 1984, 312:654-656

30.       Boileau G, Barbeau C, Jeannotte L, Chrétien M, Drouin J. Complete structure of the porcine pro-opiomelanocortin mRNA derived from the nucleotide sequence of cloned cDNA. Nucl Acids Res 1983, 11:8063-8071

29.       Anderson S, Bankier AT, Barrell BG, de Bruijn MHL, Coulson AR, Drouin J, Eperon IC, Nierlich DP, Roe BA, Sanger F, Schreier PH, Smith AJH, Staden R, Young IG. Sequence and organization of the human mitochondrial genome. Nature 1981, 290:457-465

28.       Drouin J, Labrie F. Interactions of l7-beta-estradiol and progesterone in the control of LH and FSH release in anterior pituitary cells in culture. Endocrinology 1981, 108:52-57

27.       Drouin J, Goodman HM. Most of the coding region of rat ACTH/b-LPH precursor gene lacks intervening sequences. Nature 1980, 288:610-613

26.       Barrell BG, Anderson S, Bankier AT, de Bruijn MHL, Chen E, Coulson AR, Drouin J, Eperon IC, Nierlich DP, Roe BA, Sanger F, Schreier PH, Smith AJH, Staden R, Young IG. Different pattern of codon recognition by mammalian mitochondrial tRNAs. Proc Natl Acad Sci USA 1980, 77:3164-3166

25.       Drouin J. Cloning of Human Mitochondrial DNA in Escherichia Coli. J Mol Biol 1980, 140:15-34

24.       Labrie F, Borgeat P, Drouin J, Beaulieu M, Lagacé L, Ferland L, Raymond V. Mechanism of action of hypothalamic hormones in the adenohypophysis. Ann Rev Physiol 1979, 41:555-567

23.       Barrell BG, Bankier AT, Drouin J. A different genetic code in human mitochondria. Nature 1979, 282:189-194

22.       Labrie F, Drouin J, Beaulieu M, Lagacé L, Raymond V, Ferland L. Action des oestrogènes au niveau hypothalamo-hypophysaire. Actualités gynécologiques, série 9, Masson & Cie, Paris, 1978, 253-260

21.       Lagacé L, Drouin J, Massicotte J, Labrie F. Effets spécifiques des stéroides sexuels au niveau hypophysaire sur la sécrétion des gonadotrophines. Union Méd Canada 1978, 107:572-574

20.       Labrie F, Lagacé L, Drouin J, De Léan A, Beaulieu M, Ferland L, Raymond V. Rôle spécifique des stéroides sexuels au niveau hypophysaire. Bull Schweiz Akad Med Wiss 1978, 34:171-190

19.       Labrie F, Drouin J, Ferland L, Lagacé L, Beaulieu M, De Léan A, Kelly PA, Caron MG, Raymond V. Mechanism of action of hypothalamic hormones in the anterior pituitary gland and specific modulation of their activity by sex steroids and thyroid hormones. Rec Prog Horm Res 1978, 35:25-93

18.       Caron MG, Beaulieu M, Raymond V, Gagné B, Drouin J, Lefkowitz RJ, Labrie F. Dopaminergic receptors in the anterior pituitary gland. Correlation of H -dihydroergocryptine binding with the dopaminergic control of prolactin release. J Biol Chem 1978, 253:2244-2253

17.       Drouin J, Lavoie M, Labrie F. Effect of gonadal steroids on the LH and FSH response to 8 Br-cyclic AMP in anterior pituitary cells in culture. Endocrinology 1978, 102:358-361

16.       Meyers C, Arimura A, Gordin A, Fernandez-Durango R, Coy DH, Schally AV, Drouin J, Ferland L, Beaulieu M, Labrie F. Somatostatin analogs which inhibit glucagon and growth hormone more than insulin release. Biochem Biophys Res Commun 1977, 74:630-636

15.       Lagacé L, Ferland L, Drouin J, Asselin J, Labrie F, Azadian-Boulanger G, Raynaud JP. Activité inhibitrice importante du R 5020 sur la sécrétion de LH et FSH chez le rat. Revue française d'endocrinologie, Métabolisme et Nutrition, 1977, 18:411-422

14.       Labrie F, Ferland L, Lagacé L, Drouin J, Asselin J, Azadian-Boulanger G, Raynaud JP. High inhibitory activity of R5020, a pure progestin, at the hypothalamic-adenohypophyseal level on gonadotropin secretion. Fertil Steril 1977, 28:1104-1112

13.       De Léan A, Ferland L, Drouin J, Kelly PA, Labrie F. Modulation of pituitary TRH receptor levels by estrogens and thyroid hormones. Endocrinology 1977, 100:1496-1504

12.       Labrie F, De Léan A, Drouin J. Interactions des oestrogènes et des hormones thyroidiennes dans le contrôle de la réponse de la TSH à la TRH. INSERM, colloque de synthèse 1976, série Action Thématique, Rapport No. 7:Actions thématiques 22 et 35, Neuroendocrinologie, 1977, 331-342

11.       Labrie F, Drouin J, Lagacé L, Ferland L. Mechanism of control of LH and FSH secretion by LH-RH and gonadal steroids. Progr Rep Biol 1976, 2:36-41

10.       Drouin J, Lagacé L, Labrie F. Estradiol-induced increase of the LH responsiveness to LH-RH in anterior pituitary cells in culture. Endocrinology 1976, 99:1477-1481

9.         Drouin J, Beaulieu M, Borgeat P, Ferland L, Labrie F. Contrôle de la sécrétion des hormones adénohypophysaires. Revue de Médecine 1976, 32:1717-1727

8.         Drouin J, Labrie F. Selective effect of androgens on LH and FSH release in anterior pituitary cells in culture. Endocrinology 1976, 98:1528-1534

7.         Labrie F, Ferland L, Borgeat P, Drouin J, Beaulieu M, Schally AV. Mechanism of control of LH and FSH secretion. In "Proceedings of the First Int. Congr. on Human Reproduction" (A Campos de Paz and AV Schally, eds), Excerpta Medica Congress Series, 1976, 370:127-133

6.         Drouin J, De Léan A, Rainville D, Lachance R, Labrie F. Characteristics of the interaction between TRH and somatostatin for thyrotropin and prolactin release. Endocrinology 1976, 98:514-521

5.         Drouin J, Ferland L, Bernard J, Labrie F. Site of the in vivo stimulatory effect of prostaglandins on LH release. Prostaglandins 1976, 2:367-376

4.         Drouin J, Labrie F. Specificity of the stimulatory effect of prostaglandins on hormone release in anterior pituitary cells in culture. Prostaglandins 1976, 355-366

3.         Labrie F, Pelletier G, Drouin J, Bélanger A, Ferland L, Lemay A, Lemaire S, Beaulieu M. Mechanism of action of hypothalamic hormones in anterior pituitary gland. In "Basic applications and clinical uses of hypothalamic hormones in anterior pituitary gland", Excerpta Medica, Int. Congr. Series, 1975, 374:l00-110

2.         Bélanger A, Labrie F, Borgeat P, Savary M, Côté J, Drouin J, Schally AV, Coy DH, Coy EJ, Immer H, Sestanj K, Nelson V, Gotz M. Inhibition of growth hormone and thyrotropin release by growth hormone-release-inhibiting hormone. J Mol Cell Endocrinol 1974, 1:329-339

1.         Borgeat P, Labrie F, Drouin J, Bélanger A, Immer H, Sestanj K, Nelson V, Gotz M, Schally AV, Coy DH, Coy EJ. Inhbition of adenosine 3', 5'-monophosphate accumulation in anterior pituitary gland in vitro by growth hormone release-inhibiting hormone. Biochem Biophys Res Commun 1974, 56:1052-1059

Book chapters

51.       Drouin J. Pituitary Development. In: The Pituitary 3rd Edition. Melmed S (Ed), Elsevier-Academic Press, Publishers; 2010, pp 3-19

50.       Drouin J, Bilodeau S, Roussel-Gervais A. Stem cells, differentiation and cell cycle control in pituitary. In Pituitary Today II: New Molecular, Physiological and Clinical Aspects. Arzt E, Bronstein M, Guitelman M (Vol Eds), Grossman AB (Ser Ed). Basel Karger. Frontiers of Hormone Research, 2010, vol 38, pp15-24

49.       Drouin J. Molecular mechanisms of pituitary differentiation and regulation: implications for hormone deficiencies and for hormone resistance syndromes. In: Pituitary today. S Karger AG, Basel. Frontiers of Hormone Research, 2006, vol 35, pp74-87

48.       Drouin J, Pulichino AM, Vallette-Kasic S. Pituitary developmental abnormalities: molecular basis of clinical phenotype. In: Molecular pathogenesis and therapy of pituitary disease. BioScientifica Ltd Publisher, Ho K, Chihara K (Eds); Bristol UK. HypoCCS Series, 2006, vol. 9 p. 1-10

47.       Sadikot AF, Luk KC, van den Munckhof P, Rymar VV, Leung K, Gandhi R, Drouin J. Pitx3 is necessary for survival of midbrain dopaminergic neuron subsets relevant to Parkinson’s disease. 8th Triennial Meeting of Int’l Basal Ganglia Society. Bolam JP, Ingham CA, Magill PJ (Eds). Springer Science. The Basal Ganglia VIII (Advances in Behavioral Biology), 2005, vol 56, pp. 265-274

46.       Nudi M, Batsché É, Drouin J. Ontogeny of the pituitary corticotroph system. In: The ACTH axis: Pathogenesis, Diagnosis and Treatment. Gaillard RC, Melmed S (Eds), New York, Kluwer Academic Publishers, 2003, 352 pp

45.       Drouin J. Pitx (Ptx) transcription factors. In: Wiley Encyclopedia of Molecular Medicine, 5 vol. Set, John Wiley & Sons, Inc. New York USA 2002, 2504-2506

All rights reserved: IRCM 2011_110 avenue des Pins Ouest - Montréal (Québec) H2W 1R7 – Canada