The research conducted in this unit focuses on the study of signal transduction mechanisms in the immune and hematopoietic systems. Over the last decade, this group has identified and characterized numerous intracellular molecules that play a crucial role in normal cellular physiology. A number of these molecules are directly or indirectly implicated in the pathogenesis of leukemias, lymphomas and other malignancies. They have also been linked to the development of certain immunodeficiencies. These proteins are potential targets in therapeutic immunosuppression for the treatment of autoimmune diseases and graft rejection. Novel molecular, cellular and biochemical approaches are used by the research team to study these molecules.

   Duration: 2 min 41 s
Discovery of a control mechanism against cancer and infections (in French only)