The aim of the research program of the Biomedical Engineering Research Unit is to determine the impact of aortic stenosis and the systemic arterial pressure on the coronary flow circulation and the left ventricular function. The approaches investigated are based on theoretical models of flow circulation (fluid mechanics) in the heart and arteries, in vitro studies, and experimental studies in the sheep model correlated with quantitative hemodynamic observations in patients. These studies are performed in collaboration with Drs. Lyes Kadem, Concordia University and Philippe Pibarot, Hôpital Laval, Université Laval.