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EDUCATION
DIPLÔME D’ÉTUDES COLLÉGIALES 1985-1987
Marianapolis College, Montréal, Qc, Canada
BACHELOR OF SCIENCE (HON.) 1987-1990
Department of Microbiology and Immunology, McGill University, Montréal, Qc, Can-ada
PH. D. 1991–1996
Department of Human and Molecular Genetics, Baylor College of Medicine, Hous-ton, TX, USA
APPOINTMENTS
PRE-DOCTORAL FELLOW 1991-1996
Laboratory of Dr. Hugo Bellen, Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, TX, USA
POSTDOCTORAL FELLOW 1996-2000
Laboratory of Dr. Thomas Jessell, Center for Neurobiology and Behavior, Columbia University, NY, NY, USA
ASSOCIATE RESEARCH SCIENTIST 2000-2004
Laboratory of Dr. Thomas Jessell, Center for Neurobiology and Behavior, Columbia University, NY, NY, USA
UNIT DIRECTOR 2005-PRESENT
Neural Circuit Development Laboratory, Institut de recherches cliniques de Montréal, Montréal, Qc, Canada
CHERCHEUR ADJOINT 2005-PRESENT
Faculté de médecine, Université de Montréal, Montréal, Qc, Canada
ASSOCIATE MEMBER 2005-PRESENT
Division of Experimental Medicine, McGill University, Montréal, Qc, Canada
ADJUNCT PROFESSOR 2005-PRESENT
Department of Anatomy and Cell Biology, McGill University, Montréal, Qc, Canada
MEMBER 2007-PRESENT
Centre of Excellence in Neuromics of Université de Montréal, Montréal, Qc, Canada
INTERIM AXIS DIRECTOR 2009
Neurobiology and Development Axis
Institut de recherches cliniques de Montréal, Montréal, Qc, Canada
ADJUNCT PROFESSOR 2009-PRESENT
Department of Biology, McGill University, Montréal, Qc, Canada.
ASSISTANT RESEARCH PROFESSOR IRCM 2009-PRESENT
Institut de recherches cliniques de Montréal, Montréal, Qc, Canada
PROFESSIONAL ACTIVITIES
COUNCIL MEMBER 2008-PRESENT
International Society for Developmental Neuroscience
CIHR PEER REVIEW COMMITTEE MEMBER 2007-PRESENT
Developmental Biology
THESIS
Mutations in neuromusculin and benchwarmer affect early nervous system devel-opment and neuronal survival. (Ph. D.)
OPERATING GRANTS
EJLB FOUNDATION 3 YEARS 2005-2008
Scholar Research Programme, “Development of myotopy in the motor system” ($350 000 total)
CIHR 1 YEAR 2005-2006
Canadian Institutes of Health Research, Institute of Genetics Bridging Grant, “Eph receptor function in neural circuit formation” ($100 000 total)
CIHR 5 YEARS 2005-2010
Canadian Institutes of Health Research, Operating Grant, “Eph receptor function in neural circuit formation” ($115 500 p.a.)
SICKKIDS FOUNDATION 2 YEARS 2008-2010
New Investigators Grant, “Using the Spinal Cord as a Model to Study Neuronal Mi-gration Disorders” ($65 000 p.a.)
MDA (US) 3 YEARS 2008-2011
Research Grant, “Motor neuron survival factors in development” ($121 650 p.a.)
CIHR 3 YEARS 2009-2012
Canadian Institutes of Health Research, Operating Grant, “Netrin function in spinal motor axon guidance” ($124 500 p.a.)
PUBLICATIONS
REFEREED JOURNAL ARTICLES
1. A. Kania, P.-L. Han, Y.-T. Kim and H. Bellen. Neuromusculin, a Drosophila gene ex-pressed in peripheral neuronal precursors and muscles, encodes a cell adhesion molecule. (1993). Neuron 11:673-687
2. A. Kania and H. Bellen. Mutations in neuromusculin, a gene encoding a cell ad-hesion molecule, cause nervous system defects. (1995). Roux’s Arch. Dev. Biol. 204:259-270.
3. A. Kania, A. Salzberg, M. Bhat, D. D’Evelyn, Y. -C. He, I. Kiss and H. Bellen. P-element mutations affecting embryonic peripheral nervous system development in D. melanogaster. (1995). Genetics 139: 1663-1678.
4. J. T. Littleton, L. Upton and A. Kania. Immunocytochemical analysis of axonal out-growth in synaptotagmin mutations. (1995). J. Neurochem. 65:32-40.
5. W. Shawlot, M. Wakamiya, K.M. Kwan, A. Kania, T.M. Jessell and R. R. Behringer. Lim1 is required in both primitive streak-derived tissues and visceral endoderm for head formation in the mouse. (1999). Development 126: 4925-4932.
6. T. E. Tsang, W. Shawlot, S. J. Kinder, A. Kobayashi, K. M. Kwan, K. Schughart, A. Kania, T. M. Jessell, R. R. Behringer, and P. P. Tam. Lim1 activity is required for in-termediate mesoderm differentiation in the mouse embryo. (2000). Dev Biol 223:77-90.
7. A. Kania, R. Johnson, and T. M. Jessell. Coordinate roles for LIM homeobox genes in directing the dorsoventral trajectory of motor axons in the vertebrate limb. (2000). Cell 102:161-73.
8. A. Kania and T. M. Jessell. Topographic Motor Projections into the Limb Imposed by LIM Homeodomain Protein Regulation of Ephrin-A:EphA Interactions. (2003). Neu-ron 38:581-596.
9. A. Kobayashi, W. Shawlot, A. Kania, and R. R. Behringer . Requirement of Lim1 for female reproductive tract development. (2004). Development 131:539-549.
10. Y.-Q. Ding, J. Yin, A. Kania, H.-M. Xu, T. M. Jessell, R. Johnson, and Z.-F. Chen. Lmx1b controls the differentiation of laminae I-II cells and subsequent projection of cutaneous afferents in the spinal cord. (2004). Development 131:3693-3703.
11. J. P. Thaler, S. J. Koo, A. Kania, K. Lettieri. S. Andrews, C. Cox, T. M. Jessell, and S. L. Pfaff. A postmitotic role for Isl-class LIM homeodomain proteins in the assign-ment of visceral spinal motor neuron identity. (2004). Neuron 41:337-350.
12. B. Dermaut, K. K. Norga, A. Kania, P. Verstreken, H. Pan, Y. Zhou, P. Callaerts, and H. J. Bellen. Aberrant lysosomal carbohydrate storage accompanies endocytic de-fects and neurodegeneration in Drosophila benchwarmer. (2005). J Cell Biol. 170:127-39.
13. A. B. Huber, A. Kania, T. S. Tran, C. Gu, N. de Marco Garcia, I. Lieberam, D. John-son, T. M. Jessell, D. D. Ginty and A. Kolodkin. Distinct roles for secreted Sema-phorin signaling in spinal motor axon guidance. (2005). Neuron 48:949-64.
14. D. Krawchuk and A. Kania. Identification of Lmx1b targets in the developing limb mesenchyme. (2008). Dev. Dyn. 237:1183-1192.
15. A. Freitas, N. Stifani, A. Liakhovitskaia, A. Medvinski, A. Kania, and S. Stefani. Regulation of Spinal Motor Neuron Identity by the Runx1 Transcription Factor. (2008). PNAS 105:6451-6456.
16. V. Luria, D. Krawchuk, T. M. Jessell, E. Laufer, and A. Kania. Specification of motor axon trajectory by ephrin-B:EphB signaling: symmetrical control of axonal patterning in the developing limb. (2008). Neuron 60:1039-1053.
17. M. L. Suster, A. Kania, M. Liao, K. Asakawa, F. Charron, K. Kawakami and P. Drapeau. A novel conserved evx1 enhancer links spinal interneuron morphology and cis-regulation from fish to mammals. (2009). Dev. Biol. 325:422-433.
18. T.-J. Kao, E. Palmesino, and A. Kania. Src family kinases are required for limb tra-jectory selection by spinal motor axons. (2009). J. Neuroscience 29:5690 –5700.
19. X. W. Gu and A. Kania. Examining the combinatorial model of motor neuron survival by expression profiling of trophic factors and their receptors in the embryonic Gallus gallus. (2010). Dev. Dyn. In press.
MANUSCRIPTS SUBMITTED AND IN PREPARATION
20. E. Palmesino, D. Rousso, T.-J. Kao, A. Klar, E. Laufer, O. Uemura, H. Okamoto B. Novitch and A. Kania. Foxp1 and Lhx1 coordinate motor neuron migration with axon trajectory choice by gating Reelin signalling. (2009). PLoS Biology. In review.
21. D. Krawchuk, S. Poliak, F. Charron, J.F. Cloutier and A. Kania. Netrin coordi-nates spinal motor neuron myotopy through attractive and repulsive receptors. (2010). In preparation.
22. X. W. Gu and A. Kania. Identification of Lmx1b targets in the developing limb mus-cles. (2010). In preparation.
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