|
FORMATION ET DIPLÔMES
DIPLÔME D’ÉTUDES COLLÉGIALES 1985-1987
Marianapolis College, Montréal, Qc, Canada
B.SC. (HON.) 1987-1990
Déparetment de Microbiologie et d'immunology, Université McGill, Montréal, Qc, Canada
PH. D. 1991–1996
Deparement of Human and Molecular Genetics, Baylor College of Medicine, Houston, TX, USA
STAGIAIRE PRÉDOCTORAL 1991-1996
Laboratory of Dr. Hugo Bellen, Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, TX, USA
STAGIAIRE POSTDOCTORAL 1996-2000
Laboratory of Dr. Thomas Jessell, Center for Neurobiology and Behavior, Columbia University, NY, NY, USA
CHERCHEUR ASSOCIÉ 2000-2004
Laboratory of Dr. Thomas Jessell, Center for Neurobiology and Behavior, Columbia University, NY, NY, USA
DIRECTEUR 2005-PRÉSENT
Laboratoire de développement des circuits neuronaux, Institut de recherches cliniques de Montréal, Montréal, Qc, Canada
CHERCHEUR ADJOINT 2005-PRÉSENT
Faculté de médecine, Université de Montréal, Montréal, Qc, Canada
ADJUNCT PROFESSOR 2005-PRÉSENT
Division de médecine expérimentale, Université McGill, Montréal, Qc, Canada
ADJUNCT PROFESSOR 2005-PRÉSENT
Déparetment d'anatomie et de biologie cellulaire, Université McGill, Montréal, Qc, Canada
MEMBRE 2007-PRÉSENT
Centre d'excellence en Neuromque de l'Université de Montréal, Montréal, Qc, Canada
DIRECTEUR PAR INTERIM 2009
Axe Neurobiologie et Développement
Institut de recherches cliniques de Montréal, Montréal, Qc, Canada
ADJUNCT PROFESSOR 2009-PRÉSENT
Département de biologie, Université McGill, Montréal, Qc, Canada.
PROFESSEUR DE RECHERCHES ADJOINT IRCM 2009-PRÉSENT
Institut de recherches cliniques de Montréal, Montréal, Qc, Canada
ACTIVITÉS PROFESSIONNELLES
MEMBRE DU CONSEIL 2008-PRÉSENT
International Society for Developmental Neuroscience
MEMBRE DU COMITÉ D'EXAMEN DES PAIRS - IRSC 2007-PREÉENT
Biologie dévelopmentale
THÈSE DE DOCTORAT
Mutations in neuromusculin and benchwarmer affect early nervous system devel-opment and neuronal survival. (Ph. D.)
SUBVENTIONS DE FONCTIONNEMENT
FONDATION EJLB 3 ANS 2005-2008
Scholar Research Programme, “Development of myotopy in the motor system” ($350 000 total)
IRSC 1 AN (TRANSITOIRE) 2005-2006
Institut de recherches en santé du Canada, Institut de génétique, “Eph receptor function in neural circuit formation” ($100 000 total)
IRSC 5 ANS 2005-2010
Institut de recherches en santé du Canada, “Eph receptor function in neural circuit formation” ($115 500 p.a.)
SICKKIDS FOUNDATION 2 ANS 2008-2010
Bourse de nouveau chercheur, “Using the Spinal Cord as a Model to Study Neuronal Mi-gration Disorders” ($65 000 p.a.)
MDA (US) 3 ANS 2008-2011
Research Grant, “Motor neuron survival factors in development” ($121 650 p.a.)
IRSC 3 ANS 2009-2012
Institut de recherches en santé du Canada, “Netrin function in spinal motor axon guidance” ($124 500 p.a.)
PUBLICATIONS
REVUES DOTÉES DE COMITÉS DE PAIRS
1. A. Kania, P.-L. Han, Y.-T. Kim and H. Bellen. Neuromusculin, a Drosophila gene ex-pressed in peripheral neuronal precursors and muscles, encodes a cell adhesion molecule. (1993). Neuron 11:673-687
2. A. Kania and H. Bellen. Mutations in neuromusculin, a gene encoding a cell ad-hesion molecule, cause nervous system defects. (1995). Roux’s Arch. Dev. Biol. 204:259-270.
3. A. Kania, A. Salzberg, M. Bhat, D. D’Evelyn, Y. -C. He, I. Kiss and H. Bellen. P-element mutations affecting embryonic peripheral nervous system development in D. melanogaster. (1995). Genetics 139: 1663-1678.
4. J. T. Littleton, L. Upton and A. Kania. Immunocytochemical analysis of axonal out-growth in synaptotagmin mutations. (1995). J. Neurochem. 65:32-40.
5. W. Shawlot, M. Wakamiya, K.M. Kwan, A. Kania, T.M. Jessell and R. R. Behringer. Lim1 is required in both primitive streak-derived tissues and visceral endoderm for head formation in the mouse. (1999). Development 126: 4925-4932.
6. T. E. Tsang, W. Shawlot, S. J. Kinder, A. Kobayashi, K. M. Kwan, K. Schughart, A. Kania, T. M. Jessell, R. R. Behringer, and P. P. Tam. Lim1 activity is required for in-termediate mesoderm differentiation in the mouse embryo. (2000). Dev Biol 223:77-90.
7. A. Kania, R. Johnson, and T. M. Jessell. Coordinate roles for LIM homeobox genes in directing the dorsoventral trajectory of motor axons in the vertebrate limb. (2000). Cell 102:161-73.
8. A. Kania and T. M. Jessell. Topographic Motor Projections into the Limb Imposed by LIM Homeodomain Protein Regulation of Ephrin-A:EphA Interactions. (2003). Neu-ron 38:581-596.
9. A. Kobayashi, W. Shawlot, A. Kania, and R. R. Behringer . Requirement of Lim1 for female reproductive tract development. (2004). Development 131:539-549.
10. Y.-Q. Ding, J. Yin, A. Kania, H.-M. Xu, T. M. Jessell, R. Johnson, and Z.-F. Chen. Lmx1b controls the differentiation of laminae I-II cells and subsequent projection of cutaneous afferents in the spinal cord. (2004). Development 131:3693-3703.
11. J. P. Thaler, S. J. Koo, A. Kania, K. Lettieri. S. Andrews, C. Cox, T. M. Jessell, and S. L. Pfaff. A postmitotic role for Isl-class LIM homeodomain proteins in the assign-ment of visceral spinal motor neuron identity. (2004). Neuron 41:337-350.
12. B. Dermaut, K. K. Norga, A. Kania, P. Verstreken, H. Pan, Y. Zhou, P. Callaerts, and H. J. Bellen. Aberrant lysosomal carbohydrate storage accompanies endocytic de-fects and neurodegeneration in Drosophila benchwarmer. (2005). J Cell Biol. 170:127-39.
13. A. B. Huber, A. Kania, T. S. Tran, C. Gu, N. de Marco Garcia, I. Lieberam, D. John-son, T. M. Jessell, D. D. Ginty and A. Kolodkin. Distinct roles for secreted Sema-phorin signaling in spinal motor axon guidance. (2005). Neuron 48:949-64.
14. D. Krawchuk and A. Kania. Identification of Lmx1b targets in the developing limb mesenchyme. (2008). Dev. Dyn. 237:1183-1192.
15. A. Freitas, N. Stifani, A. Liakhovitskaia, A. Medvinski, A. Kania, and S. Stefani. Regulation of Spinal Motor Neuron Identity by the Runx1 Transcription Factor. (2008). PNAS 105:6451-6456.
16. V. Luria, D. Krawchuk, T. M. Jessell, E. Laufer, and A. Kania. Specification of motor axon trajectory by ephrin-B:EphB signaling: symmetrical control of axonal patterning in the developing limb. (2008). Neuron 60:1039-1053.
17. M. L. Suster, A. Kania, M. Liao, K. Asakawa, F. Charron, K. Kawakami and P. Drapeau. A novel conserved evx1 enhancer links spinal interneuron morphology and cis-regulation from fish to mammals. (2009). Dev. Biol. 325:422-433.
18. T.-J. Kao, E. Palmesino, and A. Kania. Src family kinases are required for limb tra-jectory selection by spinal motor axons. (2009). J. Neuroscience 29:5690 –5700.
19. X. W. Gu and A. Kania. Examining the combinatorial model of motor neuron survival by expression profiling of trophic factors and their receptors in the embryonic Gallus gallus. (2010). Dev. Dyn. In press.
MANUSCRITS SOUMIS ET EN PRÉPARATION
20. E. Palmesino, D. Rousso, T.-J. Kao, A. Klar, E. Laufer, O. Uemura, H. Okamoto B. Novitch and A. Kania. Foxp1 and Lhx1 coordinate motor neuron migration with axon trajectory choice by gating Reelin signalling. (2009). PLoS Biology. In review.
21. D. Krawchuk, S. Poliak, F. Charron, J.F. Cloutier and A. Kania. Netrin coordi-nates spinal motor neuron myotopy through attractive and repulsive receptors. (2010). In preparation.
22. X. W. Gu and A. Kania. Identification of Lmx1b targets in the developing limb mus-cles. (2010). In preparation.
|  | |