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The IRCM > Research > Research divisions > Neurobiologie et développement > Développement et plasticité des synapses
Home > Synapse Development and Plasticity
Home > Synapse Development and Plasticity
Research unit director
Synapse Development and Plasticity
Dr. Hideto Takahashi’s laboratory is interested in the molecular and cellular mechanisms that control the development and plasticity of chemical synapses in the brain. Central synapses are neuronal cell-cell adhesion sites essential for information processing in the brain by exciting and inhibiting neuronal activity as excitatory and inhibitory synapses, respectively. A balanced development of excitatory and inhibitory synapses is important for normal brain functions, and an imbalance in this development is supposed to be the etiology of neurodevelopmental and neuropsychiatric disorders such as epilepsy, autism and schizophrenia. In addition, central synapses morphologically and functionally change in response to synaptic activity and experience. The plastic changes in synapses are important for learning and memory.

Using cellular and molecular biology, biochemistry and genetic approach, we aim to characterize “synaptic organizing complexes”, which are trans-synaptic adhesion protein complexes that can directly trigger synapse formation. We also aim to uncover modulatory regulation of synaptic organizing complexes in order to demonstrate new molecular basis on synaptic plasticity. These studies will help to develop the new diagnostic and therapeutic strategies for neuropsychiatric disorders and cognitive dysfunction in disease brains.  

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