Research associate

Summary of responsibilities

The candidate has the responsibility to conduct experiments towards specific research projects using the above-mentioned methods and project-specific reagents independently, but with guidance from the Director of the IRCM Hematopoiesis and Cancer Research Unit. The candidate has the responsibility to work according to the best practices and guidelines set forth by the IRCM for laboratory work, including reporting, writing abstracts for meeting, preparing posters for conferences, regular presentation of results, writing publication drafts and potentially required revisions, preparing the required protocol for the use of human tissue or blood, and the required biosafety protocols. 

Main tasks

The candidate will work under the supervision of the director of the IRCM research unit “Hematopoiesis and Cancer”, on a specific project involving a subgroup of ribonucleic acids that have no coding potential and are classified as “long-noncoding RNAs (or lncRNAs)”. The candidate must have experience with these molecules their functional analysis and must have expertise in the biochemistry, molecular biology, and genomics of these types of RNAs. In addition, the candidate must have expertise in the technology of genomic analyses that allow the identification of molecular targets of lncRNAs, specifically in ChIRP-MS (Comprehensive identification of RNA-binding proteins by mass spectrometry), ChIRP-seq (Comprehensive identification of RNA-binding proteins by sequencing), RNA-immuno-precipitation and related techniques such as cell cycle analyses, small molecular fluorescence in situ hybridization (smFISH) and must have expertise in the analysis of genomic data. Ideally the candidate has already worked with the lncRNAs MALAT1 and ELDR, which are molecules regulating the proliferation and malignant transformation of immune cells. The candidate must be able to work under sterile condition, i.e. with laminar flow hoods and must have expertise in manipulating human and murine cell lines as well as primary cells in tissue culture. The candidate must have experience in the construction and use of lentiviral vectors used to transfect human or murine cells. The candidate must have expertise in operate equipment such as centrifuges, PCR machines, multiplex readers, high speed flow cytometers, microscopes and with support mass spectrometer and be versed in computer software for data analysis typical for a molecular biology laboratory.

Required qualifications

Ph.D. level degree or equivalent in biomedical research with a specialization in molecular biology of ribonucleic acids without coding potential (lncRNA). 

Terms and conditions of employment

  • Full-time temporary position (35h/week).
  • With benefits to be discussed
  • Contribution to the Régime de retraite des employés du gouvernement et des organismes publics (RREGOP) 
  • Life and health insurance plans 
  • Employee assistance program

We prioritize Canadian citizens

How to apply

Send your resume immediately, specifying Competition – Research associate, “Hematopoiesis and Cancer” research unit to mariana.correro@ircm.qc.ca.

We thank all applicants for their interest, however, only those selected for an interview will be contacted.


 
 

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