Research associate position (staff scientist) in the Côté laboratory

You are looking for a Research position in a thriving and warm environment where you can collaborate with some of the best scientists across the world? This offer might be for you.

The position
Research Associate position: A research associate position (staff scientist) is available to contribute to a project aiming to define the proximity interactomes of RAS oncogenes as well as the ones of lesser studied RAS proteins. The project involves BioID proteomics, protein biochemistry, cell biology and cancer models (including CRISPR, mice and patient samples). This project of international stature is being conducted in collaboration with experts across Québec and Ontario as part of an emerging initiative to lead new treatments for RAS-driven cancers. Under limited direction, the research associate will plan and manage all aspects of the research project, from design to publication. The research associate will also supervise and train junior scientists in the laboratory in addition

Our work
Summary: Research in the Côté laboratory is focused on understanding the molecular and cellular mechanisms underpinning the dynamic regulation of the cytoskeleton, and how this contributes to either developmental processes such as muscle development or cell migration/invasion during breast cancer metastasis. We use state-of-the-art approaches in proteomics, genomics, and cell biology, and also use mouse models to address our questions. We aim to exploit the knowledge we generate to develop novel therapeutic opportunities for cancer or muscle diseases. 

To read some of our recent work on RAS proteins in cytoskeletal dynamics, on breast cancer metastasis, or in developmental biology, click on the following links:

“Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms” Bagci et al., Nature Cell Biology (2020)
“Targeting Axl favors an antitumorigenic microenvironment that enhances immunotherapy responses by decreasing Hif-1α levels” Goyette et al., PNAS (2021)
“AXL confers cell migration and invasion by hijacking a PEAK1-regulated focal adhesion protein network” Abu-Thuraia et al., Nature Communications (2020)
“Spatiotemporal regulation of the GPCR activity of BAI3 by C1qL4 and Stabilin-2 controls myoblast fusion” Hamoud et al., Nature Communications (2018)

Main Tasks and Responsibilities:
•    Research design and planning the project
•    Conducting experiments and fine-tuning the methodologies
•    Data analysis, interpretation, and presentation in lab meetings
•    Managing productive interactions with the collaborators
•    Preparing figures for grants and manuscripts and contribute to writing
•    Training and supervision of junior scientists
•    Fostering a supportive, collaborative, and productive laboratory environment
•    A Ph.D. in a relevant field (biochemistry, molecular biology, etc.) and post-doctoral training in academia or industry (2-5 years). 
•    Expertise in biochemistry, cell culture, microscopy, ideally with the use of mouse models. 
•    Proteomics, programming and machine learning skills are an asset. 
•    Demonstrated ability to conduct research published in reputed journals. 
•    We are looking for an applicant with exceptional organization and time management skills and capable of working independently as part of team where professional communication and interpersonal skills are essential. 
•    Strong written and oral communication skills. 
•    Capacity to evaluate and resolve complex issues (troubleshooting of experiments, developing new methodologies, finesse of collaborative interactions, grant deadlines, etc.).
•    The ideal candidate will demonstrate high work and research ethics and pay strong attention to details.

Working Conditions
This is a full-time position with a salary range between 59 000$ to 78 000$ according to previous work experience. Full benefits are included (group insurance, pension plan).

Why the IRCM if for you!
The IRCM is a leading independent biomedical research institute with a mission to understand biology and diseases through scientific discoveries. Over 30 teams are dedicated to contributing research advances in cancer, cardiometabolic health, genetic and neurological disorders, and immunity, inflammation, and infectious diseases. The IRCM, with a rich history of over 55 years, is an internationally recognized institution with numerous contributions to biomedical research and with a track record of training many prominent scientists employed in all spheres of health and research. By joining us, you have an opportunity to shape your career in a unique non-profit institution dedicated completely to research and training.

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