Disease Modeling
and Genome Editing

Yacine Kherdjemil, PhD



Team: Li Lian, MSc, Research Assistant

Mouse models of human diseases are essential for advancing biomedical research.

At the IRCM Disease Modeling and Genome Editing platform, we offer specialized expertise and state-of-the-art technologies to generate mouse models. Our methods include cutting-edge techniques such as CRISPR/Cas9, i-GONAD electroporation and pronuclear microinjection.

We provide personalized and expert support tailored to the needs of your research projects, from initial experimental design to the delivery of your mouse model.

Our services are available to IRCM researchers, as well as external academic and corporate researchers.


CRISPR/Cas9 mediated genome editing

>    Generation of Knock-in Mice
•    Point mutation alleles 
•    Epitope tag alleles
•    Conditional alleles

>    Generation of Knock-out Mice
•    Interval deletion alleles
•    Insertion/deletion (indel) alleles

Generation of transgenic mice via pronuclear microinjection

Cryopreservation and Embryology

•    Sperm Cryopreservation
•    Sperm and Embryo Cryorecovery
•    Embryo Transfer / Mouse Strain Rederivation
•    In Vitro Fertilization

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Disease modeling
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