New insights into the role of Notch signaling in T and B cell immunity

Ivan Maillard, MD, PhD
Chair
Laurence Joseph Dinner in
Leukemia Research

Head
Division of Hematologic Malignancies
Department of Medicine
Memorial Sloan Kettering Cancer Center

This conference is hosted by Nathalie Labrecque, PhD. This conference is part of the 2025-2026 IRCM conference calendar.

About this conference
Dr. Maillard will discuss emerging functions of Notch signaling in T and B cell immunity, with a focus on the following areas of investigation: 1) Role of stroma-driven Notch signals in graft-versus-host disease, the major immune complication of allogeneic hematopoietic cell transplantation; 2) New functions of Notch signaling in T follicular helper cell responses to immunization; 3) Positional regulation of mouse and human B cells by Notch signaling.

About Ivan Maillard
Ivan Maillard, MD, PhD is the Laurence Joseph Dinner Chair in Leukemia Research and Head of the Division of Hematologic Malignancies at Memorial Sloan Kettering Cancer Center (MSK) in New York, NY. Dr. Maillard earned his MD at the University of Lausanne, Switzerland, and his MD-PhD from the University of Lausanne and the Swiss Academy of Medical Sciences. He completed a residency in Internal Medicine at the University of Lausanne Medical Center, followed by a fellowship in Hematology-Oncology and a post-doctoral fellowship at the University of Pennsylvania Perelman School of Medicine. He then started his independent career at the University of Michigan where he stayed for 10 years and rose through the ranks before joining Penn in 2018 as a Professor of Medicine and Vice-Chief for Research in the Division of Hematology/Oncology. Dr. Maillard is dedicated to training and mentoring a new generation of scientists and physician-scientists working on blood and cancer research, as well as hematopoietic cell transplantation. In 2024, Dr. Maillard was recruited to MSK where he leads a large academic Division of Hematologic Malignancies with a focus on clinical care, research and innovation, training and career development, and service to the community.
 
Dr. Maillard’s research focuses on the role of Notch signaling in hematopoiesis as well as in T and B cell development, differentiation and function. Through more than 15 years of research in the field, his laboratory discovered essential functions for Notch receptors and ligands in graft-versus-host disease with a high fundamental and translational impact. His work identified specialized stromal niches that represent the critical sources of Notch ligands in secondary lymphoid organs, sparking a new interest in the biology of lymphoid tissue fibroblastic reticular cells in immune and hematologic disorders

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