Mary Baylies

Nuclei, Position, Activity: Decoding Cell Size Regulation in Muscle Development and Disease

Mary Baylies, PhD
Professor of Developmental Biology
Sloan Kettering Institute
New York, NY, USA

This conference is hosted by PhD student Sarah Nahlé (laboratory of Jean-François Côté, PhD).This conference is part of the 2022-2023 IRCM conference calendar.

In person: 
IRCM Auditorium
110, avenue des Pins O, H2W 1R7 Montreal

Online:
Zoom Link : https://zoom.us/j/95269762104
ID : 952 6976 2104
Code : 476372

IRCM conferences are set to occur under a hybrid format. However, please note that last-minute changes to online-only lectures may occur due to unforeseen circumstances. We invite you to visit this webpage again a few days before attending.

About this conference
Skeletal muscle cells are one of the few cells in the body that are multinucleated: a human muscle cell has hundreds of nuclei and is amongst the largest cells of the body. All muscle nuclei (myonuclei) contribute to muscle cell size and function, yet recent evidence indicate that there are differences amongst the myonuclei within each muscle cell. This seminar will focus on when and how these differences arise.  Moreover, how different conditions of muscle wasting, including nemaline myopathy, cancer cachexia, and aging, impact the position, morphology, and activity of myonuclei will be discussed.

About Mary Baylies
Dr. Mary Baylies is a Full Member in the Developmental Biology Program in Sloan Kettering Institute at the Memorial Sloan Kettering Cancer Center. Her laboratory investigates muscle specification, differentiation, homeostasis and function during normal development and in disease contexts. The work from her group has provided new insights to muscle identity through interactions between signal transduction pathways, transcription factors and chromatin regulators; muscle size through identification of mechanisms involved in muscle fusion and growth; and muscle function through study of genes and mechanisms responsible for myonuclear movement and positioning. Her laboratory continues to investigate how muscle cells are formed, how individual muscles achieve particular sizes and shapes, and how muscle subcellular architecture changes during differentiation, muscle function, and in diseases including rhabdomyosarcoma, nemaline myopathy, centronuclear myopathies, and cancer cachexia. 

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