Patient-derived organoids to understand epithelial-immune crosstalk

Dr. Jeroen Roose, PhD
Professor & Vice Chair
Department of Anatomy

Co-Founder
UCSF Bakar ImmunoX initiative

Founder
UCSF Organoid Core
University of California, San Francisco
 

This conference is hosted by André Veillette, PhD, Director of the Molecular Oncology Research Unit, and Jean-François Côté, PhD, Director of the Cytoskeletal Organization and Cell Migration Research Unit.

About this conference
We are cellular systems biologists and our research is organized around three intersecting themes: (i) Tumor cell fitness, with emphasis on lineage infidelity, cell identity crises, metabolic adaptation, and cancer–host cell interactions, particularly in metastasis; (ii) Stem cell fitness, focusing on lineage potential, niche-derived cues, and stem cell–immune cell crosstalk; (iii) T cell fitness, studying the functional capabilities of naïve-, effector-, and regulatory- T cells relevant to autoimmunity and immune oncology.

In the presentation at IRCM, I will cover how we investigate (a) the fitness and lineage potential of intestinal stem and progenitor cells, receiving immune cell clues. In part (b) I will discuss how we developed new platforms to understand T cell fitness and exhaustion as these immune cells see cancer cells. In both lines of research, we utilize organoids and single cell omics, which I will cover in the introduction.
 

About Jeroen Roose
I received my PhD training in The Netherlands studying Wnt signaling and cancer in the laboratory of Dr. Hans Clevers, followed by postdoctoral training at UCSF in the laboratory of Dr. Arthur Weiss, where I investigated Ras signaling in lymphocytes. These experiences shaped my career-long interest in cellular fitness across tissues and disease contexts. I established my independent laboratory at UCSF in 2007 and am currently a tenured Professor and Vice Chair of Anatomy.

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