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Nov 21, 2022
From 11:30 AM to 12:30 PM

Location QCCanada
IRCM Conference

Carmen Birchmeier

Carmen Birchmeier

An oscillatory network controls muscle stem cell fate

Carmen Birchmeier, PhD
Max Delbrück Center for Molecular Medicine
C. Birchmeier Lab
Berlin, Germany

This conference is hosted by Jean-François Côté, PhD. This conference is part of the 2022-2023 IRCM conference calendar.

In person: 
IRCM Auditorium
110, avenue des Pins O, H2W 1R7 Montreal
Wearing a mask is mandatory at all times

Zoom Link :
ID : 952 6976 2104
Code : 476372

IRCM conferences are set to occur under a hybrid format. However, please note that last-minute changes to online-only lectures may occur due to unforeseen circumstances. We invite you to visit this webpage again a few days before attending.

About this conference: 
Skeletal muscle has a remarkable regenerative capacity due to resident stem cells that can form new muscle fibers. Stem cells of the skeletal muscle represent a small cell population in the postnatal muscle that were originally defined as satellite cells by their anatomical location between the basal lamina and plasma membrane of the myofiber. These stem cells derive from myogenic progenitor cells and are marked by Pax7. They proliferate during the postnatal period and generate differentiating cells for muscle growth. In the adult, muscle stem cells are quiescent but become activated and proliferate upon muscle injury. The proliferative muscle stem cells can either self-renew or differentiate to generate new muscle tissue. The balance between self-renewal and differentiation of the stem cells is tightly controlled, ensuring the maintenance of a cellular pool needed for muscle growth and repair. Notch signaling controls this choice between self-renewal and differentiation. In recent years, we have found that activated muscle stem cells express a network of genes in an oscillatory manner. This network of oscillating genes encompasses Dll1, Hes1 and MyoD, and the oscillations depend on Notch signaling. We demonstrated that these oscillations are not only an odd phenomenon, but functionally important for the regulation of proliferation and differentiation. I will discuss our work on oscillatory gene expression in muscle stem cells, the regulatory mechanisms underlying the dynamic expression, and the function of the oscillations in muscle development and regeneration.

For more details see also:
Zhang et al. 2021, Nature Communications
Lahmann et al. 2019, Genes & Development

About Carmen Birchmeier:
Dr. Carmen Birchmeier is a Professor at the Neuroscience Research Center of the Charité – Berlin University of Medicine and Head of the 'Signal Transduction/Developmental Biology' Research Group at the Max Delbrück Center for Molecular Medicine (Berlin, Germany), where she is recognized for her strength in community building. Her research program focuses on functional analysis of genes important in development and stem cells, concentrating on muscle, the nervous system and endocrine organs. The work of Dr. Birchmeier has been published in high-calibre journals such as Cell Stem Cell, Nature Communications, Genes & Development, etc.


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