IRCM Activities
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Sep 19, 2022
From 11:30 AM to 12:30 PM

Location QCCanada

Judith N. Mandl

Judith N. Mandl

A squash and a squeeze: T cell migration challenges in navigating tissues

Judith N. Mandl, PhD
Associate Professor
Department of Physiology
Faculty of Medicine and Health Sciences
McGill University

This conference is organized by Javier Di Noia. It is part of the 2022-2023 IRCM conference calendar.

In person: 
IRCM Auditorium
110, avenue des Pins O, H2W 1R7 Montreal
Wearing a mask is mandatory at all times

Zoom Link :
ID : 952 6976 2104
Code : 476372

IRCM conferences are set to occur under a hybrid format. However, please note that last-minute changes to online-only lectures may occur due to unforeseen circumstances. We invite you to visit this webpage again a few days before attending.

About the conference:
T cells, important effector cells of the immune system, are highly dynamic cells in both space and time. Their commute between and within tissues in the body is essential to effective immune responses. In my lab, we study how immune cell migratory processes orchestrate T cell responses, and the challenges that T cells face when they migrate within distinct tissue environments. We are particularly interested in explaining immune cell population heterogeneity in behaviour and function, and use a variety of methods to perturb immune cell migration in particular to learn from unexpected outcomes. Overall, our work on understanding the spatial ecology of T cells in diverse microanatomies aims to provide new tools to prevent T cells survival in specific tissues where they are causing disease (autoimmunity, allergies, transplantation), or to increase their mobility in challenging, crowded microenvironments such as tumours.

About Judith N. Mandl:
Dr. Judith N. Mandl is an associate professor in the Department of Physiology of McGill University and a member of the McGill University Research Centre on Complex Traits. Her lab focuses on the role of T-cell migration, interactions and heterogeneity in the orchestration of effective T-cell immune responses. She is a Canada Research Chair in Immune Cell Dynamics, and was recently the recipient of the 2021 New Investigator Award from the Canadian Society for Immunology. Her work, supported by grants from CIHR, NSERC, and the International Human Frontier Science Program, has led to several major scientific breakthroughs published in top journals including Nature Immunology, Immunity, Nature Medicine and others.

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