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		ResearchOur research
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PlatformsOur platforms
Animal Facilities and Animal Health
Bioinformatics
Molecular Biology and Functional Genomics
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Home
Research
Researchers

IRCM Researchers
Creating new

knowledgeExploring new avenues to develop tomorrow’s medical knowledge through an approach that integrates basic and clinical research
Our research units are led by principal investigators who collaborate in a spirit of collegiality and with the vision of bridging the gap between research and patients. They train the next generation of scientists and are independent and creative minds who work tirelessly to improve health.
 
Marie

TrudelDirector, Molecular Genetics and Development Research Unit
Current research
Molecular Genetics and DevelopmentOne of the main objectives of this research unit is to study molecular mechanisms that control genetic regulation and expression in transgenic mice. Scientists on this team have produced a sickle cell transgenic mouse model through a mutation in the adult beta-globin gene to study the pathophysiology of the disease and to develop effective gene therapy approaches. They are also analyzing transcriptional factors involved in the most primitive cells of hematopoietic differentiation.
Furthermore, they are characterizing the PKD1 gene responsible for polycystic kidney disease and studying the signal transduction pathway using a transgenic mouse model induced with the protooncogène c-myc.
Available positions  Clinical studies 


	
			Team
		

			Almira KURBEGOVIC Chercheuse associée Research Associate Almira.Kurbegovic@ircm.qc.ca 
Tabasum ABDUL-RASUL Adjointe administrative Administrative Assistant Tabasum.Abdul-Rasul@ircm.qc.ca 
William FOLEY Stagiaire avec crédits Intern With Credits William.Foley@ircm.qc.ca 

		




	
			Affiliations
		

			Director, Molecular Genetics and Development Research Unit, IRCM
Full IRCM Research Professor
Full Research Professor, Department of Medicine (accreditation in molecular biology, and in biochemistry and molecular medicine), Université de Montréal
Adjunct Professor, Department of Medicine (Division of Experimental Medicine), McGill University


		




	
			Degrees and experience
		

			PhD in biochemistry and genetics, Université Pierre et Marie Curie, Paris, France (1982)
Postdoctoral fellowship in genetics and mutagenesis, Imperial Cancer Research Fund, London, United Kingdom (1982-1985)
Postdoctoral fellowship in genetics and development, Columbia University, New York, USA (1985-1989)


		




	
			Publications
		

			Kurbegovic A, Trudel M, The master regulators Myc and p53 cellular signaling and functions in polycystic kidney disease. - Cellular Signalling 2020 Jul
Shmukler BE, Rivera A, Bhargava P, Nishimura K, Hsu A, Kim EH, Trudel M, Rust MB, Hubner CA, Brugnara C, Alper SL, Corrigendum to "Combined genetic disruption of K-Cl cotransporters and Gardos channel KCNN4 rescues erythrocyte dehydration in the SAD mouse model of sickle cell disease" [Blood Cells Mol. Dis. (2019) start page-end page not yet assigned] doi.org/10.1016/j.bcmd.2019.102346. - Blood Cells, Molecules & Diseases 2020 Mar
Shmukler BE, Rivera A, Bhargava P, Nishimura K, Hsu A, Kim EH, Trudel M, Rust MB, Hubner CA, Brugnara C, Alper SL, Combined genetic disruption of K-Cl cotransporters and Gardos channel KCNN4 rescues erythrocyte dehydration in the SAD mouse model of sickle cell disease. - Blood Cells, Molecules & Diseases 2019 Nov
Parrot C, Kurbegovic A, Yao G, Couillard M, Côté O, Trudel M, c-Myc is a regulator of the PKD1 gene and PC1-induced pathogenesis. - Human Molecular Genetics 2019 Mar 1
Billot K, Coquil C, Villiers B, Josselin-Foll B, Desban N, Delehouzé C, Oumata N, Le Meur Y, Boletta A, Weimbs T, Grosch M, Witzgall R, Saunier S, Fischer E, Pontoglio M, Fautrel A, Mrug M, Wallace D, Tran PV, Trudel M, Bukanov N, Ibraghimov-Beskrovnaya O, Meijer L, Casein kinase 1ε and 1α as novel players in polycystic kidney disease and mechanistic targets for (R)-roscovitine and (S)-CR8. - American Journal Of Physiology. Renal Physiology 2018 Jul 1
Trudel M, Sedzro JC, Approaches for Analysis of Erythroid Cell Parameters and Hemoglobinopathies in Mouse Models. - Methods In Molecular Biology (Clifton, N.J.) 2018
Ren J, Ding X, Trudel M, Greer JJ, MacLean JE, Cardiorespiratory pathogenesis of sickle cell disease in a mouse model. - Scientific Reports 2017 Aug 17
Ilboudo Y, Bartolucci P, Rivera A, Sedzro JC, Beaudoin M, Trudel M, Alper SL, Brugnara C, Galactéros F, Lettre G, Genome-wide association study of erythrocyte density in sickle cell disease patients. - Blood Cells, Molecules & Diseases 2017 Jun
Gamberi C, Hipfner DR, Trudel M, Lubell WD, Bicaudal C mutation causes myc and TOR pathway up-regulation and polycystic kidney disease-like phenotypes in Drosophila. - PLoS Genetics 2017 Apr
Hajarnis S, Lakhia R, Yheskel M, Williams D, Sorourian M, Liu X, Aboudehen K, Zhang S, Kersjes K, Galasso R, Li J, Kaimal V, Lockton S, Davis S, Flaten A, Johnson JA, Holland WL, Kusminski CM, Scherer PE, Harris PC, Trudel M, Wallace DP, Igarashi P, Lee EC, Androsavich JR, Patel V, microRNA-17 family promotes polycystic kidney disease progression through modulation of mitochondrial metabolism. - Nature Communications 2017 Feb 16
Kurbegovic A, Trudel M, Acute kidney injury induces hallmarks of polycystic kidney disease. - American Journal Of Physiology. Renal Physiology 2016 Oct 1
Trudel M, Yao Q, Qian F, The Role of G-Protein-Coupled Receptor Proteolysis Site Cleavage of Polycystin-1 in Renal Physiology and Polycystic Kidney Disease. - Cells 2016 Jan 21
Trudel M, Li X, c-Myc Signalling in the Genetic Mechanism of Polycystic Kidney Disease -  2015 Nov
Zhou X, Fan LX, Peters DJ, Trudel M, Bradner JE, Li X, Therapeutic targeting of BET bromodomain protein, Brd4, delays cyst growth in ADPKD. - Human Molecular Genetics 2015 Jul 15
Kurbegovic A, Kim H, Xu H, Yu S, Cruanès J, Maser RL, Boletta A, Trudel M, Qian F, Novel functional complexity of polycystin-1 by GPS cleavage in vivo: role in polycystic kidney disease. - Molecular And Cellular Biology 2014 Sep
Kosan C, Rashkovan M, Ross J, Schaffer AM, Saba I, Lemsaddek W, Trudel M, Möröy T, The transcription factor Miz-1 is required for embryonic and stress-induced erythropoiesis but dispensable for adult erythropoiesis. - American Journal Of Blood Research 2014
Vassen L, Beauchemin H, Lemsaddek W, Krongold J, Trudel M, Möröy T, Growth factor independence 1b (gfi1b) is important for the maturation of erythroid cells and the regulation of embryonic globin expression. - PloS One 2014
Kurbegovic A, Trudel M, Progressive development of polycystic kidney disease in the mouse model expressing Pkd1 extracellular domain. - Human Molecular Genetics 2013 Jun 15
Shmukler BE, Hsu A, Alves J, Trudel M, Rust MB, Hubner CA, Rivera A, Alper SL, N-ethylmaleimide activates a Cl(-)-independent component of K(+) flux in mouse erythrocytes. - Blood Cells, Molecules & Diseases 2013 Jun
Pang CJ, Lemsaddek W, Alhashem YN, Bondzi C, Redmond LC, Ah-Son N, Dumur CI, Archer KJ, Haar JL, Lloyd JA, Trudel M, Kruppel-like factor 1 (KLF1), KLF2, and Myc control a regulatory network essential for embryonic erythropoiesis. - Molecular And Cellular Biology 2012 Jul
Stoyanova E, Cloutier G, Felfly H, Lemsaddek W, Ah-Son N, Trudel M, Evidence for a novel mechanism independent of myocardial iron in β-thalassemia cardiac pathogenesis. - PloS One 2012
Stoyanova E, Trudel M, Felfly H, Lemsaddek W, Garcia D, Cloutier G, Vascular endothelial dysfunction in β-thalassemia occurs despite increased eNOS expression and preserved vascular smooth muscle cell reactivity to NO. - PloS One 2012
Boosalis MS, Castaneda SA, Trudel M, Mabaera R, White GL, Lowrey CH, Emery DW, Mpollo MS, Shen L, Wargin WA, Bohacek R, Faller DV, Perrine SP, Novel therapeutic candidates, identified by molecular modeling, induce γ-globin gene expression in vivo. - Blood Cells, Molecules & Diseases 2011 Aug 15
Kurbegovic A, Côté O, Couillard M, Ward CJ, Harris PC, Trudel M, Pkd1 transgenic mice: adult model of polycystic kidney disease with extrarenal and renal phenotypes. - Human Molecular Genetics 2010 Apr 1
Felfly H, Trudel M, Successful correction of murine sickle cell disease with reduced stem cell requirements reinforced by fractionated marrow infusions. - British Journal Of Haematology 2010 Feb
Vandorpe DH, Xu C, Shmukler BE, Otterbein LE, Trudel M, Sachs F, Gottlieb PA, Brugnara C, Alper SL, Hypoxia activates a Ca2+-permeable cation conductance sensitive to carbon monoxide and to GsMTx-4 in human and mouse sickle erythrocytes. - PloS One 2010 Jan 15
Ross J, Bottardi S, Bourgoin V, Wollenschlaeger A, Drobetsky E, Trudel M, Milot E, Differential requirement of a distal regulatory region for pre-initiation complex formation at globin gene promoters. - Nucleic Acids Research 2009 Sep
Bottardi S, Ross J, Bourgoin V, Fotouhi-Ardakani N, Affar el B, Trudel M, Milot E, Ikaros and GATA-1 combinatorial effect is required for silencing of human gamma-globin genes. - Molecular And Cellular Biology 2009 Mar
Beauchemin H, Trudel M, Evidence for a bigenic chromatin subdomain in regulation of the fetal-to-adult hemoglobin switch. - Molecular And Cellular Biology 2009 Mar
Couillard M, Trudel M, C-myc as a modulator of renal stem/progenitor cell population. - Developmental Dynamics : An Official Publication Of The American Association Of Anatomists 2009 Feb
Szuber N, Buss JL, Soe-Lin S, Felfly H, Trudel M, Ponka P, Alternative treatment paradigm for thalassemia using iron chelators. - Experimental Hematology 2008 Jul
Cadieux C, Harada R, Paquet M, Côté O, Trudel M, Nepveu A, Bouchard M, Polycystic kidneys caused by sustained expression of Cux1 isoform p75. - The Journal Of Biological Chemistry 2008 May 16
Felfly H, Trudel M, Long-term correction of beta-thalassemia with minimal cellular requirement and transplantation modalities. - Molecular Therapy : The Journal Of The American Society Of Gene Therapy 2007 Sep
Rust MB, Alper SL, Rudhard Y, Shmukler BE, Vicente R, Brugnara C, Trudel M, Jentsch TJ, Hübner CA, Disruption of erythroid K-Cl cotransporters alters erythrocyte volume and partially rescues erythrocyte dehydration in SAD mice. - The Journal Of Clinical Investigation 2007 Jun
Stoyanova E, Trudel M, Felfly H, Garcia D, Cloutier G, Characterization of circulatory disorders in beta-thalassemic mice by noninvasive ultrasound biomicroscopy. - Physiological Genomics 2007 Mar 14
Thivierge C, Kurbegovic A, Couillard M, Guillaume R, Coté O, Trudel M, Overexpression of PKD1 causes polycystic kidney disease. - Molecular And Cellular Biology 2006 Feb
Mpollo MS, Beaudoin M, Berg PE, Beauchemin H, D'Agati V, Trudel M, BP1 is a negative modulator of definitive erythropoiesis. - Nucleic Acids Research 2006
Beauchemin H, Blouin MJ, Trudel M, Differential regulatory and compensatory responses in hematopoiesis/erythropoiesis in alpha- and beta-globin hemizygous mice. - The Journal Of Biological Chemistry 2004 May 7
Couillard M, Guillaume R, Tanji N, D'Agati V, Trudel M, c-myc-induced apoptosis in polycystic kidney disease is independent of FasL/Fas interaction. - Cancer Research 2002 Apr 15


		


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IRCM Researchers

Creating new knowledge

Marie Trudel

Current research

Molecular Genetics and Development

Important Discoveries

Tools

Join the group Research

Available positions

Graduate research projects Polycystic Kidney Disease

Ongoing clinical studies

Research Partners

Join the research group

Life in the laboratory

Discoveries, events and more

Be part of the solution

Research

Platforms

Student life

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The Institure

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The Clinic

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Contact us

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Newsroom

Creating new
knowledge

Marie
Trudel

Join the
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Join the
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