Noncoding RNA biology

Summary of responsibilities

The RNA and Noncoding Mechanisms of Disease Research Unit (www.sauvageaulab.org) is seeking to recruit a candidate wishing to pursue graduate studies (M.Sc. or PhD) in the field of noncoding RNAs and genome regulation. The group is located at the Montreal Clinical Research Institute (IRCM) and candidates can be affiliated to either University of Montréal or McGill University.

The Sauvageau lab combines genetically engineered animal models and human cellular systems with functional genomics and CRISPR-based genome editing techniques to perturb lncRNA functions and characterize their role at a cellular and physiological level. We also aim to understand the molecular grammar that underlies lncRNA function and uncover novel noncoding RNA-based mechanisms. For this, we use a combination of biochemistry, high-throughput and computational approaches to identify RNA-interacting macromolecules and RNA domains that mediate their function. Our goal is to better understand the impact that lncRNAs and noncoding regions have on development and reveal novel RNA-based mechanisms that could lead to the generation of novel diagnostics and therapies. The team is multi-disciplinary and part of a network of labs investigating RNA in genome regulation.

Required qualifications

Strong academic record and pertinent experience in biochemistry, molecular and cellular biology, and/or in bioinformatics (an asset).

How to apply

Please send your resume, grades and a cover letter explaining why you want to join the lab. Also include the names and contact information for two referees to the Research Unit Director martin.sauvageau@ircm.qc.ca.

For more information

Martin Sauvageau Research Unit webpage
www.umontreal.ca
www.mcgill.ca
www.sauvageaulab.org

 

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