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Olivier Pourquié, PhD

Oct 03, 2022
From 11:30 AM to 12:30 PM

Montréal


IRCM Conference

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IRCM Challenge

From Oct 08 to Oct 23 2022


Athletic Challenge

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Damien Contandriopoulos

Oct 13, 2022
From 12 PM to 1 PM


Conference

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Sekar Kathiresan, MD

Oct 17, 2022
From 11:30 AM to 12:30 PM

Montréal


Conference

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Carl Wu, PhD

Oct 24, 2022
From 11:30 AM to 12:30 PM

Montréal


Conference

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Geneviève Almouzni, PhD

Oct 31, 2022
From 11:30 AM to 12:30 PM

Montréal


Conference

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Rashmi Kothary, PhD

Nov 07, 2022
From 11:30 AM to 12:30 PM

Montréal


Conference

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Kathryn E. Wellen, PhD

Nov 14, 2022
From 11:30 AM to 12:30 PM

Montréal


Conference

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Carmen Birchmeier-Kohler, PhD

Nov 21, 2022
From 11:30 AM to 12:30 PM

Montréal


Conference

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Oscar Marín, PhD

Nov 28, 2022
From 11:30 AM to 12:30 PM

Montréal


Conference

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Annual Dinner

Dec 01, 2022
Montréal


Dinner

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Julie Segre, PhD

Dec 12, 2022
From 11:30 AM to 12:30 PM

Montréal


Conference

Évènements passés

Miranda Hunter

Special Conference
Miranda Hunter

Spatial regulation of melanoma invasion

Miranda Hunter, PhD
Postdoctoral fellow
Memorial Sloan Kettering Cancer Center

Special Conference: This speaker is a candidate for the Research Unit Director position available at the IRCM.


In person: 
IRCM Auditorium
110, avenue des Pins O, H2W 1R7 Montreal
Wearing a mask is mandatory at all times

Online:
Zoom Link : https://zoom.us/j/94078486709
ID : 940 7848 6709
Code : 785826

This conference is set to occur under a hybrid format. However, please note that last-minute changes to online-only lecture may occur due to unforeseen circumstances. We invite you to visit this webpage again a few days before attending.


Abstract:
I work at the interface of cell biology, cancer biology, and mechanobiology to define the factors that influence how tumors interact with neighbouring tissues as they grow and invade. To this end, I will discuss my work applying spatial and single-cell transcriptomics and quantitative microscopy to a zebrafish model of melanoma. This approach revealed that cells spanning the tumor border are reprogrammed to support tumor invasion, and uncovered a novel role for cilia in invasion. This spatially-restricted reprogramming is mediated by the chromatin modifier HMGB2, which is highly upregulated at the tumor border. I will describe new work uncovering a novel mechanosensitive role for HMGB2 in invasive tumor cells, modulating chromatin architecture, gene expression, and cell state in response to mechanical force. Finally, I will discuss my plans for future work focused on the influence of the mechanical microenvironment on tumor cell biology and tumor progression.

 

 

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