lncRNA Biology and RNA Therapeutics

Summary of responsibilities

The RNA and Noncoding Mechanisms of Disease Research Unit (www.sauvageaulab.org), headed by Martin Sauvageau, is seeking to recruit a highly motivated and dynamic postdoctoral fellow to study critical questions on the biological functions and molecular interactions of lncRNAs associated to diseases. The group is located at the Montreal Clinical Research Institute (IRCM) and candidates can be affiliated to either University of Montréal or McGill University.

The Sauvageau lab combines genetically engineered animal models and human cellular systems with functional genomics and CRISPR-based genome editing techniques to perturb lncRNA functions and characterize their role at a cellular and physiological level. We also aim to understand the molecular grammar that underlies lncRNA function and uncover novel noncoding RNA-based mechanisms. For this, we use a combination of biochemistry, high-throughput and computational approaches to identify RNA-interacting macromolecules and RNA domains that mediate their function. Our goal is to better understand the impact that lncRNAs and noncoding regions have on development and reveal novel RNA-based mechanisms that could lead to the generation of novel diagnostics and therapies. The team is multi-disciplinary and part of a network of labs investigating RNA in genome regulation.

Availability

Immediately, until the position is filled. 

Required qualifications

Successful candidates will have completed (or be on the verge of completing) doctoral studies in biology, biochemistry, genetics, genomics, bioinformatics or a related discipline. Candidates should have significant experience with standard molecular/cellular biology and biochemical approaches, with a particular emphasis on RNA-related experimentation. Moreover, individuals with experience in genomics/transcriptomics approaches, RNA-protein interactions or bioinformatics/statistical analyses methodologies will be given strong consideration. A strong publication record and demonstrated ability to perform impactful research as part of a multidisciplinary, broadly collaborative team are required.

How to apply

Please send a cover letter, a CV and the names and contact information of three referees by email to the Research Unit Director martin.sauvageau@ircm.qc.ca.

For more information

Martin Sauvageau Research Unit webpage
www.umontreal.ca
www.mcgill.ca
www.sauvageaulab.org

 

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