Clonal and cellular dynamics of the antibody response

Gabriel D. Victora, PhD
Laurie and Peter Grauer Assistant Professor
The Rockefeller University
New York, NY, USA

This conference is organized by Hua Gu. It is part of the 2021-2022 IRCM conference calendar.

In person: 
IRCM Auditorium
110, avenue des Pins O, H2W 1R7 Montreal
Wearing a mask is mandatory at all times

Online:
Zoom Link : https://zoom.us/j/95269762104
ID : 952 6976 2104
Code : 476372

IRCM conferences are set to occur under a hybrid format. However, please note that last-minute changes to online-only lectures may occur due to unforeseen circumstances. We invite you to visit this webpage again a few days before attending.

About the conference:
The average affinity of specific antibodies increases dramatically over the course of an immune response. This increase is the result of a Darwinian process in which B lymphocytes undergo iterative cycles of random hypermutation of their immunoglobulin genes, followed by selective proliferation of clones bearing affinity-enhancing mutations. This evolutionary process takes place in highly dynamic microanatomical structures known as germinal centers, which arise within secondary lymphoid organs upon infection or immunization. Our work combines intravital multiphoton microscopy with mouse genetics to study how the dynamics of B and T lymphocytes within germinal centers shapes the evolution of the high-affinity antibodies that are crucial to protection from infectious disease. 

About Gabriel D. Victoria:
Dr. Gabriel Victora is an Assistant Professor at The Rockefeller University (New York, USA), where he runs the Laboratory of Lymphocyte Dynamics. His research work focuses mainly on the regulation of B lymphocyte activation and differentiation, as well as on the process of antibody affinity maturation. His discoveries have been published in several of the best peer-reviewed journals, including Science, Nature, Cell and Immunity. Since the start of his career, Dr. Victora has received numerous prestigious awards and nominations: he is a Pew-Stewart Scholar (2019), a Burroughs-Wellcome Investigator in the Pathogenesis of Infectious Disease (2018), a MacArthur Fellow (2017) and a Searle Scholar (2017). He is also the recipient of the NIH Director’s Pioneer Award (2018).

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