IRCM Activities
and Events

Filter

Events to come

thumbnail

Olivier Pourquié, PhD

Oct 03, 2022
From 11:30 AM to 12:30 PM

Montréal


IRCM Conference

thumbnail

IRCM Challenge

From Oct 08 to Oct 23 2022


Athletic Challenge

thumbnail

Damien Contandriopoulos

Oct 13, 2022
From 12 PM to 1 PM


Conference

thumbnail

Sekar Kathiresan, MD

Oct 17, 2022
From 11:30 AM to 12:30 PM

Montréal


Conference

thumbnail

Carl Wu, PhD

Oct 24, 2022
From 11:30 AM to 12:30 PM

Montréal


Conference

thumbnail

Geneviève Almouzni, PhD

Oct 31, 2022
From 11:30 AM to 12:30 PM

Montréal


Conference

thumbnail

Rashmi Kothary, PhD

Nov 07, 2022
From 11:30 AM to 12:30 PM

Montréal


Conference

thumbnail

Kathryn E. Wellen, PhD

Nov 14, 2022
From 11:30 AM to 12:30 PM

Montréal


Conference

thumbnail

Carmen Birchmeier-Kohler, PhD

Nov 21, 2022
From 11:30 AM to 12:30 PM

Montréal


Conference

thumbnail

Oscar Marín, PhD

Nov 28, 2022
From 11:30 AM to 12:30 PM

Montréal


Conference

thumbnail

Annual Dinner

Dec 01, 2022
Montréal


Dinner

thumbnail

Julie Segre, PhD

Dec 12, 2022
From 11:30 AM to 12:30 PM

Montréal


Conference

Évènements passés

Stephen Methot, PhD

Special Conference
Stephen Methot, PhD

Dynamic control of chromatin accessibility during development and in differentiated tissues

Stephen Methot, PhD

Postdoctoral fellow
Friedrich Miescher Institute for Biomedical Research
Basel, Switzerland

Special Conference: This speaker is a candidate for the Research Unit Director position available at the IRCM.


In person :
IRCM auditorium
110, avenue des Pins O, H2W 1R7 Montreal
Wearing a mask is mandatory at all times

Zoom
URL : https://zoom.us/j/94078486709
ID : 940 7848 6709
Code : 785826


Abstract :
To orchestrate gene expression programs during development, multicellular organisms physically separate regions of the genome into open euchromatin and closed heterochromatin. This genome-wide organization is highly dependent on the cellular differentiation state and/or tissue type. Understanding how tissue-specific genome organization impacts cellular identity as well as how dynamic chromatin modifications and accessibility drive robust animal development remain essential unresolved questions in biology. Using the model organism C. elegans, I have begun to gain mechanistic insight into these problems at the cell, tissue, and organismal levels. Specifically, I will present my work studying the tissue-specific regulation and function of the heterochromatic histone post-translational modification, histone 3 lysine 9 methylation, focusing on its role in muscle cells. Furthermore, I will present my recent efforts to use and establish C. elegans as a model system for studying the molecular mechanisms that dictate dynamic changes to chromatin during development by taking advantage of a rhythmic and highly dynamic transcription program required for C. elegans cuticle shedding and renewal (molting). Ultimately, my goals are to unravel fundamental principles that underly tissue specific chromatin accessibility and dynamics with the potential to identify novel therapeutic targets for disrupting or modifying chromatin states in disease.

Newsletter

Discoveries,
events and more

Subscribe

IRCM Foundation

Be part of the
solution

Support health research